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Advanced targeted therapies effective as first-line treatment for lung cancer
Date:8/1/2009

s M.D. Anderson Cancer Center and the study's lead author. "The fact that more patients had an improvement in the symptoms from their lung cancer suggests that the drug could be important for the future management of this disease."

Dr. Herbst will present this study on Saturday, August 1, 2009 at 10:40 am PT in Moscone West, Room 2007-2011, Level 2. Please note that this research was also presented at the 2009 ASCO Annual Meeting.

A RANDOMIZED PHASE III STUDY OF GEFITINIB VERSUS STANDARD CHEMOTHERAPY (GEMCITABINE PLUS CISPLATIN) AS A FIRST-LINE TREATMENT FOR NEVER-SMOKERS WITH ADVANCED OR METASTATIC ADENOCARCINOMA OF THE LUNG (ABSTRACT # PRS.4)

Doctors are constantly on the look out for advancements to better treat and tailor cancer treatment to the individual. Targeted therapies have been introduced that have improved standard chemotherapy approaches. Combining targeted therapies in specific patients with lung cancer may reduce the need for chemotherapy, and increased understanding of the targets involved in the pathogenesis of lung cancer may help to individualize drug therapy. One of these targeted therapies is gefitinib, a tyrosine kinase inhibitor (TKI) that targets the epidermal growth factor receptor (EGFR), a protein that causes cancer cells to divide. Gefitinib has shown high response rate and extended survival in never-smoker lung cancer patients, especially in those with an EGFR mutation.

In this randomized phase III trial, researchers sought to compare the efficacy of gefitinib as a first-line treatment with standard chemotherapy in patients who were never-smokers. Investigators randomized 309 never-smokers living with late-stage lung cancer into two groups. One group received gefitinib and the other group received chemotherapy.

While the gefitinib did not show an improved overall survival, results showed the group receiving gefitinib had a higher response rate and a significantly better progression-f
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Contact: Liz Wulderk
lwulderk@spectrumscience.com
443-506-1931
International Association for the Study of Lung Cancer
Source:Eurekalert

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