Navigation Links
Aerosol launches immune response in lungs to wipe out lethal infections
Date:12/3/2007

WASHINGTON - An inhaled immune system stimulant protects mice against lethal pneumococcal pneumonia and other deadly bacterial, viral and fungal infections of the lungs, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center reports at a major scientific meeting.

Their findings have implications for protecting immuno-compromised patients against infection and the general public against respiratory epidemics and biological weapons. The research is a featured presentation at the annual meeting of the American Society for Cell Biology Dec. 3 in Washington, D.C.

"This aerosol stimulates an innate immune system response in the lung lining fluid that kills the invading pathogens virtually on contact," says Brenton Scott, Ph.D., post-doctoral fellow in M. D. Anderson's Department of Pulmonary Medicine, and first author of the abstract presented at ASCB. "It also works in mice with suppressed immune systems."

The innate immune system is the body's inflammatory first response to infection or injury. It produces proteins and peptides that act as natural antibiotics to broadly kill invading bacteria, viruses or fungi.

"Pneumonia is a leading cause of death from infection in the United States and a major cause of death among cancer patients and others with suppressed immune systems," says Burton Dickey, M.D., professor and chair of pulmonary medicine and senior author of the research.

Untreated mice exposed to S. pneumoniae, the most common form of bacterial pneumonia, died within days. Mice treated with the Aerosolized Lung Innate Immune Stimulant (ALIIS), developed by the researchers, two hours before exposure had an 83 percent survival rate. All of the mice treated between 4 and 24 hours before exposure survived.

The effect slowly declines over five days, Scott says. Giving the stimulant after infection also provides some protection.

The team got similar results testing ALIIS as a protectant against lethal doses of several other types of pneumonia, as well as influenza virus, the mold aspergillus, and the Class A bioterror agents anthrax, bubonic plague, and tularemia.

ALIIS consists of a purified extract of a common bacterium, Haemophilus influenzae, that causes ear and sinus infections in children. The bacterium is essentially broken open, purified and administered as an aerosol.

Preclinical research continues, with early clinical trials - most likely to test a protective role in cancer patients - at least a year away.

The innate immune system indiscriminately targets invading pathogens and also recruits the adaptive immune system to launch a more targeted, pathogen-specific response. The adaptive immune system takes a few days to respond, Dickey says.

"Here the innate immune system is so effective, infections are cleared before the adaptive response even gears up," Dickey says.

The battle also is over before white blood cells called neutrophils, part of the innate immune system, can be called in to help. That's potentially important, Dickey says, because chemotherapy, particularly for leukemia, often wipes out a patient's neutrophils.

Dickey and Scott believe the entire defense against invaders is accomplished by local cells in the lung's lining, called the epithelium. Their research shows the epithelium floods its lining fluid with anti-microbial polypeptides in response to ALIIS inhalation. These natural antibiotics are virtually lying in wait for microbes to kill.

The team is now trying to understand exactly which of these polypeptides kills the pathogens.

Lungs are exposed to infectious agents with every breath, Scott notes, and the innate immune system plays an important role in routinely keeping the lungs healthy.

"We study airway inflammation, and mostly we think about that in a negative context - how to stop inflammation, as in the allergic inflammation that causes asthma," says Dickey. "But surely the ability of airways to become inflamed is there for a good reason. So we asked can we set off a type of inflammation that strengthens protection against infection. The answer is yes."


'/>"/>

Contact: Scott Merville
sdmervil@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Related medicine news :

1. Us TOO Launches National SEA Blue Campaign for Prostate Cancer Awareness Month
2. UPMC Health Plan Launches New Personal Health Record
3. HealthInsuranceFinders.com Launches Video Contest for Young Directors
4. Academy of General Dentistry Launches Campaign to Focus on Tooth Erosion
5. inVentiv Health Launches Fourth Business Segment: inVentiv Patient Outcomes
6. Easter Seals Launches Program for Veterans Returning from Iraq and Afghanistan with Traumatic Brain Injuries
7. Keeping Kids Healthy and Fit: The New York Kids Club Launches a Revolutionary New Fitness Program
8. Patient Advocate Foundation Launches Program to Help Uninsured Virginians with Chronic, Debilitating and Life-Threatening Illness Access Quality Healthcare
9. Mannatech Launches Phase One of New Sales and Training Tools
10. Coalition for Pulmonary Fibrosis Launches Aggressive Ad Campaign Directed at United States Congress
11. Actavis Launches Carvedilol Tablets in the U.S.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... , ... June 27, 2016 , ... ... , the only authorized OSHA Training Institute Education Center headquartered in Northern California, ... their workers from extreme heat at their worksites. Employers with workers exposed ...
(Date:6/27/2016)... (PRWEB) , ... June 27, 2016 , ... "FCPX editors ... customizable inside of Final Cut Pro X," said Christina Austin - CEO of Pixel ... style. Final Cut Pro X users can now reveal the media of ...
(Date:6/27/2016)... ... , ... TherapySites, the leading website and online ... Counseling Association. This new relationship allows TherapySites to continue to extend their ... benefits and promotional offers. , "TCA is extremely excited about this new partnership, ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... payment industry today announced its strategic partnership with Connance, a healthcare industry ... The two companies’ proven, proprietary technology combine to provide health systems, hospitals ...
(Date:6/27/2016)... ... June 27, 2016 , ... A revolution is underway. ... transport experience for the millions of people who require these medical transport services ... industry through the use of technology. Now, SmartEMS has put forth an industry-changing ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 2016 Dublin ... addition of the " Global Markets for Spectroscopy ... This report focuses on the ... review, including its applications in various applications. The report ... includes three main industries: pharmaceutical and biotechnology, food and ...
(Date:6/24/2016)... June 24, 2016 Dehaier Medical Systems Ltd. ... which develops, markets and sells medical devices and wearable ... signed a strategic cooperation agreement with Hongyuan Supply Chain ... Chain") on June 20, 2016, to develop Dehaier,s new ... cooperation agreement, Dehaier will leverage Hongyuan Supply Chain,s sales ...
(Date:6/24/2016)... 24, 2016 According to a ... (Standard Pen Needles, Safety Pen Needles), Needle Length (4mm, ... Hormone), Mode of Purchase (Retail, Non-Retail) - Trends & ... studies the market for the forecast period of 2016 ... 2.81 Billion by 2021 from USD 1.65 Billion in ...
Breaking Medicine Technology: