Navigation Links
African-Americans with SLE more responsive to flu vaccine than patients of European descent
Date:5/18/2011

New research shows that African Americans with systemic lupus erythematosus (SLE) had a higher antibody response to influenza vaccination than European American patients. Treatment with prednisone, a history of hemolytic anemia, and increased disease flares were also linked to low antibody response in SLE patients who received the flu vaccine according to the study now available in Arthritis & Rheumatism, a peer-reviewed journal published by Wiley-Blackwell on behalf of the American College of Rheumatology (ACR).

The ACR estimates that up to 322,000 adult Americans are burdened with SLE, a chronic autoimmune disease in which the immune system fails to recognize the difference between healthy cells and foreign substances (bacteria and viruses), producing autoantibodies that attack a person's own tissues and organs. Medical evidence shows that infectious diseases are a leading cause of morbidity and mortality for lupus patients, responsible for up to 23% of all hospitalization and 20% to 50% of all deaths. Current clinical practice advises vaccination against common infectious diseases, such as influenza, for patients with lupus to reduce their risk of infection.

"SLE patients are more susceptible to infection which is likely the result of immunosuppressive therapy and inherent deficiencies of the immune system," said lead researcher Dr. Judith James, Chair of the Arthritis and Clinical Immunology Program at the Oklahoma Medical Research Foundation and Professor of Medicine at the University of Oklahoma Health Sciences Center. "Our study explored multiple factors which influence response to influenza vaccination in SLE patients with active and inactive disease activity."

For the current study, the research team collected blood specimens and disease activity details from 72 SLE patients prior to vaccination and at 2, 6, and 12 weeks following influenza vaccination. An equal number of healthy controls were also recruited and followed. Researchers assessed influenza-specific antibody responses for antibody concentration (Bmax), relative affinity (Ka), and hemagglutination inhibition (HAI). Based on the overall anti-influenza response, SLE participants were categorized as high or low responders.

After vaccination the control group showed greater increase in the total amount of native antibodies compared to all SLE patients. Both the high and low responding patients had a significantly smaller increase in apparent affinity after vaccination compared to the healthy controls. Researchers did not observe a significant difference in HAI between SLE patients and controls, and few study participants had substantial increases in HAI titers after vaccination.

Researchers reported that African American patients were 3 times more likely to be high responders to the flu vaccine than European Americans. Patients taking prednisone (10 mg/day or more) were more likely to have a low response to influenza vaccination (67%) than a high response (47%). SLE patients who had a weak response to the flu vaccine were more likely to have a history of hemolytic anemia and experience moderate to severe disease flares following vaccination, compared to patients who had a greater response.

Dr. James concluded, "Studies investigating biomarkers that could predict which lupus patients are likely to experience a flare following vaccination are already underway. This information along with serologic tests of patients expected to mount a weak response would help clinicians identify those SLE patients who may need an alternate vaccination schedule or would need to be closely monitored after receiving the influenza vaccine."


'/>"/>

Contact: Dawn Peters
healthnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. African-Americans attitudes about lung cancer may hinder prevention
2. New Report Says African-Americans and Hispanics More Likely to Have Alzheimers Disease And Dementia Than Whites
3. New Report says African-Americans Two Times More Likely to Have Alzheimers Disease and Dementia Than Whites
4. African-Americans and women are less likely to undergo bone marrow transplantation
5. Lack of trust in hospitals a major deterrent for blood donation among African-Americans
6. No link between genetic ancestry, asthma response in African-Americans
7. Keeping blood pressure in check may benefit some African-Americans with kidney disease
8. Frequency of foot disorders differs between African-Americans and whites
9. Gene linked to worsening kidney disease in African-Americans
10. Screening tool may better identify heart disease in African-Americans
11. Storytelling may help control blood pressure in African-Americans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2017)... ... 23, 2017 , ... "ProRandom is a set of camera tools that allow video editors to ... Cut Pro X," said Christina Austin - CEO of Pixel Film Studios. , With ... with video footage. ProRandom works by using a virtual camera to create the illusion ...
(Date:1/23/2017)... ... January 23, 2017 , ... ... (OREF), in partnership with the American Society of Anesthesiologists® (ASA®), the Foundation ... the American Academy of Orthopaedic Surgeons (AAOS) and the Cigna Foundation, encourages ...
(Date:1/23/2017)... (PRWEB) , ... January 23, 2017 , ... “The Inn at the Mill”: a ... unexpected fears in her quest to become happy and content. , “The Inn at ... Pennsylvania, has also lived in Germany and Vermont and is now living in Berks County ...
(Date:1/23/2017)... ... January 23, 2017 , ... ... programs and resources at seafoodnutrition.org/programs and seafoodnutrition.org/resources to assist in teaching communities ... These resources have been developed for use by nutrition educators and influencers ...
(Date:1/23/2017)... , ... January 23, 2017 , ... “Some Infallible Characteristics ... the Father. “Some Infallible Characteristics of Christ” is the creation of published author, Rev. ... a Baptist Church for thirteen years, a preacher for over nineteen, a pastor for ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... 23, 2017 LifeVac, the revolutionary device that ... and prevented choking deaths, welcomes Steve Way , ... LifeVac team as Official Spokesperson. "We ... team," said Arthur Lih , Founder and CEO ... and his mission to raise awareness about the physically ...
(Date:1/23/2017)... Jan 23, 2017 Research and Markets has announced ... Trends - Product - Forecast to 2025" report to their offering. ... Report Highlights: ... market trends to identify the investment opportunities Market forecasts ... Key market trends across the business segments, Regions and Countries ...
(Date:1/23/2017)... -- Stock-Callers.com today presents the following Generic Drugs ... ), Sophiris Bio Inc. (NASDAQ: SPHS ), Momenta ... Inc. (NASDAQ: AGRX ). These companies are part ... trade on Friday, January 20 th , 2017, with the ... health care companies in the S&P 500 also were sinking ...
Breaking Medicine Technology: