Navigation Links
Advanced targeted therapies effective as first-line treatment for lung cancer
Date:8/1/2009

CLINICAL OUTCOME WITH ERLOTINIB: RESULTS FROM THE PHASE III PLACEBO-CONTROLLED SATURN STUDY OF MAINTENANCE THERAPY FOR ADVANCED NSCLC (ABSTRACT # B9.1)

In another segment of the SATURN study, researchers further examined the efficacy of erlotinib as a maintenance therapy in non-progressive disease patients after first-line platinum-containing chemotherapy. Currently the indications for erlotinib are limited to its use as a second- or third-line agent after failure of first-line chemotherapy.

To expand the potential for the use of erlotinib, Wolfram Brugger, M.D., Ph.D., head of the Department of Hematology, Oncology and Immunology at Schwarzwald-Baar Clinic in Germany, and his team of researchers conducted the phase III, placebo-controlled SATURN study to evaluate the efficacy of erlotinib as a maintenance therapy.

Dr. Brugger enrolled a total of 889 non-small cell lung cancer (NSCLC) patients and treated them with either 150mg/day of erlotinib or placebo after four cycles of platinum-based doublet chemotherapy. Researchers evaluated molecular markers including EGFR protein and EGFR gene copy number, EGFR- and KRAS-mutations and EGFR polymorphism in order to potentially identify predictive markers for erlotinib therapy.

Both arms of the trial were well represented in patient and disease characteristics, specifically regarding biomarker status. Dr. Brugger and his team determined that the use of erlotinib provided a clinical benefit in terms of both progression-free and overall survival for all patients, regardless of the status of biomarkers.

"This study demonstrates the tremendous potential for erlotinib and the potential for its expanded use as a maintenance therapy," says Dr. Brugger. "The addition of an effective tool physicians can use to maintain a cancer-free state in their patients is crucial to prolonged survival."

Dr. Brugger will present this study on Saturday, August 1 at 2:30 pm PT in Moscon
'/>"/>

Contact: Liz Wulderk
lwulderk@spectrumscience.com
443-506-1931
International Association for the Study of Lung Cancer
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8

Related medicine news :

