Navigation Links
Air pollution linked to cardiovascular risk indices in healthy young adults
Date:8/15/2007

Researchers in Taiwan have demonstrated for the first time that urban air pollution simultaneously affects key indicators of cardiovascular risk in young adults: inflammation, oxidative stress, coagulation and autonomic dysfunction.

The study, which appeared in the second issue for August of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society, investigated the effect of common urban air pollutants on biological markers for inflammation, oxidative stress, coagulation and autonomic dysfunction in 76 healthy Taiwanese college students.

The researchers collected blood samples and performed electrocardiograms on each subject approximately every 30 days for the months of April, May and June in either 2004 or 2005. They then correlated the sample dates and time with monitoring data from a fixed-site air monitoring station on the students campus. The concentrations of common urban air pollutants were averaged over 24, 48 and 72 hours.

They found significant increases in all indices of cardiovascular risk were associated with increased exposure to common pollutants. This study provides evidence that urban air pollution is associated with systemic inflammation/oxidative stress, impairment of the fibrinogenic system, activation of blood coagulation and alterations in the autonomic nervous system in young, healthy humans, wrote the studys lead author Chang-Chuan Chan, Sc.D., of National Taiwan Universitys College of Public Health.

Most pollution literature has shown affects in elderly people, and although there have been experiments in young subjects, epidemiological research has not found such significant effects in young people as with these students in Taiwan, said Benoit Nemery, M.D., Ph.D., professor in the division of pneumonology at the Catholic University of Leuvin in Belgium, who was not involved in the research.

Specifically, the investigators found that increases in high-sensitivity C-reactive protein (hs-CRP) (an indicator of risk for a cardiovascular event), 8-hydroxy-2-deoxyguanosine (8-OHdG) (a marker of oxidative stress), fibrinogen (a coagulation factor), plasminogen activator fibrinogen inhibitor-1 (PAI-1) (a marker of inflammation) and decreases in heart rate variability (HRV) (a predictor of increased cardiovascular risk) were associated with increases in particulate matter, sulfate, nitrate, and ozone when they analyzed pollutants singly, and that increases in 8-OHdG, fibrinogen, and PAI-1 and decreases HRV were correlated to increased ozone and sulfate levels over three day averages in multi-pollutant models.

The precise biological mechanisms involved were not able to be determined with this studys design. Further studies with more detailed measurements of cardiovascular endpoints over time are still needed to elucidate the time sequence of pollution effects on cardiovascular endpoints in humans, wrote Dr. Chang-Chuan Chan.

Many questions remain to be answered, wrote Joel Kaufman, M.D., M.P. H., in the accompanying editorial, [But] these questions should by no means slow the important efforts to reduce exposures and benefit global public health.


'/>"/>

Contact: Suzy Martin
smartin@thoracic.org
212-315-8631
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Air pollution affects the heart
2. Pollution could be a risk
3. Pollution- hazardous for diabetics
4. Air Pollution Found To Accelerate Heart Disease
5. Air pollution may raise risk of lung cancer
6. Air pollution hits heart patients during exercise
7. Air Pollution and Heart Attacks
8. Air pollution combined with greater medical needs
9. Traffic pollution linked to severe asthma attacks
10. Air Pollution Tied to Stroke Risk
11. Air Pollution said To Increase Risk of Cardiovascular Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... Worth, TX (PRWEB) , ... October 13, 2017 ... ... financial planning agency serving communities in the greater Dallas, Miami, and Raleigh regions, ... young boy fighting to overcome a rare and deadly chromosome abnormality. , After ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... ... established the certification process to promote standards of excellence for the field of ... scheduled for March 22 – 25, 2018 in Orlando, Florida at the Omni ...
(Date:10/13/2017)... ... 2017 , ... Many families have long-term insurance that covers care for a ... waiver for care if the client has a cognitive impairment diagnosis. , “What ... is often waived, so the benefits from their insurance start immediately,” said Mechell Vieira, ...
(Date:10/13/2017)... ... ... Talented host, actor Rob Lowe, is introducing a segment ... of "Success Files," which is an award-winning educational program broadcasted on PBS Member ... with passion and integrity. , Sciatica occurs when the sciatic nerve in the ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... treating sleep apnea using cutting-edge Oventus O2Vent technology. As many as ... disorder characterized by frequent cessation in breathing. Oral appliances can offer significant relief ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... Oct. 2, 2017  AllianceRx Walgreens Prime, the combined ... Walgreens and pharmacy benefit manager Prime Therapeutics LLC (Prime), ... which included the unveiling of new signage at its ... well as at a few other company-owned facilities across ... to patients, some of whom will begin to see ...
(Date:9/27/2017)... 2017  Commended for their devotion to personalized service, SMP ... number one in the South Florida Business Journal,s 50 Fastest-Growing ... yearly list, the national specialty pharmacy has found its niche.  ... will soon be honored by SFBJ as the 2017 Power ... Set to receive his award in October, Bardisa said of ...
(Date:9/22/2017)... -- As the latest Obamacare repeal effort moves is debated, ... and Lindsey Graham (R-SC) medical device market ... is in an odd place.  The industry wants repeal ... on medical device sales passed along with the Affordable ... visits and hospital customers with the funding to invest ...
Breaking Medicine Technology: