Navigation Links
Advances in lung cancer research announced at conference
Date:8/21/2009

PHOENIX, Ariz. Aug. 7, 2009 Dr. Glen Weiss of the Translational Genomics Research Institute (TGen) and Scottsdale Healthcare this week announced two significant advances in treating lung cancer at an international cancer research conference.

Dr. Weiss, M.D., an Associate Investigator in TGen's Cancer and Cell Biology Division and Director of Thoracic Oncology at TGen Clinical Research Services at Scottsdale Healthcare, made both announcements at the 13th World Conference on Lung Cancer in San Francisco.

In one presentation, Dr. Weiss described research that eventually could help prevent lung cancer from spreading to the brain. In non-small cell lung cancer (NSCLC), brain metastasis is a devastating complication that occurs in as many as 1 in 4 patients. The ability to identify those at risk for developing brain metastasis may guide new therapies.

A team led by Dr. Weiss found several microRNAs, which are single-stranded RNA molecules that regulate how genes control cellular development as well as several high-tech imaging characteristics all associated with the spread of lung cancer to the brain.

The biological significance of these microRNAs are being explored, and more studies are warranted, according to the team, which was funded by the Ibis Foundation of Arizona, the TGen Foundation and the Scottsdale Healthcare Foundation.

"With additional validation, this work can lead to better techniques to predict, treat and ultimately prevent brain metastasis in patients with non-small cell lung cancer," Dr. Weiss said. "Identifying the highest-risk population for brain metastasis, so that informed therapeutic trials can be undertaken, could enable a paradigmatic shift in treating these patients."

The study team included researchers from: TGen; the Virginia G. Piper Cancer Center at Scottsdale Healthcare's Scottsdale Clinical Research Institute; Scottsdale Medical Imaging LTD; and the School of Computing, Informatics and Decision Systems Engineering at Arizona State University's Ira A. Fulton School of Engineering.

In another presentation, Dr. Weiss discussed the release this week by Threshold Pharmaceuticals Inc. and the Virginia G. Piper Cancer Center at Scottsdale Healthcare of results from two Phase I clinical trials for a drug called TH-302.

The two clinical trials are both evaluating the safety and effectiveness of TH-302, a drug activated in the absence of oxygen. Both clinical trials involve patients with advanced solid tumors. In one, they are treated with TH-302 in combination with other chemotherapy agents. In the other, they are treated only with TH-302, which is produced by Threshold Pharmaceuticals of Redwood City, Calif.

In the study of those treated only with TH-302, six of eight, or 75 percent, of patients with small cell lung cancer (SCLC) "achieved stable disease or better." In the study of those treated with TH-302 in combination with other chemotherapy agents, eight of 12, or 67 percent, of patients with NSCLC "achieved stable disease or better," according to a release by Threshold and Scottsdale Healthcare. More details about the trials are available at www.shc.org/content.asp?lnavid=39.

"TH-302 is a new, novel, small molecule that is activated when cells are under conditions that lack oxygen, which is a metabolic condition characteristic of cancer cells," Dr. Weiss said. "We are excited to continue investigations with TH-302 and about the potential benefit that it might confer to people living with lung cancer."


'/>"/>

Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute
Source:Eurekalert

Related medicine news :

1. Ovation further advances development pipeline with new phase III epilepsy study
2. Medical, technological advances prompt updating of nuclear medicine technologists scope of practice
3. Major grant advances UWs clinical and translational research enterprise
4. Plastic Surgery 2007: Where Truth Behind Emerging Cosmetic Treatments Meets Amazing Reconstructive Advances
5. Innovation and Medical Advances to be Highlighted on Final Day of Inaugural AdvaMed 2007 Conference
6. Despite Advances in the Accuracy of CT Colonography in Detecting Polyps, Digestive Health Experts Urge Patients to Consider Risks and Realities
7. Advances in drug screening: building a better haystack for the needles of tomorrow
8. Advances in Cancer Research, Funding Stem Cell Research, and More at Annual Cancer Congress
9. UCLA, Tokyo University nanobiotechnology symposium at UCLA to highlight advances in nanomedicine
10. Springer adds Advances in Therapy to journals portfolio
11. NIH grant advances dentistry schools work on psychosocial stress
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... , ... October 13, 2017 , ... Ellevate Network, the ... business to advocate for action towards gender equality at their inaugural Summit in New ... the globe, and reached a social audience of over 3 million. To watch the ...
(Date:10/13/2017)... ... , ... Talented host, actor Rob Lowe, is introducing a ... episode of "Success Files," which is an award-winning educational program broadcasted on PBS ... in-depth with passion and integrity. , Sciatica occurs when the sciatic nerve in ...
(Date:10/13/2017)... ... ... “America On The Brink”: the Christian history of the United States and the ... published author, William Nowers. Captain Nowers and his wife, Millie, have six children, ... in the Navy. Following his career as a naval aviator and carrier pilot, ...
(Date:10/12/2017)... ... ... Planet Fitness, one of the largest and fastest growing franchisors and operators ... location in Covington, LA at 401 N. U.S. Highway 190, in January of 2018. ... in the Holiday Square shopping center. Its location allows it to serve both Covington ...
(Date:10/12/2017)... ... ... The American College of Medical Informatics (ACMI) will present the 2017 Morris F. ... AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium is taking place ... the field of medical informatics, this prestigious award is presented to an individual whose ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)... 22, 2017 AVACEN Medical (AVACEN) announced that ... successfully helping those with the widespread pain associated with ... Amanda in Essex, England commented, ... hair, experiencing no sleep at all, tremendous pain, with ... cannot recommend [the AVACEN 100] enough, how this has ...
(Date:9/18/2017)... KALAMAZOO, Mich. , Sept. 18, 2017 ... , and OptiMed Specialty Pharmacy of Kalamazoo, ... offer a strategic hub service that expedites and streamlines ... personal spirometer, Spiro PD 2.0, and wellness management services.  ... is a medical device used to measure lung function ...
(Date:9/12/2017)... and NEW YORK , Sept. 12, 2017 ... performance ratings for global supply chains, has published the first annual edition ... CSR performance of more than 20,400 companies evaluated by EcoVadis, based on ... 2015 and 2016. ... EcoVadis Global CSR Risk & Performance Index ...
Breaking Medicine Technology: