Navigation Links
Aggressive drug therapy aids superbug evolution
Date:8/3/2011

New research raises troubling concerns about the use of aggressive drug therapies to treat a wide range of diseases such as MRSA, C. difficile, malaria, and even cancer.

"The universally accepted strategy of aggressive medication to kill all targeted disease pathogens has the problematic consequence of giving any drug-resistant disease pathogens that are present the greatest possible evolutionary advantage," says Troy Day, one of the paper's co-authors and Canada Research Chair in Mathematical Biology at Queen's.

The researchers note that while the first aim of a drug treatment program should be to make and keep a patient healthy, the patient's immune system also has to be allowed to work.

They suggest several strategies to address the challenge of drug-resistant pathogens including improving the current knowledge base, discovering effective ways for slowing the spread of drug-resistant pathogens from person-to-person, and developing strategies for preventing drug-resistant mutations from occurring in the first place.

Last century's malaria wonder drug, chloroquine, is a perfect example of aggressive medication leading to the growth of drug-resistant pathogens. Since drug-resistant malarial parasites didn't have to compete with parasites that were killed off by an aggressive chloroquine treatment plan, the resistant parasites were given an evolutionary advantage. As a treatment for malaria, chloroquine is now useless across most of Africa.

"As things currently stand, no research exists that can tell us what the optimal drug delivery strategy would be for maintaining treatment effectiveness and mitigating the evolution of resistance," says Dr. Day. "While overwhelming medicinal force may sometimes be required, we need to be clear about when and why this strategy should be chosen since it brings with it some very clear problems with respect to resistance evolution."


'/>"/>

Contact: Christina Archibald
christina.chant@queensu.ca
613-533-2877
Queen's University
Source:Eurekalert

Page: 1

Related medicine news :

1. New anti-cancer agents show promise for treating aggressive breast cancers
2. Scientists identify a novel mechanism for evolution of highly aggressive cancers
3. FDA Approves Test That Spots Aggressive Breast Cancer
4. Drugs for Enlarged Prostate May Raise Risk of Aggressive Cancer
5. Scientists identify overactive genes in aggressive breast cancers
6. Kids who bully, are aggressive are twice as likely to have sleep problems
7. Violent video games reduce brain response to violence and increase aggressive behavior
8. Are Coffee Drinkers Less Prone to Aggressive Breast Cancer?
9. Aggressive Treatment May Be Beneficial for Early Prostate Cancer
10. Tumors Spotted Between Mammograms Often More Aggressive: Study
11. Low Vitamin D Levels Linked to More Aggressive Breast Cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2017)... Bradley, Illinois (PRWEB) , ... May 26, 2017 , ... ... , The community, which is located on more than four acres of land at ... their independence. , The 103,000 square-foot building includes 125 studio and one-bedroom apartments. ...
(Date:5/26/2017)... ... May 26, 2017 , ... Centennial-based ... of proceeds from its 14th Annual Clays for Kids fundraiser, to be held ... Bennett, Colorado. , As part of BluSky’s partnership with The Adoption Exchange, ...
(Date:5/24/2017)... Yorba Linda, Ca (PRWEB) , ... May 24, ... ... discriminating between effects and background. Understanind and choosing the most appropriate instruments for ... will prove critical in research finding. This webinar will focus on innovations in ...
(Date:5/24/2017)... (PRWEB) , ... May 24, 2017 , ... Dr. Manju ... comfortable ClearCorrect orthodontics, with or without a referral. Dr. Kejriwal understands the ... she offers convenient, clear braces in Cincinnati, OH. Patients no longer need to feel ...
(Date:5/24/2017)... ... May 24, 2017 , ... ... female reproductive tract in which the endometrial lining of the uterus spreads ... and pain. Patients experiencing painful intercourse, painful periods, pelvic pain, or irregular ...
Breaking Medicine News(10 mins):
(Date:5/4/2017)... MEMPHIS, Tenn. , May 4, 2017 /PRNewswire/ ... of Infection Control, Ultraviolet-C light as ... demonstrated Tru-D SmartUVC,s ability to reduce bioburden on ... influenced bioburden reduction on high-touch, complex medical equipment ... in surgical infections. "This study further ...
(Date:5/4/2017)... , May 4, 2017  A new tight-tolerance ... and other highly-engineered materials, is being launched by ... has been developed in recent years to service ... and surgical applications. More expensive materials such as ... microextrusion tubing due to their ability to consistently ...
(Date:5/3/2017)... , May 3, 2017  Getinge, a ... contribute to quality enhancement and cost efficiency within ... a study of contemporary practice demonstrating that intra-aortic ... therapy for critically ill patients. The single-center, retrospective, ... newer large volume MEGA ® 50cc intra-aortic ...
Breaking Medicine Technology: