Navigation Links
Aggression as rewarding as sex, food and drugs
Date:1/14/2008

NASHVILLE, Tenn.New research from Vanderbilt University shows for the first time that the brain processes aggression as a reward - much like sex, food and drugs - offering insights into our propensity to fight and our fascination with violent sports like boxing and football.

The research will be published online the week of Jan. 14 by the journal Psychopharmacology.

Aggression occurs among virtually all vertebrates and is necessary to get and keep important resources such as mates, territory and food, Craig Kennedy, professor of special education and pediatrics, said. We have found that the reward pathway in the brain becomes engaged in response to an aggressive event and that dopamine is involved.

It is well known that dopamine is produced in response to rewarding stimuli such as food, sex and drugs of abuse, Maria Couppis, who conducted the study as her doctoral thesis at Vanderbilt, said. What we have now found is that it also serves as positive reinforcement for aggression.

For the experiments, a pair of mice - one male, one female - was kept in one cage and five intruder mice were kept in a separate cage. The female mouse was temporarily removed, and an intruder mouse was introduced in its place, triggering an aggressive response by the home male mouse. Aggressive behavior included tail rattle, an aggressive sideways stance, boxing and biting.

The home mouse was then trained to poke a target with its nose to get the intruder to return, at which point it again behaved aggressively toward it. The home mouse consistently poked the trigger, which was presented once a day, indicating it experienced the aggressive encounter with the intruder as a reward.

The same home mice were then treated with a drug that suppressed their dopamine receptors. After this treatment, they decreased the frequency with which they instigated the intruders entry.

In a separate experiment, the mice were treated with the dopamine receptor suppressors again and their movements in an open cage were observed. They showed no significant changes in overall movement compared to times when they had not received the drugs. This was done to demonstrate that their decreased aggression in the previous experiment was not caused by overall lethargy in response to the drug, a problem that had confounded previous experiments.

The Vanderbilt experiments are the first to demonstrate a link between behavior and the activity of dopamine receptors in response to an aggressive event.

We learned from these experiments that an individual will intentionally seek out an aggressive encounter solely because they experience a rewarding sensation from it, Kennedy said. This shows for the first time that aggression, on its own, is motivating, and that the well-known positive reinforcer dopamine plays a critical role.


'/>"/>

Contact: Melanie Moran
melanie.moran@vanderbilt.edu
615-322-2706
Vanderbilt University
Source:Eurekalert

Related medicine news :

1. Aggression in adolescents is influenced by siblings
2. Older Brothers Might Spur Kids Aggression
3. Watching Violent TV at Pre-School Age Linked to Aggression in Young Boys
4. TV Violence May Spur Aggression in Boys
5. Pheromones identified that trigger aggression between male mice
6. Scripps research scientists discover chemical triggers for aggression in mice
7. Massachusetts Employers and Health Plans Continue to Support Quality Care by Rewarding Physicians through Bridges to Excellence Programs
8. New review suggests caution on drugs to raise good cholesterol
9. Can cancer drugs combine forces?
10. Study provides hope that some transplant patients could live free of antirejection drugs
11. Study provides hope that some transplant patients could live free of anti-rejection drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... ... January 23, 2017 , ... Texas Home Health, an ... two personal care service companies: Padre Home Health in Corpus Christi, Texas, and ... , Well regarded in their respective markets, these two agencies align with Texas ...
(Date:1/24/2017)... Clara, CA (PRWEB) , ... January 23, 2017 ... ... announces the launch of a new plugin that allows sleep centers to automatically ... Sleep Device Interface (SDI)—is a thin client browser plugin is quickly installed on ...
(Date:1/23/2017)... ... January 23, 2017 , ... PKF O’Connor Davies ... J. Nelson, a senior accountant at the Firm, will participate in the 40th Annual ... Over 200 runners will race up 1,576 steps, a vertical distance equal to about ...
(Date:1/23/2017)... (PRWEB) , ... January 23, 2017 , ... ... the highly acclaimed series, Innovations with Ed Begley, Jr., scheduled to broadcast Saturday, ... technology behind SmartCap, which was founded in 2008 to address the limitations of ...
(Date:1/23/2017)... ... January 23, 2017 , ... The Masters ... management and evaluation leaders with decades of experience who remain current practitioners in ... States healthcare system, there is a renewed demand for versatile, data-driven leadership.The American ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)... -- The global peripheral I.V. catheter market accounted for ... to grow at a CAGR of 6.0% during 2016-2022. ... share in the global market between the two types ... hospital segment accounted for the highest share in the ... I.V. catheter market is witnessing high growth rate, due ...
(Date:1/23/2017)... Endo International plc (NASDAQ / TSX: ENDP) and the ... motion in the U.S. District Court for the Northern ... entry of a ten-year Stipulated Order for Permanent Injunction.  ... and Endo relating to the patent infringement settlements Endo ... Lidoderm® products.  It also resolves the FTC,s claims against ...
(Date:1/23/2017)... MouthWatch LLC announced today that its flagship product, ... best intraoral camera on DentalCompare,s list of Top Dental ... #1 product was the CollaPlug Absorbable Collagen Wound Dressing ... "…incredibly popular because it is by far the most economical ... price, it doesn,t sacrifice quality imaging." ...
Breaking Medicine Technology: