Navigation Links
Aging, obsolete cells prime the lungs for pneumonia
Date:5/26/2011

SAN ANTONIO (May 26, 2011) Community-acquired pneumonia is the leading cause of infectious death among the elderly. Newly published research from The University of Texas Health Science Center San Antonio suggests why older people are vulnerable and offers a possible defense.

The researchers found that when it comes to aging and pneumonia, one bad apple can ruin the barrel. Lung cells that were supposed to die due to DNA damage but didn't were 5 to 15 times more susceptible to invasion by pneumonia-causing bacteria. These bad apples also increased the susceptibility of normal cells around them. The research was published Wednesday [May 25] in the journal Aging Cell.

Close to 1 billion adults worldwide are at risk for pneumonia. They include more than 800 million adults who are older than 65 and an estimated 210 million with chronic obstructive pulmonary disease (COPD).

Injurious effects

Both age and COPD are associated with senescent cells, which are unable to die due to dysregulated function. These cells have increased levels of proteins that disease-causing bacteria stick to and co-opt to invade the bloodstream. The cells also spew out molecules that increase inflammation, and make normal cells nearby do the same.

"Senescent cells prime the lungs for infection," said Pooja Shivshankar, Ph.D., research scientist in microbiology and immunology at the UT Health Science Center and first author on the study.

Controlling the inflammatory molecules' release could short-circuit pneumonia risk in the elderly, said the senior author, Carlos Orihuela, Ph.D., assistant professor of microbiology and immunology, also at the Health Science Center.

"We can't stop aging, but our findings suggest that preventing inflammation might be the next best thing," Dr. Orihuela said. "This opens up possibilities for anti-inflammatory drugs as treatments for pneumonia."

Mouse study

The scientists compared aged and young mice, all healthy. The older mice were found to have increased lung inflammation with higher levels of senescence markers; this was consistent with previous studies in the literature.

The lung cells in aged mice also proved to be more susceptible to infection by Streptococcus pneumonia, the bacterium that causes pneumonia. This was determined by increased levels of proteins to which the bacteria adhere and by testing bacterial adhesion to the lung cells.

Four different experiments on senescent cells, on normal lung cells exposed to senescent cells, on aged mice and on young mice exposed to gene-damaging stress revealed increased susceptibility to pneumonia infection.

"This potentially helps to explain why the elderly and individuals with COPD are predisposed to community-acquired pneumonia," Dr. Orihuela said.


'/>"/>

Contact: Will Sansom
sansom@uthscsa.edu
210-567-2579
University of Texas Health Science Center at San Antonio
Source:Eurekalert  

Related medicine news :

1. Statement from Larry Minnix, President & CEO, American Association of Homes and Services for the Aging, on President Obamas Health Care Reform Proposal
2. Statement from Larry Minnix, President & CEO, American Association of Homes and Services for the Aging, On the Therapy Cap Coalition Press Conference
3. Statement From Larry Minnix, President & CEO, American Association of Homes and Services for the Aging, on the Beginning of the Reconciliation Process for Health Reform Legislation
4. "Zerona" Lipo-Laser Penetrates Wellness Industry for Anti-aging, Weight Loss, Body Sculpting and Cardiac Health
5. Brief Exercise Reduces Impact of Stress on Cell Aging, UCSF Study Shows
6. Accelarad Partners with Visage Imaging, Inc. To Enhance Its Next Generation Medical Image Exchange Solution
7. Volumetrics Medical Imaging, LLC and Medison Co., Ltd. Announce Technology License and Settlement of Patent Litigation
8. Dr. Harold G. Koenig to speak at R.J. DeBottis Lecture on Aging, Nov. 8
9. Brain bleeding is common with aging, UCI study finds
10. Clinical decision support systems help control inappropriate medical imaging, study suggests
11. New Study Uses Adult Stem Cells in Effort to Save Limbs of Patients with Peripheral Arterial Disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Aging, obsolete cells prime the lungs for pneumonia
(Date:8/22/2017)... ... August 22, 2017 , ... “Glimpses Of Light”: ... the world. “Glimpses Of Light” is the creation of published author, J.M. Shepherd, a ... search of answers to life’s perplexing mysteries. , Shepherd shares, “Love is one of ...
(Date:8/22/2017)... (PRWEB) , ... August 22, 2017 , ... “Call Of ... Duty” is the creation of published author, C.S. Lizarde. Growing up on the ... untimely trials. When Carlos began to apply the Biblical keys to his life, ...
(Date:8/21/2017)... ... August 22, 2017 , ... ... risk to health and safety. By learning and implementing best practices for containment ... In this webinar, attendees will gain a better understanding of a method for ...
(Date:8/21/2017)... ... August 21, 2017 , ... FCPX LUT Monochromatic Volume 2 is ... and easily add washed color grades to footage. A LUT is a Lookup Table ... color to the corresponding color indicated by the table. This pack comes with 60 ...
(Date:8/21/2017)... ... August 21, 2017 , ... ... place all over the country. , Outdoor running increases exposure to ultraviolet radiation, ... an increased risk of melanoma, and only half may be adequately protecting themselves ...
Breaking Medicine News(10 mins):
(Date:8/8/2017)... 2017   Second-quarter ... (GAAP) loss per share from continuing operations ... increased 16 percent to $110 million ... percent to $161 million ... continuing operations increased 8 percent to $0.93 ...
(Date:8/7/2017)... (NYSE: DPLO), the nation,s largest independent specialty pharmacy, announced financial ... unless otherwise noted, are to the quarter ended June 30, ... 2017 Highlights include: Revenue of $1,126 ... Total prescriptions dispensed of 220,000, compared to 241,000 ... Gross profit per prescription dispensed of $371, ...
(Date:8/3/2017)... -- Opioid addiction and other drugs of abuse, blood poisoning ... outcomes, were problems taken on directly as laboratory professionals, ... them, met this week. This according to Kalorama Information. ... abuse, procalcitonin and acute kidney injury were key focuses ... in San Diego, CA.  Mechanisms ...
Breaking Medicine Technology: