Navigation Links
Advanced blood analysis may speed diagnosis of heart attacks
Date:9/9/2008

technique called septal ablation pioneered by Michael Fifer, MD, of MGH Cardiology that destroys the excess tissue, a scenario that mimics the damage that happens to heart muscle when its blood supply is cut off. Taking blood samples before and after patients receive this procedure provides a unique window into metabolic changes that occur in response to the death of myocardial tissue, allowing study participants to act as their own controls.

The researchers analyzed blood samples from 36 patients taken before and at several time points after septal ablation. Using an advanced mass spectrometry system that can assess hundreds of metabolites in as little as 10 minutes, they were able to identify several that significantly changed right after the ablation process, a time period during which currently available markers remained unchanged. The changes seen in the first 10 minutes persisted an hour later, and analysis of blood from veins in the coronary circulation confirmed that the heart was the source of the changes.

Comparing the results of these 'planned' heart attacks with blood samples from patients with spontaneous coronary blockages found four metabolites that increased in response to ablation and also were elevated in patients with true heart attacks, confirming them as markers of myocardial damage. The researchers also examined whether these newly identified metabolites had any effect on the response of cultured animal heart cells to reduced oxygen and found that one metabolite increased cell death, while two others decreased it, possibly identifying a pathway for future therapies.

"This work is proof of principle that this new technology will work for diagnosis and may also help us find new targets for therapeutic intervention. Someday we may be able to reverse the damage from a heart attack with a 'cocktail' of protective metabolites," explains Gerszten, who is an associate professor of Medicine at Harvard Medical Scho
'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Survival differences by race most apparent in advanced stages of breast cancer
2. Patients with Medicaid and those lacking insurance have higher risk of advanced laryngeal cancer
3. Advanced Age No Bar to Liver Transplant
4. Oncologists are critical in managing psychiatric disorders in patients with advanced cancer
5. Advanced technologies aim to transform the coaching of top athletes
6. Mecklenburg EMS Introduces Most-Advanced Situational Training in America for Emergency Medical Personnel
7. Advanced Life Sciences Joins NASDAQ Capital Market
8. Experimental drug shows promise in advanced kidney cancer
9. TCS Healthcare Technologies Announces Full Integration of Case Management Adherence Guidelines into Acuity Advanced Care(TM) System
10. OCuSOFT Refutes Comparison Time-Kill Study Released by Advanced Vision Research
11. U.S. Oncology Initiates Complete Phase Ib Trial of Brostallicin Combination Therapy in Advanced Solid Tumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2015)... Thermage was the first to come out with a non-surgical ... with the release of NXT or CPT, the second-generation of ... the first practice in New York to debut the new ... had never been achieved before non-surgically. Even today, almost ... many as the leading skin tightening device. The ...
(Date:5/27/2015)... 2015 Western University of Health Sciences’ ... historic firsts -- and one profound last. , The ... marked the first time the university surpassed more than ... Graduate College of Biomedical Sciences (GCBS) alumnus graduated from ... , The university’s fifth and final ceremony of its ...
(Date:5/27/2015)... BBB Code of Business Practices represents sound advertising, selling ... confidence in business. The Code is built on the ... elements of creating and maintaining trust in business. This ... Businesses based in the United States and Canada that ... accredited by BBB. , To be accredited by the ...
(Date:5/27/2015)... Continuing its commitment to finding a cure and ... SmartPractice® donated $25,000 to HonorHealth Breast Health ... President of Human Resources Meg Mosher and SmartScrubs Director ... Paulla Miller, Sherry Gage, Dr. Linda Greer and Ginger ... April 30. The center is located at 19646 North ...
(Date:5/27/2015)... Allred Dental located in San Marcos, CA ... need extensive dental treatment - understand the oral issues they ... their problems. , Dr. Jeff Allred calls it “Dental Case ... assessment of the patient’s oral health and problems together with ... oral health problems. , “The dental case planning process starts ...
Breaking Medicine News(10 mins):Health News:Non-Surgical Fat Reduction and Skin Tightening Procedures, Thermage and Exilis, Increase 200% at Precision Aesthetics in New York, April 2015 2Health News:WesternU Commencement Celebrates Achievements of Graduates and Founding President 2Health News:WesternU Commencement Celebrates Achievements of Graduates and Founding President 3Health News:WesternU Commencement Celebrates Achievements of Graduates and Founding President 4Health News:WesternU Commencement Celebrates Achievements of Graduates and Founding President 5Health News:Carson Energy Receives A+ Accredited Rating For 19 Consecutive Years 2Health News:SmartPractice Donates $25,000 to HonorHealth Breast Health and Research Center 2Health News:San Marcos Dentistry Office Offering a New Service Dental Case Planning 2
... a,statement from Henrietta H. Fore, USAID Administrator:, ... World AIDS,Day and the more than 33 million ... President,s Emergency Plan for AIDS Relief (PEPFAR),the U.S. ... the disease, as well as those dedicated individuals ...
... WHEATON, Ill., Nov. 30 The United States,Golf Association ... in Wheaton, Illinois, to support Marianjoy,s,Therapeutic Golf Program and ... with disabilities., "For over 10 years, the USGA ... persons with disabilities," said Ed Stevenson, a PGA Golf ...
... WASHINGTON, Nov. 30 Today,s New York Times,story on ... therapy,and the critical role it plays in keeping some ... manage the effects of debilitating,and irreversible lung disease., ... it is,nothing more than the rental of inert equipment, ...
... with increasing demands, new technologies, subcommittee finds , , FRIDAY, ... a U.S. Food and Drug Administration subcommittee says the ... and drug supply. , The Subcommittee on Science and ... it says has not kept pace with increasing demands ...
... nano-scale voltmeter developed at the University of Michigan is ... It may someday help researchers tackle such tricky medical ... and how damaged nerves might be mended. , U-M ... a special session, "Creating Next Generation Nano Tools for ...
... slowed respiratory decline by almost a third, study found ... pain reliever and anti-inflammatory ibuprofen significantly slows the decline ... U.S. researchers report. , A team at Case Western ... children with cystic fibrosis who took high doses of ...
Cached Medicine News:Health News:On World AIDS Day, Keeping the Promise to Stop AIDS Through the Power of Partnerships 2Health News:Marianjoy Rehabilitation Hospital Therapeutic Golf Program Receives a $20,000 Matching Grant From the USGA 2Health News:CQRC Statement on the NY Times Article on Medicare's Home Oxygen Benefit 2Health News:CQRC Statement on the NY Times Article on Medicare's Home Oxygen Benefit 3Health News:CQRC Statement on the NY Times Article on Medicare's Home Oxygen Benefit 4Health News:FDA Report Says Nation's Health at Risk 2Health News:FDA Report Says Nation's Health at Risk 3Health News:FDA Report Says Nation's Health at Risk 4Health News:Nano-sized voltmeter measures electric fields deep within cells 2Health News:Nano-sized voltmeter measures electric fields deep within cells 3Health News:Ibuprofen Preserves Lung Function in Kids With Cystic Fibrosis 2Health News:Ibuprofen Preserves Lung Function in Kids With Cystic Fibrosis 3
(Date:5/27/2015)... 27, 2015 ... announced the addition of the  "2015 ... Tactics, and Technological Know How"  report ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , , ,This report ... the orthopedics market, including forecasts for ...
(Date:5/27/2015)... N.H. , May 27, 2015  Frisbie ... (ACR) Accreditation renewal in CT scanning for adult ... radiology have been granted ACR Accreditation: CT, Ultrasound, ... gold seal of accreditation represents the highest level ... and medical physicists who are experts in the ...
(Date:5/27/2015)... Research and Markets ( ... the  "2015 Strategies in the European Hemostasis ... offering.       (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ... pages, 120 tables, and is designed to ... identify and evaluate business opportunities emerging in ...
Breaking Medicine Technology:Global Orthopedics Market 2015: Leading Supplier Strategies, Marketing Tactics, and Technological Know How 2European Hemostasis Diagnostic Testing Market Strategies 2015 2
Inquire...
Adjustable speed vortex with inter-changeable heads, 110 V...
Use the Mo Bio Vortex adapter to process multiple samples at the same time. The adapter holds tubes horizontally to increase cell lysis and mixing efficiency. Ideal for bead beating procedures....
... in conjunction with the Vortex Genie 2 for ... Bio Vortex Adapter is an inexpensive alternative to ... offer the same technology. This particular adapter ... time and will fit any Vortex Genie 2 ...
Medicine Products: