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Advanced targeted therapies effective as first-line treatment for lung cancer
Date:8/1/2009

e West, Room 2001-2005, Level 2.

VANDETANIB PLUS DOCETAXEL VERSUS DOCETAXEL AS SECOND-LINE TREATMENT FOR PATIENTS WITH ADVANCED NON-SMALL CELL LUNG CANCER: A RANDOMIZED, DOUBLE-BLIND PHASE III TRIAL (ZODIAC) (ABSTRACT # C2.2)

Vandetanib is an orally administered medication that targets two receptors already known to play a role in non-small cell lung cancer (NSCLC) epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF). These receptors are targeted separately by other drugs, but vandetanib is the first drug designed to target both.

In previous research, the addition of vandetanib to chemotherapy was shown to prolong the progression-free survival (PFS) and improve response rate in patients with previously treated advanced NSCLC. To expand upon these findings, researchers conducted a phase III study to further evaluate whether vandetanib plus chemotherapy prolonged the PFS of advanced NSCLC patients when compared to chemotherapy alone.

Over two years, 1,391 patients were recruited to participate in the study. Patients were randomized to receive chemotherapy with vandetanib or chemotherapy with the placebo. A statistically significant difference in PFS was seen (HR = 0.79) in favor of vandetanib. The median PFS time was 17.3 weeks in the vandetanib arm versus 14 weeks in the control arm. While there was no statistical difference in overall survival, a significant improvement in objective response rate was observed. Vandetanib treatment was also associated with a statistically significant improvement in symptoms related to the underlying cancer.

"Clearly in a disease as heterogeneous as lung cancer, the need to target multiple pathways has become paramount. This agent, targeting two key pathways critical for non-small cell lung cancer growth and metastasis, is novel and could play a key role," said Roy S. Herbst, M.D., Ph.D., chief of thoracic medical oncology at the University of Texa
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Contact: Liz Wulderk
lwulderk@spectrumscience.com
443-506-1931
International Association for the Study of Lung Cancer
Source:Eurekalert

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