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Agios Pharmaceuticals' founders author Science review on cancer metabolism
Date:5/21/2009

Cambridge, MA May, 21, 2009 Agios Pharmaceuticals, the first biopharmaceutical company focused on discovering and developing novel cancer metabolism drugs, announced that the leading scientific journal Science has published a review article, "Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation," authored by two of its founders, Lewis C. Cantley, Ph.D., Director of the Cancer Center at Beth Israel Deaconess Medical Center and Professor of Systems Biology and Craig B. Thompson, M.D., Director, Abramson Cancer Center, University of Pennsylvania, and one of its scientific advisors, Matthew Vander Heiden, M.D., Ph.D., Instructor of Medicine, Dana Farber Cancer Institute and Harvard Medical School.

"As this review highlights, there is an incredible opportunity in front of us to bring together decades of independent cancer and metabolic scientific research into an integrated approach to novel cancer therapies," said Dr. Vander Heiden, Agios scientific advisor. "It is exciting to see the broad scientific engagement that is driving this field rapidly forward to ultimately provide new options for physician and their patients."

Cancer metabolism is a new and exciting field of biology that represents a breakthrough understanding of how cancer cells become addicted to using more nutrients than normal cells to ensure their survival and growth. The new understanding of a fundamental mechanism of cancer growth and survival represents a powerful Achilles' heel to target this deadly disease.

The Science review article summarizes the current state of the emerging biological field of cancer metabolism and suggests that "a better understanding of anabolic cellular metabolism and how growth control impacts its regulation may lead to new targets and improved therapy for human cancer." The review, which provides a meta-analysis of the field, highlights key advancements ranging from Otto Warburg's discovery
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Contact: Kathryn Morris
kathryn@kmorrispr.com
845-635-9828
Yates Public Relations
Source:Eurekalert

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