Navigation Links
African-American breast cancer survivors face higher risk of heart failure
Date:3/7/2013

SAN FRANCISCO (March 7, 2013) African-American women who survive breast cancer are more likely to develop heart failure than other women who have beaten the disease, according to research being presented at the American College of Cardiology's 62nd Annual Scientific Session.

All told, these women have a 1.4-fold greater risk for heart failure compared to their white counterparts, though the likelihood of dying after developing heart failure is roughly the same. This trend remained even after taking other potential contributing factors into account, including age, high blood pressure, diabetes and use of chemotherapy agents or cardioprotective medications.

Researchers at Cleveland Clinic and Case Western Reserve University at MetroHealth in Cleveland said these findings could have important implications for the nearly 27,000 new cases of breast cancer each year among African-American women who may be at risk for subsequent heart failure.

"In general, African-American women are more susceptible to heart problems as they are disproportionately affected by high blood pressure, obesity, diabetes, high oxidative stress and even vitamin D deficiency," said Anna Valina-Toth, MD, PhD, a second-year internal medicine resident at Case Western Reserve University at MetroHealth and the study's lead investigator. "Our findings suggest that these women may require closer monitoring to detect the risk of heart failure earlier." This is the first study to establish how often heart failure occurs in a large, representative U.S. sample of breast cancer survivors, according to researchers. Heart failure is a chronic condition in which the heart can no longer pump enough blood to the body.

About half of people who have heart failure die within five years of diagnosis, according to the Centers for Disease Control and Prevention. One reason for the heightened risk of heart failure among breast cancer patients is the use of anthracycline and trastuzumab, two of the most effective chemotherapy treatments available. These agents can damage the heart depending on the amount a patient receives over the course of treatment. Dr. Valina-Toth said certain medications called cardioprotective drugs might help prevent this damage and merit investigation. "Given the risk of chemotherapy-induced cardiotoxicity with both antracycline and trastuzumab, pretreatment with cardioprotective agents such as ACE inhibitors or angiotensin II receptor blockers and beta blockers, in addition to monitoring cardiac function, need to be considered prior to initiation of chemotherapy," Dr. Valina-Toth said.

Researchers identified 26,347 women with breast cancer between 1973 and 2007 using the U.S. Surveillance Epidemiology and End Results (SEER) cancer registries that are matched to Medicare data with recorded heart failure diagnoses. Of these, 16 percent were later diagnosed with heart failure, with African-Americans having the highest heart failure occurrence of 21 percent compared to 16 percent of whites, 13 percent of Hispanics, 12 percent of Asians, and 11 percent of others including Native Americans. Most of the women, 82 percent, were age 65 or older. Authors say this is an important line of inquiry given that one out of eight American women will be diagnosed with breast cancer in her lifetime. Future lines of inquiry should evaluate whether non-invasive cardiac imaging and pretreatment with cardioprotective drugs prior to initiation of antracyclines and trastuzumab-based chemotherapy would significantly reduce the risk of heart failure in breast cancer patients, especially in African-Americans who are predisposed to developing heart failure.


'/>"/>

Contact: Beth Casteel
bcasteel@acc.org
240-328-4549
American College of Cardiology
Source:Eurekalert

Related medicine news :

1. Can weight loss help African-American breast cancer survivors?
2. Equal access to care helps close survival gap for young African-American cancer patients
3. WSU study finds overwhelming evidence of hidden heart disease in hypertensive African-Americans
4. Study finds socioeconomic status linked to weight gain and risk of obesity in African-American women
5. Tobacco use more prevalent among African-American adolescents living in public housing communities
6. HPV improves survival for African-Americans with throat cancer
7. New genetic risk factor for inflammation identified in African-American women
8. Blood pressure diet works, but adherence drops among African-Americans
9. Study helps bridge gap in understanding of suicide risk for African-American women
10. Gay African-American youth face unique challenges coming out to families
11. Exercise linked with reduced prostate cancer risk in Caucasians but not African-Americans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... Ky. (PRWEB) , ... October 13, 2017 , ... The ... MPH to become its next President and Chief Executive Officer, succeeding Dr. James C. ... CEO Elect beginning July 1, 2018 until Dr. Puffer’s retirement at the end of ...
(Date:10/13/2017)... ... ... Apple Rehab Shelton Lakes , which specializes in the delivery of sub-acute ... of a disaster drill on October 3rd. , Apple Rehab participated with the Shelton ... well as the Connecticut Long Term Care Mutual Aid Plan (LTC-MAP). The LTC-MAP ...
(Date:10/13/2017)... ... ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has released a ... books in the Holy Scriptures, Revelation. The Book of Revelation paints a picture of ... have tossed it off as mere rubbish, but Yisrayl Hawkins says that is because ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... advisory services for healthcare compliance program management, will showcase a range of technology ... Association for Assisted Living (NCAL) Convention and Expo to be held October 14–18, ...
(Date:10/12/2017)... ... ... The American College of Medical Informatics (ACMI) will present the 2017 Morris F. ... AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium is taking place ... the field of medical informatics, this prestigious award is presented to an individual whose ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... , Oct. 11, 2017  Caris Life Sciences ® ... fulfilling the promise of precision medicine, today announced that ... Caris, Precision Oncology Alliance™ (POA) as its 17 th ... the St. Jude Crosson Cancer Institute will help develop ... use of tumor profiling, making cancer treatment more precise ...
(Date:10/10/2017)... Oct. 10, 2017  NDS received FDA 510(k) clearance in May ... battery-powered display stand specifically designed for endoscopy environments. An innovative secondary ... a clinical solution to support the improvement of patient outcomes, procedural ... ... ...
(Date:10/5/2017)... Ill. , Oct. 5, 2017  In ... Association of Oral and Maxillofacial Surgeons (AAOMS) released ... opioids – to be used as a first-line ... pain. Recognizing ... the AAOMS White Paper "Opioid Prescribing: Acute and ...
Breaking Medicine Technology: