Navigation Links
African Americans with blood cancer do not live as long as caucasians, despite equal care
Date:7/7/2013

A new analysis has found that among patients with chronic lymphocytic leukemia, African Americans more commonly present with advanced disease, and they tend to have shorter survival times than Caucasians despite receiving the same care. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the results suggest that biological factors may account for some racial disparities in cancer survival.

Among cancer patients, minorities tend to have a worse prognosis than Caucasians for reasons that are unclear. In African American patients, lower socioeconomic status and limited access to high-quality care often can play a role, but some researchers propose that certain cancers can behave more aggressively in minority individuals, which also can lead to worse outcomes.

Because chronic lymphocytic leukemia (CLL), a type of blood cancer, is rare in African Americans, investigators from The University of Texas MD Anderson Cancer Center in Houston and the Duke University Medical Center in Durham led a study that combined the two centers' experiences with African American and Caucasian patients. Their analysis included 84 African American patients and 1,571 non-black patients referred to the two centers. All patients, regardless of race, had access to healthcare services and received the same treatments. "We sought to isolate race as a prognostic factor from other known demographic and clinical prognostic parameters in CLL," explained Dr. Falchi.

The investigators found that while the time from diagnosis (made either incidentally or because of clinical symptoms) to referral was shorter for African Americans than Caucasian patients, African Americans were more likely to have CLL that was more advanced at the time of referral. Also, although African Americans responded as well to first-line therapy as Caucasian patients, their cancer progressed more rapidly and their survival was shorter. The inferior survival of African American patients persisted when patients were grouped according to factors related to the severity of their disease.

"These findings suggest that while inducing similarly high response rates, standard treatments do not overcome racial differences in outcome among patients with CLL," said Dr. Ferrajoli. She added that a number of questions remain unanswered. For example, do distinct biologic characteristics of African American patients with CLL account for the disparities seen in this study? And will these findings hold in the general population, where the impact of socioeconomic status may be more varied?

In an accompanying editorial, Christopher Flowers, MD, of Emory University in Atlanta, and Barbara Pro, MD, of Thomas Jefferson University in Philadelphia, noted that to adequately study disparities in leukemia, investigators will need to collect specimens and clinical data from patients to examine the potential impact of molecular and biologic markers. "Future studies in CLL can use this work as a cornerstone for investigating racial disparities in this disease," they wrote.


'/>"/>

Contact: Ben Norman
sciencenewsroom@wiley.com
44-012-437-70375
Wiley
Source:Eurekalert

Related medicine news :

1. Normal triglyceride levels in people of African descent may hinder diagnosis of metabolic syndrome
2. Can weight loss help African-American breast cancer survivors?
3. Equal access to care helps close survival gap for young African-American cancer patients
4. Systemic sclerosis complications more severe in African Americans than Caucasians
5. Genetic marker may predict smoking quantity in African Americans
6. WSU study finds overwhelming evidence of hidden heart disease in hypertensive African-Americans
7. Nevirapine-based treatment is effective in African women, but not optimal
8. Study finds socioeconomic status linked to weight gain and risk of obesity in African-American women
9. Stanford researchers discover the African cichlids noisy courtship ritual
10. Johns Hopkins African bioethics program receives 5-year continuation grant from NIH
11. Tobacco use more prevalent among African-American adolescents living in public housing communities
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2017)... ... ... account following a man who went on to support his country and serve the Lord. ... Haven, Florida and at the age of 5, his family moved to Pensacola Florida. In ... and got married right out of boot camp. , He and his wife raised ...
(Date:1/20/2017)... , ... January 20, 2017 , ... “Journey to Christmas:” a beautiful and enchanting tale ... published author, Kimberly Cordoves, a mother of three in Oklahoma City, and a devoted woman ... of writing a book has been in the back of my mind for years, but ...
(Date:1/19/2017)... ... January 20, 2017 , ... Today, the Centers for Medicare & ... of CMS’s Alternative Payment Models (APMs) in 2017. Clinicians who participate in APMs are ... an important part of the Administration’s effort to build a system that delivers better ...
(Date:1/19/2017)... ... ... here, many people will have to clear snow with snow blowers or shovels from driveways ... can be dangerous when used incorrectly. That’s why Amica Insurance is sharing the ... blowers:, , When removing wet snow or debris from the blower, ...
(Date:1/19/2017)... ... January 19, 2017 , ... Remote Medical Technologies (RMT), ... transportable capabilities with their iMedHD2™ Portable Teleultrasound System. Compatible with ... that delivers HD, dynamic, streaming ultrasound images and video to one or more ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... -- Report Details ... Alzheimer,s Disease Therapeutics and Diagnostics ... new study reveals trends, R&D progress, and predicted revenues ... Alzheimer,s disease therapeutics and diagnostics market. Our new report ... How is the Alzheimer,s disease therapeutics and diagnostics market ...
(Date:1/19/2017)... 19, 2017  Stealth BioTherapeutics Inc. ( Stealth ), ... dysfunction, today announced new additions to its senior leadership ... Medical Officer, and Daniel Geffken as interim ... Jim Carr , Pharm.D. has been promoted to Chief ... to welcome Doug and Daniel to our management team, ...
(Date:1/19/2017)... SUNNYVALE, Calif. , Jan. 19, 2017 ... that its CyberKnife® and TomoTherapy® Systems continue to set ... systems received the highest composite overall user satisfaction rating ... to the Q4 2016 MD Buyline Market Intelligence Briefing™. ... achieved the highest composite ratings among industry peers for ...
Breaking Medicine Technology: