Air pollution linked to cardiovascular risk indices in healthy yo...(ses in high-sensitivity C-reactive prote...),Health

Date:8/15/2007

ses in high-sensitivity C-reactive protein (hs-CRP) (an indicator of risk for a cardiovascular event), 8-hydroxy-2-deoxyguanosine (8-OHdG) (a marker of oxidative stress), fibrinogen (a coagulation factor), plasminogen activator fibrinogen inhibitor-1 (PAI-1) (a marker of inflammation) and decreases in heart rate variability (HRV) (a predictor of increased cardiovascular risk) were associated with increases in particulate matter, sulfate, nitrate, and ozone when they analyzed pollutants singly, and that increases in 8-OHdG, fibrinogen, and PAI-1 and decreases HRV were correlated to increased ozone and sulfate levels over three day averages in multi-pollutant models.

The precise biological mechanisms involved were not able to be determined with this studys design. Further studies with more detailed measurements of cardiovascular endpoints over time are still needed to elucidate the time sequence of pollution effects on cardiovascular endpoints in humans, wrote Dr. Chang-Chuan Chan.

Many questions remain to be answered, wrote Joel Kaufman, M.D., M.P. H., in the accompanying editorial, [But] these questions should by no means slow the important efforts to reduce exposures and benefit global public health.

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Contact: Suzy Martin smartin@thoracic.org 212-315-8631 American Thoracic Society Source:Eurekalert

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