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Advances in brain imaging can expedite research and diagnosis in Alzheimer's disease
Date:10/11/2011

>It's known that the presence of an ApoE e4 (e4+) allele increases the risk of developing AD. There is an adverse relationship between e4+ status and brain structure and function in mild cognitive impairment; the presence of an e2 allele may be protective. In "Presence of ApoE e4 Allele Associated with Thinner Frontal Cortex in Middle Age," investigators examined whether the brain cortex thinning is the result of the disease, or a pre-existing endophenotype. Drawing on imaging data from a large national sample, the study examined the influence of ApoE on regional brain thickness and structure. The presence of the e4+ demonstrated significantly thinner cortex in the frontal areas, and may explain susceptibility to AD. The presence of the e2 allele was related to thicker cortex, suggesting a protective role.

In all, 31 papers discuss the advances in numerous imaging methodologies that are being used to increase our understanding of the pathophysiological basis of AD and drive us toward new therapies for this complex brain disorder. "Ultimately, the prospects for neuroimaging to enhance clinical care in Alzheimer's disease are bright as researchers collaborate and clinicians become informed about innovations and advances," says George Perry, PhD, Editor-in-Chief, Journal of Alzheimer's Disease, and Dean and Professor, College of Sciences, University of Texas at San Antonio.


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Contact: Daphne Watrin
d.watrin@iospress.nl
31-206-883-355
IOS Press
Source:Eurekalert

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