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Advances in brain imaging can expedite research and diagnosis in Alzheimer's disease
Date:10/11/2011

e healthy people, too much money, and too many years to evaluate the range of promising presymptomatic treatments using clinical endpoints," says lead author Eric M. Raiman, of the Banner Alzheimer's Institute and the University of Arizona. The project will use brain imaging studies, cerebrospinal fluid biomarkers, and cognitive measures to evaluate AD-modifying treatments earlier than is otherwise possible and to determine the extent to which the treatment's brain imaging and other biomarker effects predict a clinical benefit, among other outcomes.

Dr. Ashford comments that "even when imaging data are not applied to the management of individual patients, these data have the potential to assist in evaluating other components of care and diagnosis. To the extent that imaging can more sensitively measure brain integrity than existing techniques, novel treatments may be discovered because beneficial effects of treatments are not detectable with other methods."

Two articles in the supplement offer intriguing insights into the relationship between cortical thinning and AD. In "Relationship Between CSF Biomarkers of Alzheimer's Disease and Rates of Regional Cortical Thinning in ADNI Data," investigators from the Department of Veterans Affairs Medical Center, San Francisco, the University of California and the Hospital of the University of Pennsylvania tested the association between rates of regional brain cortex thinning and reduced amyloid (Ab1-42) and higher tau concentrations. Using data from the Alzheimer's Disease Neuroimaging Initiative, they found that these biomarkers were associated with increased rates of brain tissue loss, and that the patterns varied across the healthy elderly and the mildly cognitively impaired. "The finding of faster progression of brain atrophy in the presence of lower Ab1-42 levels and higher p-tau levels supports the hypothesis that they are measures of early AD pathology," says lead author Duygu Tosun.

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Contact: Daphne Watrin
d.watrin@iospress.nl
31-206-883-355
IOS Press
Source:Eurekalert

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