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Advanced Life Sciences' Restanza Demonstrates Efficacy in Treating Anthrax Infection
Date:8/31/2009

CHICAGO, Aug. 31 /PRNewswire-FirstCall/ -- Advanced Life Sciences Holdings, Inc. (OTC Bulletin Board: ADLS), today announced positive results from an animal study involving its novel, once-a-day, oral antibiotic Restanza(TM) (cethromycin) that was conducted to measure Restanza's therapeutic efficacy in treating inhalation anthrax after symptoms of infection had developed. The results of the placebo-controlled non-human primate study showed that a 14-day course of Restanza achieved up to a 60% survival rate when administered after animals demonstrated clinical symptoms of anthrax infection as a result of an inhaled dose of aerosolized anthrax spores that was 200 times the median lethal dose of anthrax. None of the animals that received placebo survived. Due to the extreme lethality of anthrax infection once symptoms appear, Restanza's ability to achieve a 60% survival rate is clinically and statistically significant. The study was supported by the National Institute of Allergy and Infectious Diseases (NIAID), an institute of the National Institutes of Health (NIH), which is a component of the Department of Health and Human Services (HHS), an agency of the U.S. Government.

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Today, there are no approved antibiotics for therapeutic treatment of anthrax infection, and the only approved drugs are administered for post-exposure prophylaxis before the onset of symptoms. In the event of an inhalation anthrax attack, victims may not be aware that they are infected with anthrax until symptoms of anthrax are present. The initial clinical signs and symptoms are nonspecific and may include malaise, headache, fever, nausea, and vomiting and are followed by a sudden onset of respiratory distress and chest pain. The onset of r
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SOURCE Advanced Life Sciences Holdings, Inc.
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