Navigation Links
Advanced Heart Failure Still Kills 1 in 3 Within Three Years: Study
Date:5/30/2013

THURSDAY, May 30 (HealthDay News) -- Patients with advanced heart failure have much better survival odds today than 20 years ago, but one in three still dies within three years of their diagnosis, researchers report.

"We are doing a good job of ensuring that patients receive the latest therapies for heart failure, but we still have a lot more work to do," study senior author Dr. Tamara Horwich, an assistant professor of cardiology at the University of California, Los Angeles, David Geffen School of Medicine, said in a UCLA news release.

"It is very sobering that despite recent improvements, a third of advanced heart-failure patients aren't surviving past three years," Horwich added.

In people with heart failure, the heart can't effectively pump blood to the rest of the body. The increasingly common condition affects almost 6 million people in the United States.

For the study, published in the May issue of Circulation: Heart Failure, the researchers examined outcomes in more than 2,500 adults diagnosed with "heart failure with reduced ejection fraction," which is characterized by a weak heart muscle.

The patients were divided into three groups based on when they were treated: 1993 through 1998; 1999 through 2004; and 2005 through 2010. The researchers followed the patients for three years after they were diagnosed.

The study revealed dramatic differences. Patients treated from 1999 on were more likely to receive life-extending drugs, such as beta-blockers and aldosterone antagonists, as well as devices to help stabilize irregular heart rhythms, such as implantable cardioverter defibrillators. Whereas just 15.5 percent of patients used beta-blockers from 1993 to 1998, more than 87 percent used them between 2005 and 2010, the study pointed out.

The increased use of these treatments coincided with publication of the results of clinical trials, and the development of treatment guidelines, the researchers noted.

Prevalence of sudden cardiac death has also decreased, the study showed. At the three-year follow-up point, sudden death declined from 10.1 percent between 1993 and 1998 to 4.6 percent between 2005 and 2010.

Overall mortality rates also decreased over the course of the study. After taking risk factors such as age and gender into account, the investigators found that patients treated between 2005 and 2010 were 42 percent less likely than those in the earliest treatment group to die from any cause.

People who may have died suddenly in the past are living longer thanks to widespread use of implantable cardioverter defibrillators, the authors noted. This trend may be one reason why a shift occurred in the manner of death over the course of the study.

The researchers found patient mortality from progressive heart failure increased from 11.6 percent between 1993 and 1998 to nearly 20 percent between 2005 and 2010. The need for emergency heart transplants also increased over time.

Many of those patients would have died sooner in the earlier eras, said study author Dr. Gregg Fonarow, a UCLA professor of cardiovascular medicine and science.

"For patients with the most advanced heart failure, treatment options used to be limited to heart transplantation -- or face early death," Fonarow said in the news release.

"This study demonstrates that with improvements in medical therapy and availability of implanted devices, survival for these patients has improved considerably. What was once considered an end-stage, terminal disease state has, through implementation of innovative treatments, evolved into a manageable, but still challenging, condition," he explained.

However, more studies are still needed to explore new treatments for heart failure patients, the researchers added.

More information

The U.S. National Heart, Lung, and Blood Institute has more about heart failure.

-- Mary Elizabeth Dallas

SOURCE: University of California, Los Angeles, news release, May 23, 2013


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Experimental Gel May Help Those With Advanced Parkinsons
2. Advanced genetic screening method may speed vaccine development
3. Advanced Prostate Cancer Drug May Help at Earlier Stage
4. Obese More Likely to Be Diagnosed With Advanced Thyroid Cancer
5. GW researchers discover biomarker for advanced bile duct fibrosis and bile duct cancer
6. San Francisco’s Advanced Male Medical Center Announces Discount, Discusses Erectile Dysfunction
7. Advanced Osteoarthritis Of The Knee Is Now Being Treated With Regenerative Medicine At The Center For Regenerative Medicine
8. Ecig Advanced Sponsors Lexington's First Annual Vaping Event
9. Lack of insurance linked to advanced stage cervical cancer
10. Clinical trial seeks to cure advanced Crohns disease using bone marrow transplant
11. Imaging Tests Up Among Advanced Cancer Patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Advanced Heart Failure Still Kills 1 in 3 Within Three Years: Study
(Date:10/13/2017)... ... October 13, 2017 , ... The International Association ... standards of excellence for the field of eating disorders, announces the opening of ... 2018 in Orlando, Florida at the Omni Resort at ChampionsGate. , ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Lori R. ... a member of ElderCounsel, a national organization of elder law and special needs planning ... laws and rules. It also provides a forum to network with elder law attorneys ...
(Date:10/13/2017)... ... ... The Visiting Nurse Association (VNA) of Somerset Hills is proud to host ... items from across the nation, this holiday-themed event will raise funds and awareness for ... The boutique will be open Saturday, November 4 (10:00 a.m. – 5:00 p.m.) ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer ... one of the most popular and least understood books in the Holy Scriptures, Revelation. ... descriptions that have baffled scholars for centuries. Many have tossed it off as mere ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to ... to save lost souls in the Philippines. “The Journey: From the Mountains to the ... teacher of the Bible. She has taught all ages and currently teaches a class ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... , Oct. 12, 2017 West Pharmaceutical ... innovative solutions for injectable drug administration, today announced that ... market opens on Thursday, October 26, 2017, and will ... and business expectations at 9:00 a.m. Eastern Time. To ... 253-336-8738 (International). The conference ID is 94093362. ...
(Date:10/11/2017)... , Oct. 11, 2017  True Health, a ... amplified its effort during National Breast Cancer Awareness ... cancer risks. ... Oncology calculated that more than 10 million American ... mutations in BRCA1 or BRCA2 and have not had ...
(Date:10/10/2017)... --  West Pharmaceutical Services, Inc. (NYSE: WST), a ... today shared the results of a study highlighting the ... administration of polio vaccines. The study results were presented ... by Dr. Ondrej Mach , Clinical Trials and ... and recently published in the journal Vaccine. i ...
Breaking Medicine Technology: