Navigation Links
Advanced-stage ovarian cancer patients with BRCA live longer, may respond better to treatment
Date:3/10/2008

Tampa, Fla. - Two abstracts underscoring the importance of testing for BRCA1/2 mutations in women with ovarian cancer were presented at this week's Society of Gynecologic Oncologists 39th Annual Meeting on Women's Cancers, by researchers from The University of Texas M. D. Anderson Cancer Center.

In the first study, a multicenter research team led by M.D. Anderson found advanced- stage ovarian cancer patients with non-Ashkenazi Jewish BRCA (non-AJ BRCA) mutations experience longer progression-free and overall survival rates compared to those with sporadic ovarian cancer. The data confirms previous research which reported that among ovarian cancer patients of Ashkenazi-Jewish heritage, BRCA1/2 mutations (AJ BRCA) are associated improved long-term survival.

For this study, researchers examined 85 advanced-stage ovarian cancer patients with non-AJ BRCA mutations and 116 patients who did not express any type of BRCA mutation. Compared to patients without BRCA mutations, non-AJ BRCA carriers had longer progression-free survival of 19.0 vs. 27.8 months and improved overall survival of 65.6 vs. 101.4 months. Non-AJ BRCA patients had a 2.15 times greater odds of complete response to initial chemotherapy response over sporadic, non-carrier patients.

Karen Lu, M.D., associate professor in the Department of Gynecologic Oncology at M. D. Anderson and senior author on the study said the difference in survival rates indicate that individuals with BRCA mutations might respond better to standard chemotherapy for ovarian cancer. "Thus, it becomes increasingly valuable to know a patient's BRCA status to guide and personalize treatment decisions," Lu said.

Majority of Patients Unaware BRCA Testing Available

A second study conducted at M. D. Anderson concluded that, despite being available for more than 10 years, a majority of women with ovarian cancer were unaware genetic counseling and testing for BRCA1/2 mutations was
'/>"/>

Contact: Robyn Stein
robyn.stein@gabbe.com
212-220-4444
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Neupro(R) Filed with the FDA for the Treatment of Advanced-Stage Parkinsons Disease
2. Gleevec May Disrupt Ovarian Function
3. U of Minnesota study finds thalidomide shows promise for treatment of recurrent ovarian cancer
4. Researchers identify and shut down protein that fuels ovarian cancer
5. Combo Treatment Best for Melanoma, Advanced Ovarian Cancer
6. Vaccine/antibody therapy effective, milder side effects in melanoma and ovarian cancer
7. Yale test detects early stage ovarian cancer with 99 percent accuracy
8. Study reveals why certain ovarian cancers develop resistance to platinum-based chemotherapy
9. Oral Contraceptives Cut Ovarian Cancer Risk
10. Caffeine May Lower Ovarian Cancer Risk
11. Ovarian cancer risk not affected by alcohol and smoking, but reduced by caffeine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2015)... (PRWEB) , ... September 01, 2015 , ... ... by members of the American Society for Dermatologic Surgery, according to a new ... 2015 ASDS Consumer Survey on Cosmetic Dermatologic Procedures – which reflects views on ...
(Date:9/1/2015)... ... 01, 2015 , ... Negative pressure wound therapy (NPWT) entails ... remove exudates, fluid, and infectious materials to prepare the wound for healing and ... and canisters, etc.) is projected to expand continuously through 2021. , Rising patient ...
(Date:9/1/2015)... ... September 01, 2015 , ... OncLive® today ... U.S. News & World Report, to provide breaking news and information about the ... groups within OncLive, which provides oncologists resources and information?they need to deliver the ...
(Date:9/1/2015)... , ... September 01, 2015 , ... ... monitoring and analysis of pet vital signs and activity, today announced its integration ... of the most popular and widely-adopted veterinary hospital Practice Management Software packages in ...
(Date:9/1/2015)... ... September 01, 2015 , ... e-Spirit ... version 5.2 of the FirstSpirit Content Management System with new capabilities and enhancements ... version of FirstSpirit, companies will be well on their way to achieving digital ...
Breaking Medicine News(10 mins):Health News:Survey: Consumers Prefer ASDS Members 2Health News:Survey: Consumers Prefer ASDS Members 3Health News:World Negative Pressure Wound Therapy Market Assessed by GlobalData in In-demand Report Published at MarketPublishers.com 2Health News:World Negative Pressure Wound Therapy Market Assessed by GlobalData in In-demand Report Published at MarketPublishers.com 3Health News:OncLive® and Cleveland Clinic Team up to Provide News, Information About Cancer Research and Patient Care 2Health News:OncLive® and Cleveland Clinic Team up to Provide News, Information About Cancer Research and Patient Care 3Health News:Petpace-Cornerstone Integration Lowers Overhead, Raises Data Visibility for Veterinary Practices 2Health News:e-Spirit boosts Corporate Content Cloud initiative with release of FirstSpirit 5.2 2Health News:e-Spirit boosts Corporate Content Cloud initiative with release of FirstSpirit 5.2 3
... at Johns Hopkins and the University of Michigan have developed ... ,The findings will be published in the ... of Sciences. The study has implications for treating people who ... in which nerves are wrenched from the spinal cord. The ...
... Body mass index (BMI), which is the ratio of height and ... patients. A lower BMI is associated with a lesser weight// and ... with obesity and its allied health risks. , ... that measure how the weight is distributed on the body are ...
... charity organization it was shocking to find that about three-quarters ... of chronic obstructive pulmonary disease (COPD). , The ... disease. COPD is UK’s fifth-biggest killer disease as it affects ... deaths a year. The medical charity organization called the Developing ...
... Department of Health have admitted that some nursing homes do ... This does not concur with the existing legislation. ,Fine ... on more illegal charges was worrying. "It is absolutely disgraceful ... the income of a spouse of a long-stay public nursing ...
... Hospital, gauged the cost-benefit of shifting the responsibility of caring ... said that there was no major economic savings in such ... the driving force behind the idea of such a shift, ... 220 senior patients, recouping from illness, that there were not ...
... Medical education in Australia is getting caught in a number ... a wake up call. This coupled with dwindling// numbers of ... the field of healthcare education. ,Australian Medical Association president ... that parents and students will borrow, scrimp and save in ...
Cached Medicine News:Health News:Scientists Coax Nerve Fibers to Regrow After Spinal Cord Injury 2Health News:Scientists Coax Nerve Fibers to Regrow After Spinal Cord Injury 3Health News:Scientists Coax Nerve Fibers to Regrow After Spinal Cord Injury 4Health News:A high BMI may not determine obesity, researchers say 2
(Date:9/1/2015)... 1, 2015 Ardelyx, Inc. (NASDAQ: ... gastrointestinal and cardio-renal diseases, today announced that Sanofi ... and license agreement for Ardelyx,s portfolio of NaP2b ... payment associated with termination and the return of ... Sanofi entered into an option and license agreement ...
(Date:9/1/2015)... 1, 2015 Emerus Holdings, a national ... inpatient and diagnostic care in partnership with leading ... definitive agreement to receive a strategic investment from ... leading health care investment firm. Emerus ... acute episodic and ambulatory clinical services to communities ...
(Date:9/1/2015)... --  Alpha Imaging LLC , a leading distributor of advanced medical ... that they have been awarded exclusive rights to represent the complete ... new territory supplements Alpha Imaging,s existing Shimadzu sales and service responsibilities ... , Indiana , Pennsylvania , ... West Virginia , Delaware and ...
Breaking Medicine Technology:Ardelyx Regains NaP2b Program from Sanofi 2Ardelyx Regains NaP2b Program from Sanofi 3Emerus Announces Significant Strategic Investment By Welsh, Carson, Anderson & Stowe 2Emerus Announces Significant Strategic Investment By Welsh, Carson, Anderson & Stowe 3Alpha Imaging Expands Shimadzu Territory 2
... at Brigham and Women,s,Hospital found that patients taking cannabinoid ... were unrelated to relief from their pain,symptoms. Results ... the addictive,potential of this class of pain medicine, were ... Annual Meeting. , In the ...
... The Netherlands, January 28 ,Amsterdam Molecular Therapeutics ... of,human gene therapy, announced today during the ... showing that one treatment of its lead ... and clinically important,lowering of the incidence of ...
Cached Medicine Technology:Study of Cannabinoid Medicine for Pain Found Patients Got 'High,' but Effects Not Related to Pain Relief 2AMT: Glybera(R) Lowers Pancreatitis Incidence Significantly 2AMT: Glybera(R) Lowers Pancreatitis Incidence Significantly 3
Used to negotiate tortuous vessels....
BiodivYsio stent with biocompatible coating (phosphorylcholine)...
... The CYPHER Sirolimus-eluting Coronary Stent ... drug, called "sirolimus", a controlled-release ... delivery platform. Upon placement, sirolimus ... and impedes the process of ...
PT wires combine the enhanced durability of a linear elastic nitinol distal core and a highly resilient polymer tip. This provides excellent access in difficult cases involving severe tortuosity, tig...
Medicine Products: