Navigation Links
African-American breast cancer survivors face higher risk of heart failure
Date:3/7/2013

SAN FRANCISCO (March 7, 2013) African-American women who survive breast cancer are more likely to develop heart failure than other women who have beaten the disease, according to research being presented at the American College of Cardiology's 62nd Annual Scientific Session.

All told, these women have a 1.4-fold greater risk for heart failure compared to their white counterparts, though the likelihood of dying after developing heart failure is roughly the same. This trend remained even after taking other potential contributing factors into account, including age, high blood pressure, diabetes and use of chemotherapy agents or cardioprotective medications.

Researchers at Cleveland Clinic and Case Western Reserve University at MetroHealth in Cleveland said these findings could have important implications for the nearly 27,000 new cases of breast cancer each year among African-American women who may be at risk for subsequent heart failure.

"In general, African-American women are more susceptible to heart problems as they are disproportionately affected by high blood pressure, obesity, diabetes, high oxidative stress and even vitamin D deficiency," said Anna Valina-Toth, MD, PhD, a second-year internal medicine resident at Case Western Reserve University at MetroHealth and the study's lead investigator. "Our findings suggest that these women may require closer monitoring to detect the risk of heart failure earlier." This is the first study to establish how often heart failure occurs in a large, representative U.S. sample of breast cancer survivors, according to researchers. Heart failure is a chronic condition in which the heart can no longer pump enough blood to the body.

About half of people who have heart failure die within five years of diagnosis, according to the Centers for Disease Control and Prevention. One reason for the heightened risk of heart failure among breast cancer patients is the use of anthracycline and trastuzumab, two of the most effective chemotherapy treatments available. These agents can damage the heart depending on the amount a patient receives over the course of treatment. Dr. Valina-Toth said certain medications called cardioprotective drugs might help prevent this damage and merit investigation. "Given the risk of chemotherapy-induced cardiotoxicity with both antracycline and trastuzumab, pretreatment with cardioprotective agents such as ACE inhibitors or angiotensin II receptor blockers and beta blockers, in addition to monitoring cardiac function, need to be considered prior to initiation of chemotherapy," Dr. Valina-Toth said.

Researchers identified 26,347 women with breast cancer between 1973 and 2007 using the U.S. Surveillance Epidemiology and End Results (SEER) cancer registries that are matched to Medicare data with recorded heart failure diagnoses. Of these, 16 percent were later diagnosed with heart failure, with African-Americans having the highest heart failure occurrence of 21 percent compared to 16 percent of whites, 13 percent of Hispanics, 12 percent of Asians, and 11 percent of others including Native Americans. Most of the women, 82 percent, were age 65 or older. Authors say this is an important line of inquiry given that one out of eight American women will be diagnosed with breast cancer in her lifetime. Future lines of inquiry should evaluate whether non-invasive cardiac imaging and pretreatment with cardioprotective drugs prior to initiation of antracyclines and trastuzumab-based chemotherapy would significantly reduce the risk of heart failure in breast cancer patients, especially in African-Americans who are predisposed to developing heart failure.


'/>"/>

Contact: Beth Casteel
bcasteel@acc.org
240-328-4549
American College of Cardiology
Source:Eurekalert

Related medicine news :

1. Can weight loss help African-American breast cancer survivors?
2. Equal access to care helps close survival gap for young African-American cancer patients
3. WSU study finds overwhelming evidence of hidden heart disease in hypertensive African-Americans
4. Study finds socioeconomic status linked to weight gain and risk of obesity in African-American women
5. Tobacco use more prevalent among African-American adolescents living in public housing communities
6. HPV improves survival for African-Americans with throat cancer
7. New genetic risk factor for inflammation identified in African-American women
8. Blood pressure diet works, but adherence drops among African-Americans
9. Study helps bridge gap in understanding of suicide risk for African-American women
10. Gay African-American youth face unique challenges coming out to families
11. Exercise linked with reduced prostate cancer risk in Caucasians but not African-Americans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... June 19, ... the dangers associated with chronic pain and the benefits of holistic treatments, Serenity ... who are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a ...
(Date:6/24/2016)... ... 2016 , ... The Pulmonary Hypertension Association (PHA) learned during ... two significant new grants to support its work to advance research and patient ... recognizing patients, medical professionals and scientists for their work in fighting pulmonary hypertension ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, an ... Cheng has extensive experience with all areas of orthodontics, including robotic Suresmile technology, ... , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can be ...
(Date:6/24/2016)... ... ... makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a Fair Minimum ... by 2020 and then adjusting it yearly to increase at the same rate as the ... wage floor does not erode again, and make future increases more predictable. , The company ...
(Date:6/24/2016)... ... 24, 2016 , ... EB Medicine presented its first-ever “Issue ... conference in Ponte Vedra Beach, FL. The awards honor the outstanding work of ... and Pediatric Emergency Medicine Practice. , “With this award, we recognize the ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 ... Markets has announced the addition of the " ... offering. This ... and provides an updated review, including its applications in ... the total market, which includes three main industries: pharmaceutical ...
(Date:6/24/2016)... BEIJING , June 24, 2016 Dehaier ... or the "Company"), which develops, markets and sells medical ... China , signed a strategic cooperation agreement with ... as "Hongyuan Supply Chain") on June 20, 2016, to ... Under the strategic cooperation agreement, Dehaier will leverage Hongyuan ...
(Date:6/24/2016)... 2016 According to a new ... Pen Needles, Safety Pen Needles), Needle Length (4mm, 5mm, ... Mode of Purchase (Retail, Non-Retail) - Trends & Global ... the market for the forecast period of 2016 to ... Billion by 2021 from USD 1.65 Billion in 2016, ...
Breaking Medicine Technology: