Navigation Links
After the human genome project: The human microbiome project
Date:2/28/2013

Bethesda, MDEarth Day may be more than a month away, but another, more personal, ecosystem has been shown to also be worth protectingwithin our bodies are communities of microbes that affect the behavior of human cells hosting them. These communities, called the "microbiome," is so crucial to our health that some consider it to be a complex "second genome." Understanding the interaction of these microbes among one another and their human hosts has the potential to yield insights into numerous diseases and complex human disorders from obesity to susceptibility to infection. In a new report appearing in the March 2013 issue of The FASEB Journal, scientists take an important step toward designing a uniform protocol for microbiome research that ensures proper controls and considerations for variations among people. By doing this, future researchers should be able to better assess how what we ingest, whether drugs or food, affects our bodies.

"While historically pre and probiotics have dominated the microbiome landscape, emerging data from numerous labs as to the impact of dietary interventions and antibiotic exposure will play formative roles in tailoring therapy," said Kjersti M. Aagaard, M.D., Ph.D., from the Department of Obstetrics and Gynecology at Baylor College of Medicine in Houston, Texas. "We may find that the answers to our most common and prevalent health and disease states lies not in manipulating the human genome, but rather, in utilizing subtle shifts in diet and components of the diet, efficacy trials in prophylactic or preventative antibiotic therapies, and care attention to the over prescription of steroids and antibiotics."

Aagaard and colleagues completed comprehensive body site sampling in healthy 18-40 year old adults, creating an unparalleled reference set of microbiome specimens. Researchers then screened 554 individuals to enroll 300 (149 males, 151 females, mean age 26, mean BMI 24, 20.0 percent racial minority and 10.7 percent Hispanic). Scientists obtained specimens from several body sites to evaluate the longitudinal changes in an individual's microbiome by sampling 279 participants twice (mean 212 days after first sampling, range 30-359), and 100 individuals three times (mean 72 days after second sampling, range 30-224). This sampling strategy yielded 11,174 primary specimens, from which 12,479 DNA samples were submitted to four centers for metagenomic sequencing. This clinical design and well-defined reference cohort has laid a baseline foundation for microbiome research.

"Whether it is yogurt, penicillin, or diet soda, each alters the microbial communities that live within us," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "This pioneering study promises to provide their names and numbers, so that we can understand how diet, disease or drugs affect our internal ecosystem."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related medicine news :

1. Diabetes Doesnt Seem to Raise Risks After Knee Replacement
2. femMED Heart Health Can Help Keep Your Heart Healthy for February and After
3. Superbug CRE may endure in patients 1 year after initial infection: Study
4. Mental health-substance use services in hospitals up after parity law, finds new report
5. Most New Mothers Skip Sex for at Least 6 Weeks After Childbirth
6. Small molecules in the blood might gauge radiation effects after exposure
7. US Drug Watchdog Now Urges Any Woman Who had A Out Of The Blue Stroke Or Heart Attack After Using Birth Control Pills Call Yaz, Or Yasmin to Call the Johnson Law Group
8. Codeine Risky for Kids After Certain Surgeries, FDA Says
9. Microbubbles improve myocardial remodelling after infarction
10. US Drug Watchdog Now Urges Families Of Diabetics Who Developed Bladder Cancer After Using The Diabetes Drug Called To Call The Johnson Law Group-For A Legal Review
11. Military Women Exposed to Combat After Childbirth Face Depression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2016)... ... May 05, 2016 , ... The ... is slated to host the 2016 National SACA Leadership Conference on the Portland ... officers and chapter officers to come together and develop skills to be future ...
(Date:5/5/2016)... (PRWEB) , ... May 05, 2016 , ... ... among Pittsburgh-area schoolchildren has found that more than 40 percent of participating fifth-grade ... MD , Director of Allergy and Asthma Clinical Research in the Division of ...
(Date:5/5/2016)... ... 2016 , ... In order to increase comfort, convenience and ... Seattle-based steam bath and sauna manufacturer recently launched amerecConnect™ , a new ... app, developed for both smartphones and personal computers perfectly emulates that of the ...
(Date:5/5/2016)... Ohio (PRWEB) , ... May 05, 2016 , ... United ... Cycle. , Clark brings more than 15 years of experience within the healthcare ... from a successful career as the Director of Patient Financial Services at Spectrum Health. ...
(Date:5/5/2016)... ... 2016 , ... CURE Media Group , the nation’s leading digital and ... Imerman Angels to expand outreach and emotional support for patients of all ... an emotional lifeline to patients and families facing the challenges of cancer diagnosis and ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... May 4, 2016 According to ... entitled "Brain Computer Interface Market - Global Industry Analysis, Size, ... brain computer interface (BCI) market  is expected to reach ... is estimated to expand at a CAGR of 14.9 ... A BCI device provides collaboration between the ...
(Date:5/4/2016)... 4, 2016 According to market research ... Demand Forecast to 2022 - Industry Insights by Slice Type ... and Others)" by P&S Market Research, the global computed ... and it is expected to grow at a CAGR of ... type segment is expected to witness the faster growth, CAGR ...
(Date:5/4/2016)... , May 4, 2016 ... completion of an alternative public offering (APO). This was ... operating company, Valeritas, Inc. and a private placement of ... at $5.00 per share. Under the terms ... 3, 2016, Valeritas Holdings, Inc. will trade on the ...
Breaking Medicine Technology: