Navigation Links
After heart attack, bone marrow stem cells increase blood flow within heart
Date:3/30/2009

Patients treated with their own bone marrow stem cells after a heart attack experienced increased circulation within the heart, a study by Emory University School of Medicine physicians has found.

Principal investigator Arshed Quyyumi, MD, professor of medicine at Emory University School of Medicine, presents the results Monday at the American College of Cardiology conference in Orlando.

"These results show that treatment with a patient's own bone marrow stem cells has the potential to reduce long-term complications after a heart attack," Quyyumi says. "We are encouraged by these results and are planning to conduct a more extensive study."

A severe enough heart attack can lead to remodeling of the heart muscle and increased risk of heart failure and other complications.

Several groups of researchers around the world have reported clinical trials in which cells from the bone marrow are used to try to restore the heart's pumping power, with mixed results. This study was one of the first to use a preparation of bone marrow cells enriched for endothelial progenitor cells, which are thought to replenish the linings of blood vessels. Emory University, Vanderbilt University, The Lindner Research Center, Cincinnati, and Texas Heart Center in Houston participated.

In the clinical trial, which began in June 2006, 31 patients were treated by angioplasty and stent placement after a heart attack. Within a week after their heart attacks, 16 of the patients had bone marrow cells infused into the coronary artery where a blockage caused the heart attack.

Members of this group received three different amounts of magnetically sorted bone marrow cells (5, 10 and 15 million cells). The control group received standard medication only. No significant adverse events were reported. The patients will be followed for up to five years.

Doctors assessed healing and remodeling of patients' hearts with nuclear (single photon emission computed tomography) stress testing, magnetic resonance imaging, and echocardiography three months and six months later. Patients receiving higher doses of cells had greater improvement in blood flow within the heart than those patients treated with lower doses or those receiving medication alone.

"This is critical information for future study design the more cells a patient receives, the more beneficial effect we see in the heart," Quyyumi says.

Higher doses of cells also appeared to provide some benefit in cardiac function, determined by measuring the percentage of blood pumped out with each heartbeat and tissue death due to loss of adequate blood supply, but these results were not considered significant statistically.


'/>"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University
Source:Eurekalert

Related medicine news :

1. Microsurgery May Cut Swelling After Breast Cancer Treatment
2. Getting Social Security Disability Benefits Isn't Simple, Even After Approval
3. New Hope & Resilience After Destruction and Killings in Gaza, Israel
4. Lab-grown nerves promote nerve regeneration after injury
5. Washington DC-area IVF Specialist Suheil Muasher, MD Addresses Fears of Infertility Treatments after Octuplet Mom News
6. Any Exercise Good After a Heart Attack
7. Weighing the options after life-altering stroke
8. Docs More Supportive of Stem Cell Research Funding Than Consumers After Viewing Presidents Speech
9. Florida Plastic Surgeon Comments on the Safety of Silicone Breast Implants, 2 Years after FDA Approval
10. Keryx Biopharmaceuticals, Inc. Requests an Appeal Hearing After Receiving Notice of Delisting From Nasdaq
11. NxStage Reports Sustained Reduction in Clinical Depressive Symptoms for Daily Home Hemodialysis Patients After One Year
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2017)... ... 2017 , ... If you are thinking of a visit to San Francisco , fall ... the perfect time to visit. , Business Architecture Associates is pleased to offer 5 days ... as a 4-½ day package for individuals, and as 4-½ day corporate package for up ...
(Date:5/24/2017)... ... May 24, 2017 , ... Technique, technique, technique – with a ... lifting weights for strength training and exercise or simply lifting heavy objects, advises Dr. ... position is everything,” Dr. Chang says. “Improper technique in lifting anything heavy or an ...
(Date:5/23/2017)... ... May 23, 2017 , ... ... and medical device sectors, today announced the winners of its 3rd Annual ELITE ... the most influential people in the healthcare industry today. , Out of more ...
(Date:5/23/2017)... Newport Beach, CA (PRWEB) , ... May 23, 2017 , ... ... Capital Partners was honored to serve earlier this month as a Guest Speaker and ... by the British Royal Family and Common Purpose. , Walter Schindler ...
(Date:5/23/2017)... ... May 23, 2017 , ... ... chat as a standard feature on its secure clinical communication platform. The platform ... to video depending on the type and urgency of a situation. , ...
Breaking Medicine News(10 mins):
(Date:5/6/2017)... May 5, 2017  Hill-Rom Holdings, Inc. (NYSE: HRC), ... 100,000 square feet to its Welch Allyn campus. ... commitment to bring more than 100 new jobs to ... Allyn has maintained a significant presence for more than ... new positions, a large portion of which will be ...
(Date:5/4/2017)... SAN DIEGO , May 4, 2017  The ... Clinical and Scientific Meeting— OBP Medical , a leading ... announced the launch of a new extra-small size and ... ER-SPEC vaginal specula. Already available in small, ... sizes makes OBP Medical,s line of single-use lighted specula ...
(Date:5/3/2017)... 3, 2017 A Catheterization Laboratory is ... healthcare facility. Commonly referred to as cath lab, ... diagnostic imaging technology to give physicians visual access ... these spaces, a team of physicians perform life-saving ... coronary intervention, congenital heart defect closure, stenotic heart ...
Breaking Medicine Technology: