Navigation Links
Agent Orange exposure linked to life-threatening prostate cancer
Date:5/13/2013

A new analysis has found a link between exposure to Agent Orange and lethal forms of prostate cancer among US Veterans. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the findings suggest that Agent Orange exposure history should be incorporated into prostate screening decisions for Veterans.

The herbicide Agent Orange was heavily used during the Vietnam War era and was often contaminated with dioxin, a dangerous toxin and potential carcinogen. Prior research suggests that exposure to Agent Orange may increase men's risk of developing prostate cancer, but it is unclear whether it specifically increases their risk of developing lethal forms of the disease. "This is an important distinction as the majority of prostate cancer cases are non-lethal and thus do not necessarily require detection or therapy. Having a means of specifically detecting life-threatening cancer would improve the effectiveness of screening and treatment of prostate cancer," said Mark Garzotto, MD, of the Portland Veterans Administration Medical Center and Oregon Health & Science University.

To look for a link between Agent Orange exposure and life-threatening, or high-grade, prostate cancer, Nathan Ansbaugh, MPH, designed and conducted analyses on a group of 2,720 US Veterans who were referred by multiple providers for initial prostate biopsy. Biopsy results and clinical information were compiled for analysis by principal investigator Dr. Garzotto.

Prostate cancer was diagnosed in 896 (32.9 percent) of the Veterans; 459 (16.9 percent) had high-grade disease. Agent Orange exposure was linked with a 52 percent increase in overall risk of prostate cancer detection by biopsy. Exposure to the herbicide did not confer an increase in risk of low-grade prostate cancer, but it was linked with a 75 percent increase in risk of high-grade prostate cancer. In addition, Agent Orange exposure was associated with more than a two-fold increase in the highest-grade, most lethal cancers.

This study indicates that determining men's Agent Orange exposure status is a readily identifiable means of improving prostate cancer screening for US Veterans, allowing for earlier detection and treatment of lethal cases and potentially prolonging survival and improving quality of life. "It also should raise awareness about potential harms of chemical contaminants in biologic agents used in warfare and the risks associated with waste handling and other chemical processes that generate dioxin or dioxin-related compounds," said Dr. Garzotto.


'/>"/>

Contact: Amy Molnar
sciencenewsroom@wiley.com
Wiley
Source:Eurekalert

Related medicine news :

1. Pig stomach mucins are effective as anti-viral agents for consumer products
2. Imaging agents predict breast cancer response to endocrine therapy
3. Difficult to diagnose cases of infectious endocarditis solved with SPECT/CT imaging agent
4. New substances 15,000 times more effective in destroying chemical warfare agents
5. Therapy combining exercise and neuroprotective agent shows promise for stroke victims
6. Scientists ID Cancer-Causing Agent in Smokeless Tobacco
7. Mayo Clinic gets FDA approval for new imaging agent for recurrent prostate cancer
8. Travel Services (MyTSOnline) in Valencia Teams Up With Vendors to Become the Number One Travel Agent in the Santa Clarita Valley
9. Rilpivirine for HIV: Added benefit for single agent proven
10. Updated Clinical Results Show Experimental Agent Ibrutinib as Highly Active in CLL Patients
11. Investigational agent targets gene signaling pathways to improve response for patients with CLL
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2017)... ... May 22, 2017 , ... WeightZone Factor ... to empower WeightZone Factor members to track their exercise patterns, monitor behavioral changes, ... education, all on their mobile phones. It also provides social networks for members ...
(Date:5/21/2017)... , ... May 19, 2017 , ... ... to announce the appointment of James (Jim) Vertino as Chief Information Officer (CIO). ... proven, transformational leader who drives innovation and business performance. He defines strategic roadmaps ...
(Date:5/21/2017)... WINTER PARK, FL (PRWEB) , ... May 20, 2017 , ... ... now sell it, find it, review it, and share its attributes like never before. ... online dispensary directory to connect cannabis enthusiasts to stores, strains, products – and for ...
(Date:5/21/2017)... ... May 21, 2017 , ... For more than 20 years United Cutlery ... of knives and swords, from functional to fantasy. United Cutlery has always been “Stronger. ... designs that defy tradition. , Offering a range of weapons and tools built for ...
(Date:5/19/2017)... ... ... In a continuous effort to raise awareness of autism and common toxins found ... natural and organic latex mattresses, has announced that they will donate $1 to the ... recent viral Facebook video receives, up to $10,000.00. , The luxury online ...
Breaking Medicine News(10 mins):
(Date:5/4/2017)... , May 4, 2017  A new tight-tolerance ... and other highly-engineered materials, is being launched by ... has been developed in recent years to service ... and surgical applications. More expensive materials such as ... microextrusion tubing due to their ability to consistently ...
(Date:5/3/2017)... 2017  Getinge, a leading global provider of ... and cost efficiency within healthcare and life sciences, ... practice demonstrating that intra-aortic balloon counterpulsation (IABC) appears ... patients. The single-center, retrospective, observational study showed that ... ® 50cc intra-aortic balloon (IAB) in contemporary ...
(Date:5/2/2017)... , May 2, 2017  CIVCO Radiotherapy, the ... solutions, announced today that Nat Geissel ... CIVCO since 2012 and has served as vice ... vice president and general manager, and most recently, ... "I am extremely proud of what CIVCO Radiotherapy ...
Breaking Medicine Technology: