Navigation Links
Advanced lung cancer patients see improved, progression-free survival
Date:11/13/2008

Patients with advanced non-small cell lung cancer whose disease has progressed following chemotherapy have a higher rate of tumor shrinkage and a longer interval before cancer progression when bevacizumab is added to standard second-line erlotinib therapy, according to a study presented at the 2008 Chicago Multidisciplinary Symposium in Thoracic Oncology, sponsored by ASTRO, ASCO, IASLC and the University of Chicago.

Bevacizumab in combination with chemotherapy and erlotinib alone have each demonstrated a significant improvement in survival when used for the treatment of patients with advanced non-small cell lung cancer. Researchers in this phase III, multicenter clinical trial were hopeful that the combination of the two agents that target different pathways would show a survival benefit.

Six hundred and thirty six patients were enrolled in the study between June 2005 and April 2008. All patients received erlotinib combined with either bevacizumab or a placebo. Neither the patients nor their doctors knew whether they were receiving bevacizumab or the placebo. The final analysis was conducted after 418 deaths.

The study found that the addition of bevacizumab to erlotinib did not improve overall survival compared to erlotinib and placebo. However, there was clear evidence of clinical activity with improvements in progression-free survival and response rate when bevacizumab was added to erlotinib compared to erlotinib alone.

"Bevacizumab and erlotinib are active agents in the treatment of advanced NSCLC. Together they improve progression free survival of patients with recurrent advanced NSCLC," said John Hainsworth, M.D., lead author on this study and chief scientific officer at the Sarah Cannon Research Institute in Nashville. "We remain committed to exploring how survival can be improved using these agents."


'/>"/>

Contact: Beth Bukata
bethb@astro.org
703-839-7332
American Society for Therapeutic Radiology and Oncology
Source:Eurekalert

Page: 1

Related medicine news :

1. Advanced Imaging Technologies to Limit Breast and GI Biopsy Procedures
2. Unilens Launches New C-VUE(R) Advanced(TM) Custom Toric Lens
3. Philips Introduces New, Advanced Light Therapy Device to Offer Quick Relief from Winter Blues
4. Many Breast Cancer Patients Are Not Receiving Most Advanced Breast Conserving Surgical Techniques, New Study Finds
5. Top Indian Cancer Hospital to Introduce Advanced Radiosurgery Treatments With Novalis Tx from Varian Medical Systems and BrainLAB
6. Advanced Health Care Options for People With Diabetes
7. Doctors Test Advanced Tool for Treating Prostate Cancer
8. Relations PR & Marketing Named Agency of Record for Advanced Ultrasound Services
9. Glycotex Finalizes Collaboration Agreement with Advanced Medical Solutions
10. Advanced Circulatory Systems Receives $1.5 Million From NIH for Study of Cardiac Arrest Resuscitation Techniques
11. Advanced Life Sciences and Wyeth Sign Commercialization Agreement for Cethromycin in Asia Pacific Region
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2017)... (PRWEB) , ... July 25, 2017 , ... SignatureCare Emergency ... in the Austin, TX area 24 Hours a day. , The Emergency ... TX. , “We’ve been open four months now and things are running smoothly,” ...
(Date:7/24/2017)... Angeles, CA (PRWEB) , ... July 24, 2017 , ... ... will spotlight doctors and the cosmetic surgeries they perform on a daily basis. ... performing the cosmetic surgery procedures they specialize in at their practices. , When ...
(Date:7/24/2017)... ... 24, 2017 , ... The International Essential Tremor Foundation (IETF) will host a ... (ET). The seminar will take place on Saturday, Aug. 26 at the Embassy Suites ... will run from 9 a.m. to 12 p.m., with check-in beginning at 8 a.m. ...
(Date:7/24/2017)... (PRWEB) , ... July 24, 2017 , ... A CDC study shows that, although people ... of Caucasians (ages 18 to 29), had at least one case of sunburn within the ... time, which causes people to ignore the issue. However, only recently have people become conscientious ...
(Date:7/24/2017)... Atlanta, Georgia (PRWEB) , ... July 24, 2017 ... ... first comprehensive sleep management solution focused on delivering end-to-end sleep health ... (OSA) program. , Recent literature shows that adherence rates for positive airway pressure ...
Breaking Medicine News(10 mins):
(Date:7/20/2017)... 2017  Prime Therapeutics LLC (Prime) released this statement from ... today,s Institute for Clinical and Economic Review,s (ICER) public ... and value of abuse-deterrent formulations (ADF) of opioids. Prime was ... the meeting. "The ... to the use of abuse-deterrent formulations (ADF) in opioids in ...
(Date:7/15/2017)... 15, 2017 Enterin Inc., a Philadelphia ... disease (PD), today announced the completion of a $12.7 million ... Ventures III, as well as the participation of existing investors. ... to have the support of New Ventures III and our ... validation of the potential of our platform technology to transform ...
(Date:7/13/2017)... Medical Products, a leader in medical product innovation and global patient ... for hospice patient care. ... Centurion Medical Products ... pain management and emotional comfort are part of a hospice,s primary ... preventing unneeded emergency department admission due to severe fecal impaction. One ...
Breaking Medicine Technology: