Navigation Links
Aggressive treatment of psoriatic arthritis results in 'significant' improvement, says new research
Date:10/28/2013

People with a type of arthritis affecting the skin and joints respond significantly better to early, aggressive drug treatment compared to standard care, according to preliminary results presented by a University of Leeds lecturer to a major US conference.

Dr Philip Helliwell, who is leading an Arthritis Research UK-funded multi-centre clinical trial into psoriatic arthritis, revealed today (Monday October 28) at the prestigious American College of Rheumatology Congress in San Diego that patients benefited from a rapid escalation of medication.

Psoriatic arthritis perhaps best known for being the condition Michael Gambon's character suffered from in the television programme, The Singing Detective affects the joints and the skin, causing joint pain and swelling, leading to joint damage and disability over time.

Although better drugs are now available to treat the condition than in the past, Dr Helliwell and his team believe that earlier, intensive treatment of the condition can reduce joint damage more effectively, preventing disability.

"We have found that tight control of disease activity in psoriatic arthritis, using a targeted approach, significantly improves the joint and skin outcomes for newly diagnosed patients with no unexpected side-effects," said Dr Helliwell, Senior Lecturer in Rheumatology and a leading UK authority in psoriatic arthritis.

Dr Helliwell and his colleague Dr Laura Coates from the Leeds Institute of Rheumatic and Musculoskeletal Medicine, spearheaded a 550,000 national clinical trial, involving more than 200 patients, based at Chapel Allerton Hospital in Leeds.

They compared intensive early treatment carried out in specialist clinics with the kind of care patients usually receive, to find out which group of patients do better over a year.

"We predicted that a tighter, more aggressive treatment of psoriatic arthritis in which patients are given escalating dosages of drugs if their condition is not responding, and who then see a specialist every month with the aim of controlling their symptoms fully and as soon as possible, would result in a good outcome after 12 months," explained Dr Helliwell.

"That has proven to be the case. These findings could have significant implications for the way that this common type of inflammatory arthritis is treated and controlled."

Medical director of Arthritis Research UK, Professor Alan Silman, said: "Patients with psoriatic arthritis in general have fewer affected joints than those with rheumatoid arthritis, but there are sub-groups of patients who suffer a very severe form with a significant risk of irreversible, joint damage.

"Research in this disorder has lagged behind rheumatoid arthritis research, although patients have similar levels of disability and reduction in quality of life. In addition, they have to cope with often very severe skin problems and arthritis affecting the spine.

"Our trial has shown that patients with psoriatic arthritis benefit from early aggressive treatment that reduces the inflammation in the joints. Such an approach proved successful in the treatment of rheumatoid arthritis and this research could lead to a similar change in the way psoriatic arthritis patients are managed in the future."


'/>"/>

Contact: Ben Jones
B.P.Jones@leeds.ac.uk
University of Leeds
Source:Eurekalert

Related medicine news :

1. CNIO scientists reduce progression of one of the most aggressive skin cancers in mice
2. Chronic aggressive behavior in boys: Epigenetic sources?
3. Researchers to identify genetic biomarkers for aggressive breast cancer
4. Severity of sleep apnoea predicts aggressiveness of melanoma
5. Inflammatory protein converts glioblastoma cells into most aggressive version
6. Study finds tumor suppressor may actually fuel aggressive leukemia
7. Chromosome 21 abnormality tells oncologists to treat pediatric ALL more aggressively
8. Targeting aggressive prostate cancer
9. Thomas Jefferson University Kimmel Cancer Center: Researchers Find New Clues to Treat Rare and Aggressive Inflammatory Breast Cancer
10. Could sleeping stem cells hold key to treatment of aggressive blood cancer?
11. Active surveillance may miss aggressive prostate cancers in black men
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/28/2017)... , ... June 28, 2017 , ... ... announce that its 50ml Liquid Stevia Sweet Drops™ have received the Non-GMO Project ... verification process from the Non-GMO Project, the only third-party verification for non-GMO foods ...
(Date:6/28/2017)... ... 28, 2017 , ... Anyone with a remote control has seen the never-ending twists on the ... flipper will get rich in no time. But what about the buyers of the ... the buyer of a flipped house. An email recently sent to Gary Case said, ...
(Date:6/28/2017)... ... June 28, 2017 , ... American Farmer proudly announces the participation of ... winning television series, scheduled to broadcast fourth quarter 2017. American Farmer airs Tuesdays at ... supplier of garden pea seed. As demand grew, the small company located in Moscow, ...
(Date:6/28/2017)... Cincinnati, OH (PRWEB) , ... June 28, 2017 ... ... residents of Hamilton County and the surrounding regions access to insurance assistance and ... conjunction with Matthew 25: Ministries to assist families in the region facing financial ...
(Date:6/27/2017)... ... June 27, 2017 , ... Nearly ... to survey data released today by the American Society for Dermatologic Surgery ... indicates the percentage of consumers considering a cosmetic medical procedure has doubled since ...
Breaking Medicine News(10 mins):
(Date:5/26/2017)... International plc (NASDAQ: ENDP ) announced today that ... Company in a fireside chat at Goldman Sachs, 38 th ... at 10:40 a.m. PT / 1:40 p.m. ET. The conference ... Palos Verdes, CA. A live webcast ... the Company,s website at http://www.endo.com/investors/overview . Participants should allow ...
(Date:5/24/2017)... , May 24, 2017  ivWatch LLC ... Equipment Manufacturer (OEM) Board to enable seamless integration ... patient monitoring systems, infusion pumps and other devices. ... will be able to help health care customers ... reduced risks related to IV therapy. ...
(Date:5/22/2017)... VALLEY COTTAGE, N.Y. , May 22, 2017 ... natural antiviral treatment Gene-Eden-VIR/Novirin, announces the launch of ... in plain English, the results of a clinical ... after one year treatment with Gene-Eden-VIR/Novirin in individuals ... is important to note that there are no ...
Breaking Medicine Technology: