Navigation Links
Agent Orange linked to skin cancer risk, reports Plastic and Reconstructive Surgery
Date:1/28/2014

Philadelphia, Pa. (January 28, 2014) Vietnam War veterans with prior exposure to the herbicide Agent Orange may be at higher risk for certain types of skin cancer, suggests a report in the February issue of Plastic and Reconstructive Surgery, the official medical journal of the American Society of Plastic Surgeons (ASPS).

The study adds to previous evidence that risk of non-melanotic invasive skin cancer (NMISC) is increased even four decades after Agent Orange exposure, with at least some exposed veterans having unusually aggressive non-melanoma skin cancers. The lead author was ASPS Member Surgeon Dr. Mark W. Clemens of The University of Texas MD Anderson Cancer Center and colleagues.

Skin Cancers Present in About Half of Vets Exposed to Agent Orange

During the Vietnam War, Agent Orange was widely used as herbicide and jungle defoliant. It has been linked to a wide range of cancers and other diseases, caused by the highly toxic dioxin contaminant TCDD. "TCDD is among the most carcinogenic compounds ever to undergo widespread use in the environment," according to Dr. Clemens and coauthors. Veterans Affairs recognizes and provides benefits for certain cancers and health problems associated with prior dioxin exposure during military service, however skin cancer is currently not one of them.

The researchers analyzed medical records of 100 consecutive men who enrolled in the Agent Orange registry at the Veterans Affairs Hospital of Washington, DC, between August 2009 and January 2010. Exposure to TCDD consisted of living or working in contaminated areas for 56 percent of veterans, actively spraying Agent Orange in 30 percent, and traveling in contaminated areas for 14 percent. The study was limited to men with lighter skin types.

The rate of NMISC in TCDD-exposed veterans was 51 percentabout twice as high as the rate expected in men of similar age group. The risk of skin cancer increased to 73 percent for veterans who actively sprayed Agent Orange. Exposed men with the lightest skin types and those with lighter eyes were also at higher risk.

Forty-three percent of the veterans had chloracne, a skin condition specifically caused by exposure to dioxins. For this group, the rate of NMISC was more than 80 percent.

Call for More Research on Risks and Treatment

The rate of malignant melanoma, the most serious type of skin cancer, was similar to that expected in men of similar age. However, the article includes two case reports of unusually aggressive NMISCwith numerous recurrences requiring multiple surgeriesoccurring in TCDD-exposed veterans.

Exposure to Agent Orange and TCDD has been linked to a wide range of health problems, including many different cancers. However, its association with the basal cell carcinoma and squamous cell carcinomathe two most common types of skin cancerhas been unclear.

Cases of "aggressive and diffuse" non-melanoma skin cancers in TCDD-exposed veterans were first reported in plastic surgery journals in the mid-1980s. Dr. Clemens and colleagues initiated their study after observing similar patients in their clinic over the last few years. The researchers emphasize that their study has some important limitationsincluding the lack of detailed information on TCDD exposure and the absence of a comparison group of Vietnam-era veterans not exposed to Agent Orange.

Nevertheless, the results strengthen the previously reported association between TCDD exposure and the development of NMISC, even many years after exposure. Certain groups appear to be at particularly high risk, including veterans actively involved in spraying Agent Orange, those with chloracne, and those with lighter skin types. Dr. Clemens and coauthors write, "Further studies are warranted to determine the relative risk within this patient population and to determine appropriate management strategies so that veterans may receive the care they earned in service."


'/>"/>

Contact: Connie Hughes
Connie.Hughes@wolterskluwer.com
646-674-6348
Wolters Kluwer Health
Source:Eurekalert

Related medicine news :

1. Pig stomach mucins are effective as anti-viral agents for consumer products
2. Imaging agents predict breast cancer response to endocrine therapy
3. Difficult to diagnose cases of infectious endocarditis solved with SPECT/CT imaging agent
4. New substances 15,000 times more effective in destroying chemical warfare agents
5. Therapy combining exercise and neuroprotective agent shows promise for stroke victims
6. Scientists ID Cancer-Causing Agent in Smokeless Tobacco
7. Mayo Clinic gets FDA approval for new imaging agent for recurrent prostate cancer
8. Travel Services (MyTSOnline) in Valencia Teams Up With Vendors to Become the Number One Travel Agent in the Santa Clarita Valley
9. Rilpivirine for HIV: Added benefit for single agent proven
10. Updated Clinical Results Show Experimental Agent Ibrutinib as Highly Active in CLL Patients
11. Investigational agent targets gene signaling pathways to improve response for patients with CLL
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... ... ... Rod Burkett, CEO of Gardant Management Solutions, was recently featured in The ... forefront of Gardant since it was founded in 1999. His drive and inquisitive nature ... than 40 new senior living communities. With his leadership, Gardant has grown to be ...
(Date:4/24/2017)... , ... April 24, 2017 , ... Come to PAINWeekEnd ... 4200 Jim Walter Blvd, for an educational and exciting 2-day program. , An ... staff hearing this before they approach patients” about the course entitled Ain't Misbehavin': Decreasing ...
(Date:4/24/2017)... ... April 24, 2017 , ... A ... over the last decade, student well-being has seriously declined. "When disenfranchised youth from ... education, join the Islamic State to turn the historic multi-ethnic and multi-religious powerhouses ...
(Date:4/24/2017)... ... April 24, 2017 , ... “The Saint with Trin, and Omega Station”: ... Station” is the creation of published author, Chris Jackson. Chris Jackson grew up ... in the Dallas Independent School District teaching English. He is heavily involved in the ...
(Date:4/24/2017)... ... April 24, 2017 , ... ... wear distributors and International relief organizations across the globe to provide effective protection ... lifestyle and work wear collections via insectshield.com . In the wake of ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... , April 20, 2017 Research and ... Market Size, Market Share, Application Analysis, Regional Outlook, Growth Trends, ... report to their offering. ... The global pharmacogenomics market was valued at US$ 7,167.6 Mn ... by 2024, expanding at a CAGR of 5.6% from 2016 ...
(Date:4/20/2017)... Research and Markets has announced the addition of ... By Service (Manufacturing, Research), By Country, (Brazil, Mexico, Colombia, Argentina, ... to their offering. ... The Latin American pharmaceutical contract manufacturing services market is anticipated ... drug registration cost in Latin American countries and continuous economic ...
(Date:4/19/2017)... , April 19, 2017 The Mobile X-Ray ... showcase a healthy CAGR during the forecast period ... in the global digital mobile X-Ray devices market, which is ... in 2017, expanding at a CAGR of 7% over the ... $ opportunity of more than US$ 100 Mn in 2017 ...
Breaking Medicine Technology: