Navigation Links
After 100 years, understanding the electrical role of dendritic spines
Date:12/5/2012

lbous spine head at the end of a thin tube, or neck. Each spine head contains one or more synapses and is located in very close proximity to an axon coming from another neuron.

Scientists have gained insight into the chemical properties of dendritic spines: receptors on their surface are known to respond to a number of neurotransmitters, such as glutamate and glycine, released by other neurons. But because of the spines' incredibly small size roughly 1/100 the diameter of a human hair their electrical properties have been harder to study

In this study, researchers at the HHMI Janelia Farm Research Campus used three experimental techniques to assess the electrical properties of dendritic spines in rats' hippocampi, a part of the brain that plays an important role in memory and spatial navigation. First, the researchers used two miniature electrodes to administer current and measure its voltage response at different sites throughout the dendrites.

They also used a technique called "glutamate uncaging," a process that involves releasing glutamate, an excitatory neurotransmitter, to evoke electrical responses from specific synapses, as if the synapse had just received a signal from a neighboring neuron. A third process utilized a calcium-sensitive dye calcium is a chemical indicator of a synaptic event injected into the neuron to provide an optical representation of voltage changes within the spine.

At Northwestern, researchers used computational models of real neurons reconstructed from the same type of rat neurons to build a 3D representation of the neuron with accurate information about each dendrites' placement, diameter, and electrical properties. The computer simulations, in concert with the experiments, indicated that spines' electrical resistance is consistent throughout the dendrites, regardless of where on the dendritic tree they are located.

While much research is still needed to gain a full understanding of
'/>"/>

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Mayo Clinic: Less invasive surgery detects residual breast cancer in lymph nodes after chemotherapy
2. Rejected hearts now viable for transplantation after stress echo
3. Smoking may worsen hangover after heavy drinking
4. The US Drug Watchdog Now Urges Women Who Suffered A Heart Attack Or Stroke After Using Yaz Yasmin Birth Control Pills To Contact The Johnson Law Group Immediately
5. U.S. Kids Might Not Be Over-Medicated After All
6. Experts urge rapid evaluation for swallowing and voice problems after brain surgery
7. Certain Arthritis Patients Fare Worse After Joint Replacement: Study
8. Complications challenge rheumatoid arthritis patients after joint replacement surgery
9. U.S. Kids Getting Enough Sleep After All: Survey
10. Imaging shows some brains compensate after traumatic injury
11. Researchers find evidence that brain compensates after traumatic injury
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
After 100 years, understanding the electrical role of dendritic spines
(Date:5/6/2015)... Hope For The Warriors® and American ... at the New York Athletic Club on April 21, ... The Warriors®, a national nonprofit dedicated to restoring a ... hope for our service members and our military families. ... local and nationwide military families. The Barry Fixler Foundation/Semper ...
(Date:5/6/2015)... Wethersfield, Conn. (PRWEB) May 06, 2015 ... company in Wethersfield, Conn., has hired healthcare executive ... vice president. Olson will lead Qualidigm’s growing ... further Qualidigm’s mission to improve the quality, safety, ... Olson comes to Qualidigm from Interim HealthCare of ...
(Date:5/6/2015)... (PRWEB) May 06, 2015 Doctors who ... reported what they are calling “unprecedented” tumor control in ... on the new research. Click here to read ... pembrolizumab to 25 mesothelioma patients between March and December ... in April. , “Pembrolizumab… provides robust antitumor activity in ...
(Date:5/6/2015)... Stout Industries is owned and operated ... Austin, Texas fire departments. Stout Industries recently developed Fire-ground ... components to these fire safety devices. The departure lights ... is turned on. They light the area within 50 feet ... on the roof, preventing leg and ankle injuries. In ...
(Date:5/6/2015)... 2015 Spiking drug prices are taking large ... survey by The Senior Citizens League (TSCL). ... co-pays and co-insurance costs than expected in 2014 according to ... cost spikes may be tough for many beneficiaries to figure ... prices are commonly associated with brand and newer specialty drugs, ...
Breaking Medicine News(10 mins):Health News:4th Annual Casino Night Draws Support for Military Families in New York City Region 2Health News:Innovative Healthcare Executive Ann Olson Joins Qualidigm as Principal and Vice President 2Health News:Innovative Healthcare Executive Ann Olson Joins Qualidigm as Principal and Vice President 3Health News:Researchers Say “Unprecedented” Mesothelioma Response Possible with Skin Cancer Drug, According to Surviving Mesothelioma 2Health News:Kickstarter for FIRE Lights, the New Fire Safety Devices 2Health News:New Survey By The Senior Citizens League Reveals 61% Had Higher Than Expected Medicare Part D Costs In 2014 2Health News:New Survey By The Senior Citizens League Reveals 61% Had Higher Than Expected Medicare Part D Costs In 2014 3
... of an effort to make high-precision particle cancer therapy ... Department of Energy,s (DOE) Brookhaven National Laboratory has developed ... beams. Brookhaven Science Associates, the company that manages the ... patent on the design, which is now available for ...
... A new study provides doctors with guidelines on when ... patients. , International clinical guidelines on the ... countries. For a serious condition like osteoporosis, affecting millions, ... Tuan Nguyen and Dr Nguyen Nguyen from the Garvan ...
... $5 Million Effort Aimed at Building Public Health Workforce ... The University of California, Berkeley , announced today the ... to meet the increasing need for highly educated public health ... established in 2004 by Kaiser Permanente at the East Bay ...
... of diabetes treatments, local gyms and fresh food among ... implementing healthy habits to take control of their diabetes ... Diabetes (TCOYD), a not-for-profit organization dedicated to informing and ... their own health care, announced findings today from a ...
... is a Leader in Supporting the CommunityPORTLAND, Ore., May ... men and women, is actively involved in keeping Portland ... to raise money for charitable auctions, making cash donations ... food drives for women,s and children,s shelters, partnering with ...
... Nationwide locations open doors to professionals and families caring ... May 12 Sunrise Senior Living (NYSE: ... of HBO,s The Alzheimer,s Project to encourage ... the numerous issues surrounding it. Locate a local ...
Cached Medicine News:Health News:Compact cancer-therapy particle-delivery system patented 2Health News:When to get your bone density measured -- that is the question 2Health News:UC Berkeley Launches Kaiser Permanente Community Health Scholars Program 2Health News:UC Berkeley Launches Kaiser Permanente Community Health Scholars Program 3Health News:Indianapolis Residents View Economic Challenges as Significant Barrier to Properly Managing Type 2 Diabetes 2Health News:Indianapolis Residents View Economic Challenges as Significant Barrier to Properly Managing Type 2 Diabetes 3Health News:Indianapolis Residents View Economic Challenges as Significant Barrier to Properly Managing Type 2 Diabetes 4Health News:Bishops Barbershop - Keeping Portland a Great Place to Live 2Health News:Sunrise Senior Living Communities to Show HBO's The Alzheimer's Project 2Health News:Sunrise Senior Living Communities to Show HBO's The Alzheimer's Project 3
(Date:5/5/2015)... 5, 2015  In line with CBME China,s 15 ... community with a charity program to create awareness, draw ... CBME China team is coordinating a donation ... manufacturers, brand owners and distributors. All donated products will ... Proceeds from the sale will be used to support ...
(Date:5/5/2015)... 2015  CorMedix Inc. (NYSE MKT: CRMD), a biopharmaceutical ... the treatment of infectious diseases, announced that it will ... Randy Milby , Chief Executive Officer of CorMedix, ... 8 at 9:00 a.m. EDT.  In ... 1-877-407-8031 (U.S.), 1-201-689-8031 (outside the U.S.). All participants who ...
(Date:5/5/2015)... 2015   Temptime Corporation , the world,s leading ... announced today that its board of directors has promoted ... executive officer.  Mr. Van den Hooff , 56, ... "Renaat deeply values Temptime,s mission of improving global ... Temptime,s products and services to organizations that are saving ...
Breaking Medicine Technology:CBME China Launches Charity Program to Support Children with Autism 2CorMedix, Inc. to Report First Quarter Financial Results on May 8, 2015 2Temptime President Renaat Van den Hooff Promoted to CEO 2
... Conn., Feb. 28, 2012 /PRNewswire-iReach/ --  Silver ... New Canaan, CT, announces the opening of the Chronic ... for patients with pain who have become addicted to ... American Pain Society, is the Medical Director. ...
... Crothall Healthcare announced the name change of its ... Solutions (CES). The new name emphasizes Crothall,s intent to ... of healthcare technology rather than the traditional "fix it" ... CES division will continue to focus on safety, risk ...
Cached Medicine Technology:Silver Hill Hospital, Nationally Recognized Psychiatric Institution Opens Groundbreaking Chronic Pain and Addiction Treatment Center 2Silver Hill Hospital, Nationally Recognized Psychiatric Institution Opens Groundbreaking Chronic Pain and Addiction Treatment Center 3Crothall Healthcare Introduces Clinical Equipment Solutions Division 2
Drugs of Abuse (DoA) Array is used for in-vitro diagnostic tests for the qualitative determination of the parent molecule and metabolites of drugs in human urine....
For use with catalog #0540....
Lupus Anticoagulant-Sensitive APTT Reagent.Cephalin with particulate activator (silica), freeze-dried....
Antigenic Total Protein S, ELISA Method...
Medicine Products: