Navigation Links
African-Americans with SLE more responsive to flu vaccine than patients of European descent
Date:5/18/2011

New research shows that African Americans with systemic lupus erythematosus (SLE) had a higher antibody response to influenza vaccination than European American patients. Treatment with prednisone, a history of hemolytic anemia, and increased disease flares were also linked to low antibody response in SLE patients who received the flu vaccine according to the study now available in Arthritis & Rheumatism, a peer-reviewed journal published by Wiley-Blackwell on behalf of the American College of Rheumatology (ACR).

The ACR estimates that up to 322,000 adult Americans are burdened with SLE, a chronic autoimmune disease in which the immune system fails to recognize the difference between healthy cells and foreign substances (bacteria and viruses), producing autoantibodies that attack a person's own tissues and organs. Medical evidence shows that infectious diseases are a leading cause of morbidity and mortality for lupus patients, responsible for up to 23% of all hospitalization and 20% to 50% of all deaths. Current clinical practice advises vaccination against common infectious diseases, such as influenza, for patients with lupus to reduce their risk of infection.

"SLE patients are more susceptible to infection which is likely the result of immunosuppressive therapy and inherent deficiencies of the immune system," said lead researcher Dr. Judith James, Chair of the Arthritis and Clinical Immunology Program at the Oklahoma Medical Research Foundation and Professor of Medicine at the University of Oklahoma Health Sciences Center. "Our study explored multiple factors which influence response to influenza vaccination in SLE patients with active and inactive disease activity."

For the current study, the research team collected blood specimens and disease activity details from 72 SLE patients prior to vaccination and at 2, 6, and 12 weeks following influenza vaccination. An equal number of healthy controls were also recruited and followed. Researchers assessed influenza-specific antibody responses for antibody concentration (Bmax), relative affinity (Ka), and hemagglutination inhibition (HAI). Based on the overall anti-influenza response, SLE participants were categorized as high or low responders.

After vaccination the control group showed greater increase in the total amount of native antibodies compared to all SLE patients. Both the high and low responding patients had a significantly smaller increase in apparent affinity after vaccination compared to the healthy controls. Researchers did not observe a significant difference in HAI between SLE patients and controls, and few study participants had substantial increases in HAI titers after vaccination.

Researchers reported that African American patients were 3 times more likely to be high responders to the flu vaccine than European Americans. Patients taking prednisone (10 mg/day or more) were more likely to have a low response to influenza vaccination (67%) than a high response (47%). SLE patients who had a weak response to the flu vaccine were more likely to have a history of hemolytic anemia and experience moderate to severe disease flares following vaccination, compared to patients who had a greater response.

Dr. James concluded, "Studies investigating biomarkers that could predict which lupus patients are likely to experience a flare following vaccination are already underway. This information along with serologic tests of patients expected to mount a weak response would help clinicians identify those SLE patients who may need an alternate vaccination schedule or would need to be closely monitored after receiving the influenza vaccine."


'/>"/>

Contact: Dawn Peters
healthnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. African-Americans attitudes about lung cancer may hinder prevention
2. New Report Says African-Americans and Hispanics More Likely to Have Alzheimers Disease And Dementia Than Whites
3. New Report says African-Americans Two Times More Likely to Have Alzheimers Disease and Dementia Than Whites
4. African-Americans and women are less likely to undergo bone marrow transplantation
5. Lack of trust in hospitals a major deterrent for blood donation among African-Americans
6. No link between genetic ancestry, asthma response in African-Americans
7. Keeping blood pressure in check may benefit some African-Americans with kidney disease
8. Frequency of foot disorders differs between African-Americans and whites
9. Gene linked to worsening kidney disease in African-Americans
10. Screening tool may better identify heart disease in African-Americans
11. Storytelling may help control blood pressure in African-Americans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... ... Marcy was in a crisis. Her son James, eight, was out of control. Prone to ... , “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there ... my other children and say he was going to kill them. If we were ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. announced that ... chosen by their peers for this recognition are considered among the top 2 percent ... special honors as members of this year’s Legal Elite Hall of Fame: Miami ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, ... and the Road To Recovery® program to drive cancer patients to and from their ... to ensure the highest quality of life and ongoing independence. Getting to and ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening their pencils ... an essay contest in which patients and their families pay tribute to a genetic ... 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. ...
(Date:6/24/2016)... York, NY (PRWEB) , ... June 24, 2016 ... ... publication Haute Living, is proud to recognize Dr. Barry M. Weintraub as a ... that “the most beautiful women in the world, and the most handsome men, ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Research ... MEMS Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data ... analysis. Assessment of major trends with potential impact on the ... analysis of market segmentation which comprises of sub markets, regional ...
(Date:6/23/2016)... , June 23, 2016 , ... on Thursday, July 7, 2016 , , , , LOCATION: ... , , , , EXPERT PANELISTS:  , , , ... Senior Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and ... The global pharmaceutical industry is witnessing an exceptional era. ...
(Date:6/23/2016)...  Guerbet announced today that it has been named ... . One of 12 suppliers to receive ... support of Premier members through exceptional local customer service ... to lower costs. ... outstanding customer service from Premier," says Massimo Carrara ...
Breaking Medicine Technology: