Navigation Links
Aging hepatitis C population escalates demand for liver transplantation
Date:12/6/2012

New research reveals that the greatest demand for liver transplantation due to hepatitis C (HCV)-related liver disease occurs among Americans born between 1941 and 1960. Findings in the December issue of Liver Transplantation, a journal published by Wiley on behalf of the American Association for the Study of Liver Diseases (AASLD), suggest that continuing increased demand for transplantation is driven by the development of liver cancer in baby boomers with HCV, but that the demand may decrease as patients born in this time period continue to grow older.

HCV is the most common blood-borne infection and cause of liver disease requiring transplantation in the U.S., chronically infecting more than one percent of Americans. Previous studies show that among patients living with chronic HCV, 10% to 20% will develop cirrhosis and up to 5% will progress to liver cancer (hepatocellular carcinoma; HCC). Further evidence implicates HCV as the primary risk factor for developing HCC in up to 47% of cases of patients with HCC.

The peak U.S. HCV prevalence of 4% occurred in those born in 1940 through 1965, who were 20 to 30 years of age during 1979 to 1989, when HCV infection risk was at its highest. As this population ages, Davis et al. project that between 2000 and 2030 cirrhosis in patients with HCV will increase two-fold, from 472,000 to 879,000. Moreover, Wise et al. suggests HCV-related deaths will increase in Americans 55 to 64 years of age by 2004.

"The dire projections in HCV complications spurred our investigation of age-specific trends in liver transplantation demand," said lead author Dr. Scott Biggins with the University of Colorado School of Medicine in Aurora, Colo. For the present study, researchers identified all adult liver transplant candidates who were registered with the Organ Procurement and Transplantation Network (OPTN) between 1995 and 2010. Patients were then classified with the diagnosis of HCV, with or without HCC.

Results show there were 126,862 new candidates for first liver transplant registered with OPTN, with 41% of these having HCV. Candidates were categorized by birth year and found that the highest HCV frequency (in decreasing order) were those born in 1951-1955, 1956-1960, 1946-1950, and 1941-1945. These four birth groups represent 81% of all new liver transplant registrants with HCV.

Furthermore, findings indicate that between 2000 and 2010 there was a four-fold increase in new transplant candidates with HCV and HCC in the 1941 to 1960 birth cohorts. The authors anticipate an increase in the proportion of new registrants, 60 years and older, with HCV will have liver cancer.

"Over the coming decade the aging of those infected with HCV will challenge the transplant community to reconsider current treatment plans given the projected increase in liver transplantation demand, particularly from patients with HCV and liver cancer," concludes Dr. Biggins. "With the aging of the population of patients with HCV, many of these patients may not be healthy enough for transplantation and the number of liver transplants in patients with HCV may decrease."


'/>"/>

Contact: Dawn Peters
sciencenewsroom@wiley.com
781-388-8408
Wiley
Source:Eurekalert

Related medicine news :

1. Vaccine yielded encouraging long-term survival rates in certain patients with NSCLC
2. Social ties have mixed impact on encouraging healthy behaviors in low-income areas
3. Live imaging shows response to cancer drugs can be boosted by altering tumor microenvironment
4. MR enterography is as good or better than standard imaging exams for pediatric Crohns patients
5. Use of dedicated pediatric imaging departments for pediatric CT reduces radiation dose
6. Joslin scientists identify important mechanism that affects the aging process
7. Low-dose whole-body CT finds disease missed on standard imaging for patients with multiple myeloma
8. Staging and risk stratification of thyroid cancer improved with SPECT/CT
9. Study examines necessity of additional imaging in PET/CT oncologic reports
10. Self-Managing COPD Might Pose Risks, Study Suggests
11. CNIO scientists successfully test the first gene therapy against aging-associated decline
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/25/2017)... Richmond, BC (PRWEB) , ... April 25, 2017 , ... ... patients from Richmond, BC, who live with dental fear and require sedation to receive ... anxiety at ease during various procedures, from hygienic cleanings to oral surgery, at ...
(Date:4/25/2017)... , ... April 25, 2017 , ... ... they rely on contracted partners to help with process innovation in drug formulation ... drug formulation experience along with state-of-the-art analytical equipment in support of their development ...
(Date:4/25/2017)... MN (PRWEB) , ... April 25, 2017 , ... Buyers ... and recreational users to dispensaries and head shops –can’t help but be heartened by ... for the tell-tale cannabis odor aptly described as “skunk smell.” At last they ...
(Date:4/25/2017)... ... 25, 2017 , ... Emergency Physician and Distinguished Professor of Emergency Medicine Bentley ... in Writing, set to publish in summer 2017. , Dr. Bobrow, MD, FACEP, ... Arizona College of Medicine. He also serves as Medical Director for the Bureau of ...
(Date:4/25/2017)... ... April 25, 2017 , ... Amendia, Inc., designer, developer, and ... partnership with and platinum sponsorship of Global Spine Outreach (“GSO”), a charitable organization ... of complex spine deformity cases, particularly in children. , GSO’s focus is to ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... April 19, 2017 Global Surgical Drainage Device ... tubes used to remove excess liquid and air. The ... urine, bile or lymph. Surgical drains are used in ... as orthopedics surgery, cardiovascular surgery, neurosurgery, plastic surgery etc. ... to prevent accumulation of fluid e.g. blood or pus. ...
(Date:4/19/2017)... 19, 2017  Sorrento Therapeutics, Inc. (NASDAQ: ... company developing new treatments for cancer and other ... its previously announced underwritten public offering of 23,625,084 ... offering price of $2.00 per share, before deducting ... payable by Sorrento.  The net proceeds to Sorrento ...
(Date:4/19/2017)... , April 19, 2017  SARES•REGIS Group ... it is developing at Conejo Spectrum Business Park ... to Atara Biotherapeutics, Inc. , a biopharmaceutical ... and life-threatening diseases that have been underserved by ... T-cell therapies for cancer, autoimmune and infectious disease. ...
Breaking Medicine Technology: