Navigation Links
African Americans Fare Worse After Undergoing Liver Transplantation Due to Hepatitis C

ALEXANDRIA, Va. and BOSTON, Oct. 31 /PRNewswire/ -- Previous studies have shown that hepatitis C virus (HCV) progresses slower prior to liver transplantation in African Americans than in whites. However, researchers demonstrate in this study, which will be presented at the annual meeting of the American Association for the Study of Liver Diseases, that the opposite is true after transplantation, in that recurrent HCV in the transplanted liver progresses faster in African Americans than in whites. "I believe this study highlights the need, in all patients, for early close clinical monitoring, including the use of early protocol biopsies, to identify these patients that have early disease progression post-transplantation," said Jennifer Layden, MD, PhD, principal investigator on this study.

This retrospective multisite cohort study of 771 patients from 5 sites evaluated patients who had a liver transplantation between 1999 and 2008. All patients were transplanted due to liver failure caused by HCV. Data were analyzed at 6 months, 1 year, and 2 years after transplantation.

The researchers found, based on an analysis of liver biopsies performed after transplantation, that African Americans had more severe fibrosis progression and histologic inflammation compared to whites following liver transplantation for HCV. While Hispanics demonstrated similar disease progression after liver transplantation as whites, African Americans more often experienced graft failure and required repeat liver transplantation compared to whites. In addition, the hazard ratio for patient death for African Americans was 1.3, indicating a 30% higher mortality for African Americans compared to whites. The researchers concluded that African Americans who undergo liver transplantation caused by HCV had more severe fibrosis progression and histologic inflammation compared to whites undergoing the same procedure.

"While this study illustrates that HCV histologic progression occurs early and is more aggressive in African Americans, it does not allow a careful analysis of factors that may be contributing to these differences," concluded Dr. Layden, "we are conducting a multi-site prospective study to not only confirm these retrospective findings, but also examine both donor and host factors, including psychosocial, virologic, genetic and immunologic that may contribute to this important health disparity."

Abstract title:

Hepatitis C virus (HCV) progresses more rapidly after orthotopic liver transplantation (OLT) in African-Americans (AA) compared to whites (W)

About the AASLD

AASLD is the leading medical society focused solely on advancing the science and practice of hepatology and represents more than 3,300 practitioners, researchers, and allied health professionals worldwide. Founded by physicians in 1950, AASLD has upheld the standards of the profession and fostered research that generates treatment options for the millions of patients with liver diseases.

This year's Liver Meeting, held in Boston, Massachusetts, October 30 - November 3, will bring together more than 7,000 researchers from 55 countries. A pressroom will be available from October 31 at the annual meeting. For copies of abstracts and press releases, or to arrange for pre-conference research interviews contact Gregory Bologna at 703-299-9766. To pre-register, call Ann Tracy at 703-299-9766.

Press releases, additional information for the media, and all abstracts are available online at

    Media Contact: Gregory Bologna
    Press Room: October 31 - November 3, 2009
    Hynes Convention Center, Room 209
    Telephone: (617) 954-2827

    Researcher: Jennifer Layden, MD, PhD
    Phone: (312) 804-9087

This release was issued through The Xpress Press News Service, merging e-mail and satellite distribution technologies to reach business analysts and media outlets worldwide. For more information, visit

SOURCE American Association for the Study of Liver Diseases

SOURCE American Association for the Study of Liver Diseases
Copyright©2009 PR Newswire.
All rights reserved

Related medicine news :

1. African American Office of Gay Concerns (AAOGC) To Launch Status Is Everything HIV Testing Campaign
2. Study finds delay in follow-up among African-American women receiving abnormal breast finding
3. Empire BlueCross BlueShield Launches Art Heals Program with Museum for African Art, Greater New York Hospital Association
4. Maternal/child health focus of African Science Academies meeting in Ghana Nov. 9-11
5. New Research Finds Most African American Women with Lactose Intolerance Manage Their Condition by Limiting or Avoiding Dairy
6. African Americans at Significantly Higher Risk of DVT or Blood Clots
7. Grammy(R)-Nominated R&B Sensation Angie Stone Teams up With the American Diabetes Association to Encourage African-Americans to be Victorious in the Face of Diabetes
8. WXYZ-TV/Channel 7 is On Your Side with Healthy Living for Kids; Free Immunizations for Children on Sunday August 23rd at Charles H. Wright Museum of African American History
9. Leading African American Groups Call On Health Insurers to Dismiss Restrictive Practices
10. HPV Infection May Be Linked to Poor Head and Neck Cancer Survival Rates in African Americans
11. HPV infection may be linked to poor head and neck cancer survival rates in African-Americans
Post Your Comments:
(Date:11/30/2015)... , ... November 30, 2015 , ... According to Los ... people to overeat are not necessarily caused by real hunger, but instead by ... needs food. He notes that, while many patients are aware that weight loss surgery ...
(Date:11/30/2015)... (PRWEB) , ... November 30, 2015 , ... A record ... annual Regional Biotech Conference, organized by the Baruch S. Blumberg Institute. , The institute, ... of the area’s life science and biotechnology leaders for the conference, which focused on ...
(Date:11/30/2015)... ... 30, 2015 , ... A novel class of antimicrobials that ... in fighting methicillin-resistant Staphylococcus aureus (MRSA), one of the major drug-resistant bacterial pathogens, ... molecule analogs that target the functions of SecA, a central part of the ...
(Date:11/30/2015)... Scotch Plains, NJ (PRWEB) , ... November 30, ... ... is their top choice for innovative, patient centered orthopedic care. Led by ... Regardless of your injury or chronic condition, the team at Advocare Orthopedic & ...
(Date:11/30/2015)... (PRWEB) , ... November 30, 2015 , ... ... specializes in general dentistry out of Glen Ridge, NJ. He has both ... to achieve optimal mastication. He is also an expert in cosmetic dentistry. ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... , Nov. 30, 2015  QT Vascular Ltd., ... and together with its subsidiaries, TriReme Medical LLC and ... company engaged in the design, assembly and distribution of ... vascular disease, is pleased to announce that a three-judge ... Court of Appeals for the Federal Circuit ("Federal Circuit") ...
(Date:11/30/2015)... --  Royal Philips  (NYSE: PHG ; AEX: ... a fully integrated, consultative approach to enhance radiology ... management approaches that combine imaging systems, services, informatics ... delivery and reduce costs. Making its debut at ... Annual Meeting (RSNA) in Chicago ...
(Date:11/30/2015)... , Nov. 30, 2015 Nautilus Medical ... Radiology Image Management platform ( ). The release ... announced from RSNA 2015 (Radiology Society North America) in ... conference in the U.S. --> ... platform that enables access to radiology studies worldwide via ...
Breaking Medicine Technology: