Navigation Links
Advanced Heart Failure Still Kills 1 in 3 Within Three Years: Study

THURSDAY, May 30 (HealthDay News) -- Patients with advanced heart failure have much better survival odds today than 20 years ago, but one in three still dies within three years of their diagnosis, researchers report.

"We are doing a good job of ensuring that patients receive the latest therapies for heart failure, but we still have a lot more work to do," study senior author Dr. Tamara Horwich, an assistant professor of cardiology at the University of California, Los Angeles, David Geffen School of Medicine, said in a UCLA news release.

"It is very sobering that despite recent improvements, a third of advanced heart-failure patients aren't surviving past three years," Horwich added.

In people with heart failure, the heart can't effectively pump blood to the rest of the body. The increasingly common condition affects almost 6 million people in the United States.

For the study, published in the May issue of Circulation: Heart Failure, the researchers examined outcomes in more than 2,500 adults diagnosed with "heart failure with reduced ejection fraction," which is characterized by a weak heart muscle.

The patients were divided into three groups based on when they were treated: 1993 through 1998; 1999 through 2004; and 2005 through 2010. The researchers followed the patients for three years after they were diagnosed.

The study revealed dramatic differences. Patients treated from 1999 on were more likely to receive life-extending drugs, such as beta-blockers and aldosterone antagonists, as well as devices to help stabilize irregular heart rhythms, such as implantable cardioverter defibrillators. Whereas just 15.5 percent of patients used beta-blockers from 1993 to 1998, more than 87 percent used them between 2005 and 2010, the study pointed out.

The increased use of these treatments coincided with publication of the results of clinical trials, and the development of treatment guidelines, the researchers noted.

Prevalence of sudden cardiac death has also decreased, the study showed. At the three-year follow-up point, sudden death declined from 10.1 percent between 1993 and 1998 to 4.6 percent between 2005 and 2010.

Overall mortality rates also decreased over the course of the study. After taking risk factors such as age and gender into account, the investigators found that patients treated between 2005 and 2010 were 42 percent less likely than those in the earliest treatment group to die from any cause.

People who may have died suddenly in the past are living longer thanks to widespread use of implantable cardioverter defibrillators, the authors noted. This trend may be one reason why a shift occurred in the manner of death over the course of the study.

The researchers found patient mortality from progressive heart failure increased from 11.6 percent between 1993 and 1998 to nearly 20 percent between 2005 and 2010. The need for emergency heart transplants also increased over time.

Many of those patients would have died sooner in the earlier eras, said study author Dr. Gregg Fonarow, a UCLA professor of cardiovascular medicine and science.

"For patients with the most advanced heart failure, treatment options used to be limited to heart transplantation -- or face early death," Fonarow said in the news release.

"This study demonstrates that with improvements in medical therapy and availability of implanted devices, survival for these patients has improved considerably. What was once considered an end-stage, terminal disease state has, through implementation of innovative treatments, evolved into a manageable, but still challenging, condition," he explained.

However, more studies are still needed to explore new treatments for heart failure patients, the researchers added.

More information

The U.S. National Heart, Lung, and Blood Institute has more about heart failure.

-- Mary Elizabeth Dallas

SOURCE: University of California, Los Angeles, news release, May 23, 2013

Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Experimental Gel May Help Those With Advanced Parkinsons
2. Advanced genetic screening method may speed vaccine development
3. Advanced Prostate Cancer Drug May Help at Earlier Stage
4. Obese More Likely to Be Diagnosed With Advanced Thyroid Cancer
5. GW researchers discover biomarker for advanced bile duct fibrosis and bile duct cancer
6. San Francisco’s Advanced Male Medical Center Announces Discount, Discusses Erectile Dysfunction
7. Advanced Osteoarthritis Of The Knee Is Now Being Treated With Regenerative Medicine At The Center For Regenerative Medicine
8. Ecig Advanced Sponsors Lexington's First Annual Vaping Event
9. Lack of insurance linked to advanced stage cervical cancer
10. Clinical trial seeks to cure advanced Crohns disease using bone marrow transplant
11. Imaging Tests Up Among Advanced Cancer Patients
Post Your Comments:
Related Image:
Advanced Heart Failure Still Kills 1 in 3 Within Three Years: Study
(Date:10/13/2015)... Angeles, CA (PRWEB) , ... October 13, 2015 , ... ... To incentivize would-be customers, eMarketing Concepts began a $1 promotion – effectively offering all ... a resounding success, and within weeks the company was flooded with phone calls from ...
(Date:10/13/2015)... ... , ... The Bill Howe Family of Companies is an award winning HVAC ... remediation services. Family-owned and operated for 35 years, they have maintained value, ethics and ... two years in a row from the Union Tribune Reader’s Poll, a Healthiest Company ...
(Date:10/12/2015)... ... 2015 , ... Heroes in Recovery (HIR) is proud to ... Network’s Moments of Change conference in West Palm Beach, Florida. Rob Waggener, CEO ... Dauphinais who exemplify the ideals of the Heroes in Recovery movement. , Noah ...
(Date:10/12/2015)... , ... October 12, 2015 , ... Kevin Costello, winner of the “Check-In and Win ... embarks today for his dream vacation to Hawaii. , “I didn’t believe I could win ... says. “This contest encouraged me to get to the gym and invest in my own ...
(Date:10/12/2015)... ... 12, 2015 , ... The American Society of Clinical Hypnosis ... education and clinical training in a health care discipline. , Many practitioners ... as: losing weight, managing pain, or stopping smoking, etc. Frequently, extravagant statements and ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... 2015  Asterias Biotherapeutics, Inc. (NYSE MKT: AST), ... Therapy Catapult to advance development of large scale ... immunotherapy. Under the agreement, the Cell Therapy Catapult ... to support advanced clinical trials and eventual commercialization ... --> The Cell Therapy Catapult is a ...
(Date:10/12/2015)... WASHINGTON , Oct. 12, 2015  Former White House ... Press Secretary for the House Narcotics Committee, Robert Weiner ... "Rewriting Drug Policy." The two emphasize that this is now ... Clinton to Jeb Bush , Carly Fiorina ... Sordello cite the newest federal statistics, which they call "a ...
(Date:10/12/2015)... -- MiMedx Group, Inc. (NASDAQ: MDXG ), the leading ... processes to develop and market advanced products and therapies ... Ophthalmic, and the Dental sectors of healthcare, announced today ... 2015, its guidance for the fourth quarter of 2015, ... Senior Secured Credit Facility. --> ...
Breaking Medicine Technology: