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Age tied to spread of rectal cancer to lymph nodes
Date:10/28/2012

BOSTON, MA (October 28, 2012)Rectal cancer is more likely to spread to the lymph nodes in younger patients, according to new findings that Fox Chase Cancer Center researchers will be presenting on October 29 at the American Society for Radiation Oncology's 54th Annual Meeting. The resultswhich are the first of their kindsuggest that doctors should search for spreading more aggressively in these patients.

Once rectal cancer has spread to the lymph nodes, it is more likely to return to the pelvis following surgery. Administering chemotherapy and radiation before surgery reduces that risk, so before the procedure doctors typically perform a scanultrasound, PET, or MRIto search for signs of cancer in the lymph nodes.

These findings suggest that doctors should hunt for affected lymph nodes more aggressively in younger patients, by perhaps performing multiple scans, says study author Joshua Meyer, MD, attending physician in the Radiation Oncology Department at Fox Chase.

"When doctors have younger patients, they might think twice before being confident rectal cancer has not spread to the lymph nodes," says Meyer. "It makes a lot of sense to be more aggressive in checking for lymph node involvement in people younger than 50."

This is the first study to show that age is associated with the risk that rectal cancer will spread to the lymph nodes, says Meyer. The idea for the project came out of an observation by his collaborator Steven Cohen, MD, chief of gastrointestinal medical oncology at Fox Chase, who noticed a couple of young patients with an early stage of rectal cancer that had unexpectedly spread to the lymph nodes"which is not something one would expect," says Meyer. "Because of that, he said, 'I wonder if the risk of spread is somehow connected to their age.' I said, 'Well, this is something we can test.'"

Indeed, the researchers had access to a massive database of information about cancer patients run by the Nat
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Contact: Diana Quattrone
Diana.Quattrone@fccc.edu
215-728-7784
Fox Chase Cancer Center
Source:Eurekalert

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