Navigation Links
Agent selectively targets malignant B cells in chronic leukemia, study shows
Date:5/3/2011

COLUMBUS, Ohio A new experimental drug selectively kills the cancerous cells that cause chronic lymphocytic leukemia, according to a new study by researchers at the Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James).

The study shows that the experimental agent PCI-32765 selectively kills the malignant B lymphocytes that cause chronic lymphocytic leukemia (CLL).

The researchers say the findings, published online in the journal Blood, are important because current CLL therapies kill T lymphocytes along with the cancerous B lymphocytes.

T lymphocytes and B lymphocytes make up the adaptive immune system. When CLL treatment destroys them both, patients become highly susceptible to life-threatening infections.

"A drug that kills malignant B lymphocytes and spares T lymphocytes could dramatically improve outcomes for CLL patients," says study leader Dr. John C. Byrd, director, division of hematology and professor of medicine, of medicinal chemistry and of veterinary biosciences at the OSUCCC James.

"Our collective results indicate that PCI-32765 is an outstanding candidate for further development as a therapeutic for CLL," says study co-director Dr. Amy J. Johnson, assistant professor of hematology and medicinal chemistry, and a CLL researcher with the OSUCCC-James.

The research by Byrd, Johnson and a group of colleagues used CLL cells from ten patients. It had several key findings related to PCI-32765:

