Navigation Links
Advances in delivery of therapeutic genes to treat brain tumors
Date:6/27/2011

New Rochelle, NY, June 27, 2011Novel tools and methods for delivering therapeutic genes to cells in the central nervous system hold great promise for the development of new treatments to combat incurable neurologic diseases. Five of the most exciting developments in this rapidly advancing field are presented in a series of articles in the June issue of Human Gene Therapy, a peer-reviewed journal published by Mary Ann Liebert, Inc. (www.liebertpub.com). The articles are available free online at www.liebertpub.com/hum

A review article by Betley and Sternson, "Adeno-Associated Viral Vectors for Mapping, Monitoring, and Manipulating Neural Circuits," highlights the latest genetic tools that are enabling cell type-specific delivery of transgenes for studying the structure and function of neuronal circuits.

Ryu et al. report on the successful use of stem cells derived from human umbilical cord blood to deliver a novel therapeutic geneinterleukin-12to the brain for long-term anti-tumor activity against gliomas, a deadly type of brain tumor. Their innovative strategy is presented in the research report "Gene Therapy of Intracranial Glioma Using Interleukin 12-Secreting Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells."

"High-Density Lipoprotein Facilitates In Vivo Delivery of α-Tocopherol-Conjugated Short-Interfering RNA to the Brain" by Uno et al. describes a combination strategy for dramatically improved delivery of siRNAs to the brain to silence genes involved in neurological disease.

Loss of the neurotrophic factor GDNF contributes to the development of neuropathic pain caused by trauma or neurodegenerative disease. Shi et al. present data to support this link and demonstrate the potential to replace GDNF via intramuscular gene delivery in the article "Glial Cell Line-Derived Neurotrophic Factor Gene Transfer Exerts Protec
'/>"/>

Contact: Vicki Cohn
vcohn@liebertpub.com
914-740-2100
Mary Ann Liebert, Inc./Genetic Engineering News
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. New advances in lipid genetics lead to better detection and prevention of major diseases
2. Led by advances in chemical synthesis, scientists find natural product shows pain-killing properties
3. Society of Interventional Radiology addresses radiation safety, advances best practices
4. Experts to discuss advances in dental sleep medicine treatments for sleep-disordered breathing
5. UT Southwestern research advances fight against kidney cancer
6. Research presented at 2011 GU Cancers Symposium highlights advances in treatment of prostate cancer
7. RIC study suggests researchers are entering a new era of advances in brain research
8. Long-shot discovery may lead to advances in treating anxiety, memory disorders
9. Roundup: 2010 Advances in Heart Disease and Stroke Care
10. Ovarian cancer advances when genes are silenced
11. Blood Cancer Advances May Improve Survival
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Advances in delivery of therapeutic genes to treat brain tumors 
(Date:1/22/2015)... (PRWEB) January 22, 2015 Deer Path of ... host a Valentine’s Day Happy Hour from 3 p.m. to 4 ... 12500 Regency Parkway in Huntley, Illinois, serves adults with physical disabilities ... event will include Valentine's Day treats, games and sweetheart-themed karaoke. , ...
(Date:1/22/2015)... Woodloch Pines, an all-inclusive family resort ... as the number one best large hotel for families in ... for their annual Travelers’ Choice Awards. , TripAdvisor represents ... is home to millions of unbiased and honest traveler reviews. ...
(Date:1/22/2015)... is a famous wedding dress company offering many trendy designs. ... Facebook, Twitter, and Pinterest. The fans will have an opportunity ... every week. , Moreover, the company has extended its 2015 ... homepage for more information. , Angelweddingdress is a ...
(Date:1/22/2015)... Dallas, TX (PRWEB) January 22, 2015 ... the issue of experience and person-centeredness in the long-term ... moving towards action across the continuum. The paper, “The ... the Continuum,” engages perspectives and practices of the patient, ...
(Date:1/22/2015)... Plainsboro, NJ (PRWEB) January 22, 2015 ... advocate and keynote speaker at the upcoming 32nd ... by ACCME-accredited Physicians’ Education Resource®, LLC (PER®) , ... breast would have gone undetected if she had not ...
Breaking Medicine News(10 mins):Health News:Deer Path of Huntley Affordable Assisted Living to Host Valentine's Day Happy Hour 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 3Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 5Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 6
... This release is available in French . ... the Government of Canada,s commitment to strengthening Canada,s healthcare ... today funding for 25 policy-relevant research projects across six ... improving healthcare and health systems for Canadians," said Minister ...
... Develop Promising New Cancer Fighting Drug, Vemurafenib ... for Melanoma and Other Life-Threatening Diseases WASHINGTON, ... U.S. Department of Energy,s (DOE,s) national laboratories is ... to the swine flu, and, most recently, enabled ...
... Aug. 18 (HealthDay News) -- Black researchers are 10 ... receive research grants from the U.S. National Institutes of ... findings are unacceptable, NIH officials pledged immediate action to ... individual applicants between 2000 and 2006 reported that Asian ...
... , THURSDAY, Aug. 18 (HealthDay News) -- Many doctors continue ... guidelines say some women can wait much longer between tests. ... Katherine Roland, a behavioral scientist at the U.S. Centers for ... with the guidelines," Roland said. The downsides of too-frequent ...
... Several prominent cancer researchers are now joining forces in an ... tumors will be difficult to treat and to find out ... of use. The study is to be directed by Tobias ... The study involves a hundred cancer patients, suffering ...
... For the first time, researchers at Seattle ... using serial positron emission tomography (PET) scans, using ... effectiveness of estrogen-blocking and estrogen-depleting therapy in patients ... research are published online in Clinical Cancer ...
Cached Medicine News:Health News:Research improving health care 2Health News:DOE laboratories help develop promising new cancer fighting drug, vemurafenib 2Health News:Black Scientists Less Likely to Receive NIH Research Grants 2Health News:Annual Pap Tests Often Ordered But Unneeded: Study 2Health News:Annual Pap Tests Often Ordered But Unneeded: Study 3Health News:Major advanced cancer study to be led by Uppsala University 2Health News:PET scans confirm effectiveness of estrogen-blocking drugs in breast cancer patients 2
(Date:1/23/2015)... MYERS, Fla. , Jan. 23, 2015  Today the ... of Novartis, Bexsero® for the prevention of serogroup ... 25. Bexsero and Pfizer,s vaccine Trumenba®, which received FDA ... helping prevent this devastating disease. "I ...
(Date:1/23/2015)... Partnership to Fight Chronic Disease (PFCD) released a public opinion poll ... new study analyzing the impact of increased cost sharing on patient ... to educate policy makers and the public on the costs of ... how the Iowa healthcare exchange could be ...
(Date:1/23/2015)... , Jan. 23, 2015 More than a third ... quarter of those with private insurance, filled a prescription for ... a report in this week,s Morbidity and Mortality Weekly Report ... care providers to treat moderate to severe pain.  They are ...
Breaking Medicine Technology:The National Meningitis Association (NMA) Applauds FDA Approval of Second Vaccine To Protect Against Serogroup B Meningococcal Disease 2New research shows Iowa health exchange would benefit from improvements 2New research shows Iowa health exchange would benefit from improvements 3Opioid painkillers widely prescribed among reproductive age women 2Opioid painkillers widely prescribed among reproductive age women 3
... Data from experimental work on the use,of ... this week at the,International Society for Heart and ... donors after cardiac death,(DCD), also known as non-heart-beating ... shortage of suitable donor organs for lung, and,possibly ...
... Institute,s NABTT ... Consortium -, ... expansion of the clinical program for the company,s lead,product candidate, BSI-201, ... first poly ADP-ribose polymerase,(PARP) inhibitor in BiPar,s DNA repair portfolio, crosses ...
Cached Medicine Technology:Research Presented at ISHLT Shows Promise of Addressing Critical Organ Shortage and Better Organ Preservation 2Research Presented at ISHLT Shows Promise of Addressing Critical Organ Shortage and Better Organ Preservation 3BiPar Sciences Expands Clinical Program for BSI-201, a Novel DNA Repair Inhibitor, in Brain Cancer 2
To elevate, dissect, scrape and apply traction to bone and soft tissue....
Diamond Point Bone Probe with Ortho-Grip® silicone rubber palm style handles and,stainless steel impactor caps....
The AV Plus DX pacing lead is designed for use with the St. Jude Medical Affinity VDR pulse generator. This single-lead pacing system provides reliable pacing therapy with the added benefits of AV sy...
Steroid eluting pacemaker leads...
Medicine Products: