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Advance in using biopsy samples in understanding environmental causes of cancer
Date:9/9/2013

local diet, contaminated with Aristolochia sp. Using the new mass spectrometric approach, Turesky and Yun verified the existence of DNA adducts involving aristolochic acid in patients with upper urinary tract cancer, further strengthening the link between this chemical and upper urinary tract cancer.

"With this method, we can retrieve DNA adducts from FFPE samples and, in effect, use them as a dosimeter to measure human exposure to suspected carcinogens," said Yun. "The exposure to chemicals and their DNA adducts may be correlated to mutations in specific genes that can lead to cancer in a patient, and point to specific environmental agents carcinogens and suspected carcinogens. The methodology will be of major importance in understanding exposures and the role of chemicals in the environment in causing cancer."

Turesky and Yun now are checking FFPE samples for DNA adducts associated with cigarette smoking, cooked meats and air pollution.


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Contact: Michael Bernstein
m_bernstein@acs.org
317-262-5907 (Indianapolis Press Center, Sept. 6-11)
202-872-6042

Michael Woods
m_woods@acs.org
317-262-5907 (Indianapolis Press Center, Sept. 6-11)
202-872-6293

American Chemical Society
Source:Eurekalert


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