  • The agent specifically targets an important signaling molecule called Bruton's tyrosine kinase, which is overexpressed in CLL cells and absent in T cells.
  • The agent inhibits the proliferation of CLL cells in laboratory culture and promotes their death by self-destruction (apoptosis).
  • It blocks survival signals from cells in the surrounding microenvironment, including soluble factors such as IL-6, IL-4, an
    '/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Professional Insurance Agents to Hold 2010 Federal Legislative Summit March 17-18
2. Long Term Care Insurance Leader Seeks 320 New Agents in 2010, Following Strong 2009 Growth
3. Professional Insurance Agents Name Rep. Charlie Melancon 2010 Legislator of the Year
4. Overcoming tumor resistance to anti-cancer agent TRAIL
5. Scott & White Healthcare researchers studying investigational agent that targets breast cancer
6. Targeted agent blocked growth of deadly brain cancer in preclinical studies
7. New agent chokes off energy supply, kills cancer cells
8. Health Insurance Agents Work with Zane Benefits to Offer New Solutions amid Health Care Reform
9. Mayo-led research team develop agents that keep insulin working longer
10. Shark cartilage shows no benefit as a therapeutic agent for lung cancer
11. Compound enhances cancer-killing properties of agent in trials
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2015)... “ BolehVPN ” was featured on NewsWatch as ... and coolest technology products available to consumers. Scott Steinberg, a ... and shared with viewers how to protect their private information. ... on computers and even more so online. It helps everyone ... over the world. In terms of work, the internet makes ...
(Date:5/3/2015)... May 03, 2015 SpineFrontier, a Less ... the FDA to produce and market their new sacroiliac ... be used in outpatient settings and is compatible with ... posterior approach has been extensively researched and refined by ... to use this approach in conjunction with a sacroiliac ...
(Date:5/2/2015)... As one of only 30 Illinois companies to be ... and Recognition Program (SHARP) certification, Essentra Specialty Tapes ... Department of Labor to host this special event. ... the Occupational Safety and Health Administration’s (“OSHA”) Onsite Consultation ... or exceed all of the necessary regulations and standards, ...
(Date:5/2/2015)... “ ActOn ” was featured on NewsWatch ... at the latest and coolest applications on the market for ... and technology expert, conducted the app review and shared with ... organizations to make a difference. , In this material world, ... that aren’t about money, which is why those things should ...
(Date:5/2/2015)... We are pleased to announce the Sun ... one of the Top Workplaces of 2015. , The ... field for their ethics and standards of excellence. The ... their educational efforts. The Delray Recovery Center prides itself ... purpose – to help individuals heal from the disease ...
Breaking Medicine News(10 mins):Health News:A Method to Keep Private Information Secure was Featured on NewsWatch Television 2Health News:Essentra Specialty Tapes is Selected to Host Gov. Rauner and the Workers' Memorial Day Celebration 2Health News:Essentra Specialty Tapes is Selected to Host Gov. Rauner and the Workers' Memorial Day Celebration 3Health News:An Application to Help People Make a Difference Was Featured on NewsWatch Television 2Health News:The Delray Recovery Center Named 2015 Top Workplace 2
... factors for spontaneous or unexpected preterm birth any birth ... without a known cause is already having had one. ... this scenario in their second pregnancy, focusing on weight gain ... new study reported at the Society for Maternal-Fetal Medicine,s annual ...
... HealthDay Reporter , THURSDAY, Feb. 9 (HealthDay News) -- A ... had chemotherapy while pregnant aren,t at higher risk for a ... be safe for the fetus in most instances. There,s ... were more likely to be born prematurely, potentially putting them ...
... Annual Meeting of the American Academy of Orthopaedic Surgeons ... living with a total knee replacement (TKR), as the ... the past decade, with the sharpest rise among younger ... TKR., Investigators used a computer model; U.S. Census data; ...
... (February 10, 2012) In a study to be ... meeting, The Pregnancy Meeting , in Dallas, Texas, researchers ... can be used to diagnose fetal aneuploidies, including Down ... Because of the importance of the clinical data, the ...
... obstructive sleep apnea had substantial improvements in attention, anxiety ... pressure (PAP)a nighttime therapy in which a machine delivers ... nose. "The benefits occurred even when children ... Carole L. Marcus, M.D., a sleep specialist and director ...
... , THURSDAY, Feb. 9 (HealthDay News) -- Small, premature ... higher risk for serious breathing problems than those delivered ... syndrome, which mostly affects premature newborns and can lead ... more common in the babies born by cesarean, or ...
Cached Medicine News:Health News:To avoid early labor and delivery, weight and diet changes not the answer 2Health News:Chemo During Pregnancy Doesn't Seem to Harm Baby 2Health News:Chemo During Pregnancy Doesn't Seem to Harm Baby 3Health News:4.5 million Americans living with total knee replacement 2Health News:Study finds massively parallel sequencing can detect fetal aneuploidies, including Down syndrome 2Health News:Sleep breathing machine shows clear benefits in children with sleep apnea 2Health News: C-Sections Might Put Preemies at Risk for Breathing Problems 2Health News: C-Sections Might Put Preemies at Risk for Breathing Problems 3
(Date:5/1/2015)... N.C. , May 1, 2015  An ... that can provide non-binding but informed guidance to ... the return on investment, it is important for ... invest optimal resources. Research and ... study to assist pharmaceutical and medical device executives ...
(Date:5/1/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/vzcw2v/americas_clinical ) has announced ... by Product, by End-Users - Forecast to 2019" report ... market is estimated to grow at a CAGR of 5.2% ... Canada , Mexico , ... covered in this report. The Americas is the ...
(Date:5/1/2015)... 2015 Following yesterday,s release of Center for Medicaid ... five things you need to know: ... unique among government programs. ... than other parts of Medicare and other government programs because ... to offer prescription drug benefits to enrollees. , Competition ...
Breaking Medicine Technology:New Study Presents Insights to Advisory Board Effectiveness in the Pharmaceutical Sector 2Americas Clinical Chemistry Analyzer (Semi-Automated Clinical Chemistry and Fully-Automated Clinical Chemistry) Market - Forecast to 2019 25 Things to Know About the CMS Part D Data Release 25 Things to Know About the CMS Part D Data Release 3
... 1, 2012 The FDA and representatives from the ... on proposed recommendations for the third reauthorization of a ... http://photos.prnewswire.com/prnh/20090824/FDALOGO ) The recommendations would authorize the ... five years, plus adjustments for inflation. Details of the ...
... Corporation (NYSE: BSX ) announces first ... PROMUS Element™ Plus Everolimus-Eluting Platinum Chromium Coronary Stent ... the new device was performed by Professor Antonio ... at Columbus Hospital and San Raffaele Hospital in ...
Cached Medicine Technology:FDA and Industry Reach Agreement in Principle on Medical Device User Fees 2FDA and Industry Reach Agreement in Principle on Medical Device User Fees 3Boston Scientific Announces First Implant and Market Launch of PROMUS Element™ Plus Stent System in Europe 2Boston Scientific Announces First Implant and Market Launch of PROMUS Element™ Plus Stent System in Europe 3Boston Scientific Announces First Implant and Market Launch of PROMUS Element™ Plus Stent System in Europe 4
... Many special order products are offered as ... long lengths. The modular instruments may be ... options such as ratchets, insulation and flush ... Mediflex stock. Customer specifications may affect delivery ...
... Many special order products are offered as ... long lengths. The modular instruments may be ... options such as ratchets, insulation and flush ... Mediflex stock. Customer specifications may affect delivery ...
... are offered as 1-piece or modular, in ... instruments may be customized with handles of ... insulation and flush ports. Many standard patterns ... may affect delivery times. , Please ...
... offered as 1-piece or modular, in regular ... may be customized with handles of choice ... and flush ports. Many standard patterns are ... affect delivery times. , Please Note: ...
Medicine Products: