Navigation Links
Agent Orange exposure linked to life-threatening prostate cancer
Date:5/13/2013

A new analysis has found a link between exposure to Agent Orange and lethal forms of prostate cancer among US Veterans. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the findings suggest that Agent Orange exposure history should be incorporated into prostate screening decisions for Veterans.

The herbicide Agent Orange was heavily used during the Vietnam War era and was often contaminated with dioxin, a dangerous toxin and potential carcinogen. Prior research suggests that exposure to Agent Orange may increase men's risk of developing prostate cancer, but it is unclear whether it specifically increases their risk of developing lethal forms of the disease. "This is an important distinction as the majority of prostate cancer cases are non-lethal and thus do not necessarily require detection or therapy. Having a means of specifically detecting life-threatening cancer would improve the effectiveness of screening and treatment of prostate cancer," said Mark Garzotto, MD, of the Portland Veterans Administration Medical Center and Oregon Health & Science University.

To look for a link between Agent Orange exposure and life-threatening, or high-grade, prostate cancer, Nathan Ansbaugh, MPH, designed and conducted analyses on a group of 2,720 US Veterans who were referred by multiple providers for initial prostate biopsy. Biopsy results and clinical information were compiled for analysis by principal investigator Dr. Garzotto.

Prostate cancer was diagnosed in 896 (32.9 percent) of the Veterans; 459 (16.9 percent) had high-grade disease. Agent Orange exposure was linked with a 52 percent increase in overall risk of prostate cancer detection by biopsy. Exposure to the herbicide did not confer an increase in risk of low-grade prostate cancer, but it was linked with a 75 percent increase in risk of high-grade prostate cancer. In addition, Agent Orange exposure was associated with more than a two-fold increase in the highest-grade, most lethal cancers.

This study indicates that determining men's Agent Orange exposure status is a readily identifiable means of improving prostate cancer screening for US Veterans, allowing for earlier detection and treatment of lethal cases and potentially prolonging survival and improving quality of life. "It also should raise awareness about potential harms of chemical contaminants in biologic agents used in warfare and the risks associated with waste handling and other chemical processes that generate dioxin or dioxin-related compounds," said Dr. Garzotto.


'/>"/>

Contact: Amy Molnar
sciencenewsroom@wiley.com
Wiley
Source:Eurekalert

Related medicine news :

1. Pig stomach mucins are effective as anti-viral agents for consumer products
2. Imaging agents predict breast cancer response to endocrine therapy
3. Difficult to diagnose cases of infectious endocarditis solved with SPECT/CT imaging agent
4. New substances 15,000 times more effective in destroying chemical warfare agents
5. Therapy combining exercise and neuroprotective agent shows promise for stroke victims
6. Scientists ID Cancer-Causing Agent in Smokeless Tobacco
7. Mayo Clinic gets FDA approval for new imaging agent for recurrent prostate cancer
8. Travel Services (MyTSOnline) in Valencia Teams Up With Vendors to Become the Number One Travel Agent in the Santa Clarita Valley
9. Rilpivirine for HIV: Added benefit for single agent proven
10. Updated Clinical Results Show Experimental Agent Ibrutinib as Highly Active in CLL Patients
11. Investigational agent targets gene signaling pathways to improve response for patients with CLL
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... San Francisco, California (PRWEB) , ... December 08, 2016 , ... ... health coaches, has raised an $18M Series B led by Canvas Ventures . ... use the capital to scale its mobile platform to serve more consumers who are ...
(Date:12/8/2016)... , ... December 08, 2016 , ... ... financial planning services from offices headquartered in Hamilton County, is embarking on a ... , LuvFurMutts specializes in finding new homes for orphaned or neglected senior dogs ...
(Date:12/8/2016)... ... December 08, 2016 , ... Peter Zipp Insurance, ... and around the greater Phoenix metropolitan region, is announcing a charity event to ... of the Homeless Youth Connection is to promote community awareness of the ongoing ...
(Date:12/8/2016)... ... December 08, 2016 , ... The Compretta Insurance Agency, ... residential clients in and around the Hancock County area, is announcing the launch of ... Food Pantry. , The Hancock County Food Pantry has worked for more than 30 ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... to families and business owners in and around central Kansas, is joining the ... at-risk youth in the region. , Headquartered in Wichita, Youth Horizons works to ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... Dec. 7, 2016 A new investigational drug originally ... clinical trials in search of the world,s first treatment to ... of research findings today in the journal Science ... be a watershed moment for millions of people living with ... of Van Andel Research Institute,s Center for ...
(Date:12/7/2016)... -- REPORT OBJECTIVES The report "SPF ... on a market segment, based on geography. Market ... the report. The primary objectives of this report ... through detailed segmentation, 2) market size and forecasts, ... market situation, trends, 3) detailed analysis of current ...
(Date:12/7/2016)... , Dec. 7, 2016  Northwest Biotherapeutics (Nasdaq: ... "Company"), a biotechnology company developing DCVax® personalized immune ... the Nasdaq Staff has not accepted the Company,s ... Rules previously reported, and the Company has notified ... Company,s common stock from listing on Nasdaq.  Upon ...
Breaking Medicine Technology: