Navigation Links
Agent Orange exposure linked to Graves' disease in Vietnam veterans, UB study finds
Date:6/28/2010

BUFFALO, N.Y. -- Vietnam War-era veterans exposed to Agent Orange appear to have significantly more Graves' disease, a thyroid disorder, than veterans with no exposure, a new study by endocrinologists at the University at Buffalo has shown.

Ajay Varanasi, MD, an endocrinology fellow in the UB Department of Medicine and first author on the study, garnered first prize in the oral presentation category for this research at the American Association of Clinical Endocrinologists annual meeting held in Boston in April.

"Our findings show that Vietnam veterans who came in contact with Agent Orange are more likely to develop Graves' disease than those who avoided exposure," says Varanasi.

"The autoimmune disorder was three times more prevalent among veterans who encountered the dioxin-containing chemical. We also looked at other thyroid diagnoses, but we didn't find any significant differences in thyroid cancer or nodules."

Agent Orange is a defoliant that was used in Vietnam to destroy crops and reduce jungle foliage that could shelter enemy combatants. The herbicide contains dioxin, which has chemical properties similar to the thyroid hormones.

Graves' disease is an autoimmune disease associated with overactivity of the thyroid gland. This gland releases the hormones thyroxine (T4) and triiodothyronine (T3), which control body metabolism and are critical for regulating mood, weight, and mental and physical energy levels.

Varanasi and colleagues assessed the prevalence of major thyroid diagnoses in the Veterans Administration electronic medical record database for upstate New York veterans born between 1925 and 1953, the age group that would have been eligible for military service during the Vietnam era. They conducted the research at the Buffalo VA Medical Center.

They compared the frequency of diagnoses of thyroid cancer, nodules, hypothyroidism and Graves' disease in veterans who identified themselves as being exposed to Agent Orange (23,939) or not exposed to Agent Orange (200,109).

"Analyzing data on thyroid conditions, we found no difference in the prevalence of thyroid nodules or cancers between the exposed and non-exposed groups," says Varanasi. "Graves' disease, however, was three times more prevalent in the exposed group.

"Interestingly, hypothyroidism [lower than normal thyroid] was less common in the exposed group."

Varanasi says that in view of the known effects of dioxin on the immune system, further research should be conducted on the increased prevalence of Graves' disease in Vietnam veterans. His research group is planning to continue this investigation either in vitro or in animal models.


'/>"/>

Contact: Lois Baker
ljbaker@buffalo.edu
716-645-4606
University at Buffalo
Source:Eurekalert

Related medicine news :

1. New Research Uncovers Elusive Target of Antifungal Agent
2. Compound enhances cancer-killing properties of agent in trials
3. Shark cartilage shows no benefit as a therapeutic agent for lung cancer
4. Mayo-led research team develop agents that keep insulin working longer
5. Health Insurance Agents Work with Zane Benefits to Offer New Solutions amid Health Care Reform
6. New agent chokes off energy supply, kills cancer cells
7. Targeted agent blocked growth of deadly brain cancer in preclinical studies
8. Scott & White Healthcare researchers studying investigational agent that targets breast cancer
9. Overcoming tumor resistance to anti-cancer agent TRAIL
10. Professional Insurance Agents Name Rep. Charlie Melancon 2010 Legislator of the Year
11. Long Term Care Insurance Leader Seeks 320 New Agents in 2010, Following Strong 2009 Growth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2017)... ... May 24, 2017 , ... Dr. Manju R. Kejriwal, ... ClearCorrect orthodontics, with or without a referral. Dr. Kejriwal understands the emotional and ... convenient, clear braces in Cincinnati, OH. Patients no longer need to feel the esthetic ...
(Date:5/24/2017)... ... May 24, 2017 , ... Myers Jackson is well known for ... to sell luxury homes anywhere on the planet. The luxury home market is alive ... to Houston city-scapes. A quick search of “11 Spyglass Hill Auction will enlighten you ...
(Date:5/24/2017)... ... May 24, 2017 , ... Medic CE , ... Surprising Truth about Pediatric Septic Shock” hosted by the Journal of Emergency Medical Services ... p.m. Eastern time, will be presented by Captain Rommie Duckworth, LP, a career fire ...
(Date:5/24/2017)... ... May 24, 2017 , ... ... pediatric dentistry options for its patients on Long Island, New York. , ... well being, and is one of the biggest trends in dentistry today. ...
(Date:5/24/2017)... ... May 24, 2017 , ... ... ingredient solutions for the food and beverage industry offers Citri-Fi®, a natural citrus ... during the purchasing decision process. As a result, labels need to deliver simple, ...
Breaking Medicine News(10 mins):
(Date:5/9/2017)... 2017  Semler Scientific, Inc. (OTCQB: SMLR), an ... improve the clinical effectiveness and efficiency of healthcare ... quarter ended March 31, 2017. ... to identify when preventive care options are appropriate, ... heart attacks or strokes occur," said Doug ...
(Date:5/6/2017)... SKANEATELES FALLS, N.Y. , May 5, 2017 /PRNewswire/ ... expansion that will add approximately 100,000 square feet to ... announced in September 2016 its commitment to bring more ... York , where Welch Allyn has maintained a ... facility will help accommodate these new positions, a large ...
(Date:5/4/2017)... Israel , May 4, 2017  DarioHealth Corp. ... mobile health and big data solutions, today announced that ... A&D Company, and STI Technologies Limited to lower diabetes ... immediately. Through STI,s innoviCares card, which is available throughout ... , DarioHealth customers will be eligible for additional savings ...
Breaking Medicine Technology: