Navigation Links
Aging, obsolete cells prime the lungs for pneumonia
Date:5/26/2011

SAN ANTONIO (May 26, 2011) Community-acquired pneumonia is the leading cause of infectious death among the elderly. Newly published research from The University of Texas Health Science Center San Antonio suggests why older people are vulnerable and offers a possible defense.

The researchers found that when it comes to aging and pneumonia, one bad apple can ruin the barrel. Lung cells that were supposed to die due to DNA damage but didn't were 5 to 15 times more susceptible to invasion by pneumonia-causing bacteria. These bad apples also increased the susceptibility of normal cells around them. The research was published Wednesday [May 25] in the journal Aging Cell.

Close to 1 billion adults worldwide are at risk for pneumonia. They include more than 800 million adults who are older than 65 and an estimated 210 million with chronic obstructive pulmonary disease (COPD).

Injurious effects

Both age and COPD are associated with senescent cells, which are unable to die due to dysregulated function. These cells have increased levels of proteins that disease-causing bacteria stick to and co-opt to invade the bloodstream. The cells also spew out molecules that increase inflammation, and make normal cells nearby do the same.

"Senescent cells prime the lungs for infection," said Pooja Shivshankar, Ph.D., research scientist in microbiology and immunology at the UT Health Science Center and first author on the study.

Controlling the inflammatory molecules' release could short-circuit pneumonia risk in the elderly, said the senior author, Carlos Orihuela, Ph.D., assistant professor of microbiology and immunology, also at the Health Science Center.

"We can't stop aging, but our findings suggest that preventing inflammation might be the next best thing," Dr. Orihuela said. "This opens up possibilities for anti-inflammatory drugs as treatments for pneumonia."

Mouse study

The scientists compared aged and young mice, all healthy. The older mice were found to have increased lung inflammation with higher levels of senescence markers; this was consistent with previous studies in the literature.

The lung cells in aged mice also proved to be more susceptible to infection by Streptococcus pneumonia, the bacterium that causes pneumonia. This was determined by increased levels of proteins to which the bacteria adhere and by testing bacterial adhesion to the lung cells.

Four different experiments on senescent cells, on normal lung cells exposed to senescent cells, on aged mice and on young mice exposed to gene-damaging stress revealed increased susceptibility to pneumonia infection.

"This potentially helps to explain why the elderly and individuals with COPD are predisposed to community-acquired pneumonia," Dr. Orihuela said.


'/>"/>

Contact: Will Sansom
sansom@uthscsa.edu
210-567-2579
University of Texas Health Science Center at San Antonio
Source:Eurekalert  

Related medicine news :

1. Statement from Larry Minnix, President & CEO, American Association of Homes and Services for the Aging, on President Obamas Health Care Reform Proposal
2. Statement from Larry Minnix, President & CEO, American Association of Homes and Services for the Aging, On the Therapy Cap Coalition Press Conference
3. Statement From Larry Minnix, President & CEO, American Association of Homes and Services for the Aging, on the Beginning of the Reconciliation Process for Health Reform Legislation
4. "Zerona" Lipo-Laser Penetrates Wellness Industry for Anti-aging, Weight Loss, Body Sculpting and Cardiac Health
5. Brief Exercise Reduces Impact of Stress on Cell Aging, UCSF Study Shows
6. Accelarad Partners with Visage Imaging, Inc. To Enhance Its Next Generation Medical Image Exchange Solution
7. Volumetrics Medical Imaging, LLC and Medison Co., Ltd. Announce Technology License and Settlement of Patent Litigation
8. Dr. Harold G. Koenig to speak at R.J. DeBottis Lecture on Aging, Nov. 8
9. Brain bleeding is common with aging, UCI study finds
10. Clinical decision support systems help control inappropriate medical imaging, study suggests
11. New Study Uses Adult Stem Cells in Effort to Save Limbs of Patients with Peripheral Arterial Disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Aging, obsolete cells prime the lungs for pneumonia
(Date:1/24/2017)... ... January 23, 2017 , ... The January 2017 issue of the Journal ... on how outdoor behavioral healthcare (OBH) – also known as wilderness therapy – helped ... experiencing an increased sense of purpose both during and after treatment. , The ...
(Date:1/24/2017)... Ariz. (PRWEB) , ... January 23, 2017 , ... ... recently analyzed statistics from 140 Buzzies users who entered metrics into the product’s ... earlier clinical data. The new data showed that within just 30 seconds of ...
(Date:1/24/2017)... Clara, CA (PRWEB) , ... January 23, 2017 ... ... announces the launch of a new plugin that allows sleep centers to automatically ... Sleep Device Interface (SDI)—is a thin client browser plugin is quickly installed on ...
(Date:1/23/2017)... ... January 23, 2017 , ... A Northwestern Pennsylvania addiction ... address. Alpine Springs Rehabilitation & Recovery Center’s new website can be found at ... with its redesigned and retooled website. The treatment center has also revamped its ...
(Date:1/23/2017)... ... January 23, 2017 , ... ... for life science companies, has achieved ISO 17100:2015 certification following a comprehensive ... 17100 is the globally recognized standard that establishes guidance for critical processes ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... Longer life expectancy and rising healthcare expenditure in developing countries are ... BCC Research reveals in its new report that markets in ... see strong growth due to rising government healthcare spending, increased levels of ... Continue Reading ... ...
(Date:1/23/2017)... Spain , January 23, 2017 /PRNewswire/ ... biopharmaceutical company focused on treatments for calcification disorders, ... enrolled in the Phase IIb "CaLIPSO Study" clinical ... of cardiovascular calcification (CVC) in end-stage-renal-disease (ESRD) patients ... in the last stage of chronic kidney disease, ...
(Date:1/22/2017)... , Saudi Arabia , January 22, 2017 ... US and UAE discuss ... at the World Economic Forum   "The management and ... big data and powered by artificial intelligence and this trend is going to ... ,Hospital of the Future, at the concluding day of the 47 th ...
Breaking Medicine Technology: