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Air pollution alters immune function, worsens asthma symptoms
Date:10/5/2010

), a longitudinal study led by principal investigator Dr. Ira Tager, professor of epidemiology at UC Berkeley's School of Public Health, and co-principal investigator S. Katharine Hammond, UC Berkeley professor and chair of environmental health sciences. The researchers also recruited 30 children from Fresno who did not have asthma.

"I'm not aware of any other studies that have looked at how chemicals can alter cells so early in the regulatory process, and then connected that effect to clinical symptoms," said Tager. "There are people who still question the direct link between air pollution and human health, but these findings make the health impact of pollutants harder to deny."

Fresno was chosen because it is located in California's Central Valley, where trapped hot air mixes with high traffic and heavy agriculture to create some of the highest levels of air pollution in the country. It is also a region known for its high incidence of asthma: Nearly one in three children there have the condition, earning Fresno the nickname, "The Asthma Capitol of California."

The researchers compared the participants from Fresno with 80 children, half with asthma and half without, in the relatively low-pollution city of Palo Alto, Calif. The children were matched by age, gender and asthma status, among other variables. The children were tested for breathing function, allergic sensitivity and Treg cells in the blood.

Daily air quality data came from California Air Resources Board monitoring stations. The researchers calculated each child's annual average exposure to polycyclic aromatic hydrocarbons (PAH), a byproduct of fossil fuel and a major pollutant in vehicle exhaust.

The study found that the annual average exposure to PAH was 7 times greater for the children in Fresno compared with the kids in Palo Alto. Levels of ozone and particulate matter were also significantly higher in Fresno.

Not surprisingly, the study found
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Contact: Sarah Yang
scyang@berkeley.edu
510-643-7741
University of California -- Berkeley
Source:Eurekalert

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