Researchers in Taiwan have demonstrated for the first time that urban air pollution simultaneously affects key indicators of cardiovascular risk in young adults: inflammation, oxidative stress, coagulation and autonomic dysfunction.
The study, which appeared in the second issue for August of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society, investigated the effect of common urban air pollutants on biological markers for inflammation, oxidative stress, coagulation and autonomic dysfunction in 76 healthy Taiwanese college students.
The researchers collected blood samples and performed electrocardiograms on each subject approximately every 30 days for the months of April, May and June in either 2004 or 2005. They then correlated the sample dates and time with monitoring data from a fixed-site air monitoring station on the students campus. The concentrations of common urban air pollutants were averaged over 24, 48 and 72 hours.
They found significant increases in all indices of cardiovascular risk were associated with increased exposure to common pollutants. This study provides evidence that urban air pollution is associated with systemic inflammation/oxidative stress, impairment of the fibrinogenic system, activation of blood coagulation and alterations in the autonomic nervous system in young, healthy humans, wrote the studys lead author Chang-Chuan Chan, Sc.D., of National Taiwan Universitys College of Public Health.
Most pollution literature has shown affects in elderly people, and although there have been experiments in young subjects, epidemiological research has not found such significant effects in young people as with these students in Taiwan, said Benoit Nemery, M.D., Ph.D., professor in the division of pneumonology at the Catholic University of Leuvin in Belgium, who was not involved in the research.
Specifically, the investigators found that increa
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American Thoracic Society