1. Smith & Nephew Highlights Advanced Wound Management Progress
2. Patient safety advanced by revised heparin standards
3. AstraZeneca Submits New Drug Applications for ZACTIMA(TM) in Second-Line Advanced Non-Small Cell Lung Cancer
4. Penile Prosthesis Surgery Infection Rates Reduced With The No-Touch Technique By Dr. J. Francois Eid of Advanced Urological Care
5. Leading Independent Analyst Firm States Silver Creek Systems Holds A Virtual Monopoly In Delivering Advanced Product Data Quality Capabilities
6. Surgery remans an option for advanced lung cancer
7. Nexavar in Combination with Chemotherapy Shown to Extend Progression-Free Survival in Patients with Advanced Breast Cancer
8. Hendrick Health System Deploys Sentillions Tap & Go Advanced Authentication Solution
9. Centocor Ortho Biotech Statement on the FDA ODAC Opinion Regarding DOXIL(R) for Treatment of Advanced Breast Cancer
10. Marienkrankenhaus Hamburg Installs Visage(R) CS Enterprise Wide Advanced Visualization Solutions
11. Advanced Bag Design for Cryopreservation: The New CryoMACS(R) Freezing Bag
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... 2014 The federal court overseeing ... blood thinner caused life-threatening episodes of internal bleeding ... for the proceeding, Bernstein Liebhard LLP reports. According ... plans to select lawyers to serve as Liaison ... appointing a Plaintiffs’ Steering Committee, which will coordinate ...
(Date:12/24/2014)... (PRWEB) December 24, 2014 Mike ... sat down with Derek Fenwick, PT, MBA, GCS, ... that will stem from the passing of the ... (IMPACT Act). In this taping of the Infinicast, the ... XVIII of the Social Security Act to standardize post-acute ...
(Date:12/24/2014)... 24, 2014 (HealthDay News) -- Hepatitis C infection does not ... a new study. Treatment advances have made it possible ... develop memory and thinking problems, mood swings and other types ... It,s believed that long-term infections with other viruses -- ... the brain. One of the prime suspects has been the ...
(Date:12/24/2014)... HealthDay Reporter WEDNESDAY, Dec. 24, ... start smoking or drinking with each additional symptom they ... new research suggests. "Our findings underscore the ... use as [these] children approach adolescence," said study author ... Group, which is part of Cincinnati Children,s Hospital. "This ...
(Date:12/24/2014)... For chic ladies, new fashionable outfits are necessary when heading ... Wish List, Angeldress.co.uk has chosen some of their ... holiday wardrobe by launching a promotion on its cheap clothes ... of 80% off, like a cheap suit. , “All items ... wedding dresses are among the hottest items in the global ...
Breaking Medicine News(10 mins):Health News:Court Overseeing Federal Xarelto Lawsuits Issues Coordination Order, Bernstein Liebhard LLP Reports 2Health News:Court Overseeing Federal Xarelto Lawsuits Issues Coordination Order, Bernstein Liebhard LLP Reports 3Health News:Latest Episode of Infinicast Features Infinity Rehab President Discussing IMPACT Act of 2014 and Changes for Post-Acute Therapy Providers in 2015 2Health News:Hepatitis C Infection Isn't Related to HIV Brain Woes: Study 2Health News:ADHD May Raise Teens' Odds for Smoking, Drinking 2Health News:ADHD May Raise Teens' Odds for Smoking, Drinking 3Health News:Angeldress.co.uk Starts Its Big Sales by Offering Various Kinds of Cheap Clothes and Fashion Accessories 2
... 2009 Inuit children have the highest rate of ... but new research shows that lowering risk factors though ... improve health for Inuit children and lower health care ... conducted by Dr. Anna Banerji, a pediatric infectious disease ...
... Elimination of funding for the Governor,s Office of ... budget plan would end a wide range of critical ... cost increases, improving quality of care and expanding access, ... years the small "think tank" office has been working ...
... 21 Mayo Clinic researchers have found that bipolar ... as diabetes, depression, asthma or coronary artery disease. These ... claim costs. Specialty care costs (the costs of seeing ... for bipolar patients. Results of this review are being ...
... Wash., May 21 Advana Science ( www.advanascience.com ... in Alzheimer,s disease, has been named scientific advisor to the ... (Volume 16, Issue 3), Dr. Smith was ranked third ... in March 2009. Dr. Smith brings over 20 years ...
... of Alcohol Outlets are More Likely to Contain ... 21 Communities containing larger numbers of stores ... levels of underage alcohol access, according to a ... Center of the Pacific Institute for Research and ...
... in Sydney and Boston believe they may have identified a ... a very troublesome problem for people with diabetes. , The ... blood sugar (glucose) levels fall, the liver makes and releases ... liver doesn,t stop making sugar when it should, so blood ...
Cached Medicine News:Health News:First of its kind study identifies risk factors for LRTIs in Inuit children 2Health News:Senate Republican Budget Would End Health Initiatives That Save Lives and Money 2Health News:Senate Republican Budget Would End Health Initiatives That Save Lives and Money 3Health News:Senate Republican Budget Would End Health Initiatives That Save Lives and Money 4Health News:Specialty Care Costs for Patients With Bipolar Disorder Are Higher Than Diabetes and Other Chronic Diseases 2Health News:Leading Alzheimer's Disease Researcher Mark A. Smith, PhD Named Scientific Advisor at Advana Science 2Health News:Leading Alzheimer's Disease Researcher Mark A. Smith, PhD Named Scientific Advisor at Advana Science 3Health News:Communities Containing More Alcohol Outlets Show Increased Underage Alcohol Access 2Health News:Communities Containing More Alcohol Outlets Show Increased Underage Alcohol Access 3Health News:Regulating the sugar factory in diabetes 2
(Date:12/24/2014)... Soligenix, Inc. (OTCQB: SNGX) (Soligenix or ... that address unmet medical needs in the areas ... on December 24, 2014 it closed its previously ... raised approximately $2.3 million in gross proceeds from ... proceeds from the offering to fund its research ...
(Date:12/24/2014)... and FARMINGTON, Conn. , Dec. ... MKT: PTN), a biopharmaceutical company developing targeted, receptor-specific ... significant unmet medical need and commercial potential, today ... placement of 2,050,000 shares of its common stock ... of its common stock.  Funds under the management ...
(Date:12/24/2014)... , Dec. 23, 2014  Advanced Medical ... company engaged primarily in the development of brachytherapy ... applications, today announced that it has filed a ... and Drug Administration ("FDA") for marketing clearance for ... 513(f)(2) of the U.S. Food, Drug and Cosmetic ...
Breaking Medicine Technology:Soligenix Announces Closing of Public Offering of Units 2Soligenix Announces Closing of Public Offering of Units 3Palatin Completes $20 Million Equity and $10 Million Debt Financings 2Palatin Completes $20 Million Equity and $10 Million Debt Financings 3Palatin Completes $20 Million Equity and $10 Million Debt Financings 4Advanced Medical Isotope Corporation Files a "de novo" Submission for Y-90 RadioGel(TM) Device 2Advanced Medical Isotope Corporation Files a "de novo" Submission for Y-90 RadioGel(TM) Device 3
... 2010 ACCESS PHARMACEUTICALS, INC. ... ACCP ), a biopharmaceutical company leveraging its proprietary drug-delivery ... supportive care and diabetes, announced that it will be ... Technology Meeting, entitled, "Preclinical Studies with Cobalamin™ Nanoparticles for ...
... NVAX ) a clinical-stage biopharmaceutical company, announced today ... Novavax will be presenting at the Lazard 7th Annual Healthcare ... 2010 at 1:10pm local time at the St. Regis Hotel, ... can be accessed via the Company website at www.novavax.com ...
Cached Medicine Technology:Access Pharmaceuticals Presents CobOral™ Insulin Research at 10th Annual Diabetes Technology Meeting on November 11-13, 2010 2Access Pharmaceuticals Presents CobOral™ Insulin Research at 10th Annual Diabetes Technology Meeting on November 11-13, 2010 3
... consists of a 5-megapixel color matrix ... colors, camera control unit with a ... crystal clear LCD display monitor. PC/Mac ... for live image displays and camera ...
This compact photomicrographic system assures simple operation to achieve the exposure accuracy required for sophisticated photomicrography in most research and clinical environments....
Semi-Automated Chemistry Analyzer with model screen master. The Screen Master incorporates many powerful features in one compact unit. Useful for biochemical investigations, enzymatic, immunoturbidi...
... for Geometric Data Hemastainer. Formulated ... are quality control tested on ... proper staining and absence of ... for a minimum of eight ...
Medicine Products: