Navigation Links
Advance in using biopsy samples in understanding environmental causes of cancer
Date:9/9/2013

ture without spoiling. By some estimates, more than 1 billion such FFPE samples are archived around the world, containing a wealth of information that scientists have begun to use in various kinds of research.

Yun explained that scientists who study human exposure to potential cancer-causing substances in the environment long have dreamed of using FFPE samples to look for the tell-tale signs of such exposure. Those biomarkers are "DNA adducts," pieces of DNA where a carcinogenic substance has latched on. The bonding may mean the start of cancer.

"But the only available way of processing those samples to detect DNA adducts had serious drawbacks," said Yun. "It required the use of harsh conditions that caused the DNA to decompose, and the technique had serious drawbacks in identifying the kind of adduct and determining how much was present. Our experimental breakthrough solves those problems and enables broader use of FFPE samples in understanding the role of environmental exposures in cancer risk."

Turesky and Yun, who conducted this research at the New York State Department of Health and are currently with the University of Minnesota, used the approach to detect DNA adducts involving a carcinogen called aristolochic acid in biopsy samples from patients from the Balkans and Taiwan with upper urinary tract cancer. Found naturally in certain plants of the genus Aristolochia sp., aristolochic acid is present in certain traditional Chinese herbal medicines that have been the subject of health warnings, and the U.S. Food and Drug Administration and regulatory agencies in other countries have banned importation of Aristolochia herbs. Aristolochic acid is also the causal agent of Balkan endemic nephropathy, a devastating environmental disease recently shown to be caused by the ingestion of bread, a major component of the
'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
317-262-5907 (Indianapolis Press Center, Sept. 6-11)
202-872-6042

Michael Woods
m_woods@acs.org
317-262-5907 (Indianapolis Press Center, Sept. 6-11)
202-872-6293

American Chemical Society
Source:Eurekalert


Page: 1 2 3

Related medicine news :

1. Advance Systems Enhances Their Absence Management Software
2. New Way to Track Stem Cell Migration Could Advance Treatments for Brain Tumors and More
3. Advanced Sinus Treatment Available at Kishwaukee Hospital
4. Visioneer and Office Gemini Partner to Offer Production Scanners with Advanced Capture Software
5. Mirena IUD Lawsuit Help: Resource4thePeople Reports Number of Consolidated Cases Increases as Litigation Advances
6. 21st Century Oncology to Advance Cancer Research with University Partnership
7. Advanced Skin & Hair Inc. Launches the Latest in Anti-Aging Technology: RejuveMD Tinted Anti-Aging SPF 30
8. Find Urgent Care, LLC Announces a Change in Their Directory Pricing Model For "Advance Listings" From Traditional Monthly Fees to Pay-Per-Click
9. Continuing Education and Certificate of Advanced Achievement in Kinesiology for Health, Fitness and Wellness Professionals Now Available from Wexford University Online
10. Nutrition Science for Fitness and Wellness Professionals Certificate of Advanced Achievement Now Available from Wexford University
11. New Web Based Conservation Storefront Will Offer Hard to Find Advanced Efficiency Technologies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... Village, IL (PRWEB) August 29, 2014 ... Baty, “The Safety Chick” who profiled a handful ... Safe-Listening Earphones from Etymotic Research. This year, many ... list, and Etymotic, an innovator of hearing wellness ... ears. Their ETY•Kids Safe-Listening Earphones, offered in yellow, ...
(Date:8/29/2014)... Mass. (August 29, 2014, 2 PM US Eastern ... is to inject antibodies, commonly produced in animals, ... challenges ranging from safety to difficulties in developing, ... , New research led by Charles Shoemaker, ... and Global Health at the Cummings School of ...
(Date:8/29/2014)... 2014 The microbiology testing sector is ... diagnostics industry; it is also the hugest challenge facing ... the ongoing spread of AIDS – still the world’s ... the upsurge of opportunistic infections (OIs); bioterrorism threat; advancements ... of immunosuppressive medicines. Although for certain infections the etiology ...
(Date:8/29/2014)... News) -- Prostate cancer patients lacking knowledge about the ... lead to worse quality of care and long-term results, ... with a median age of 63. All were newly ... the disease was associated with greater difficulty deciding which ... would be effective, the study found. "For prostate ...
(Date:8/29/2014)... 2014 Edvance360, a leading provider of ... online teaching, as well as 2011 winner and six-time-finalist ... Management System, announced that Brooke Education Services, Northwest Academy, ... Interactive Advertising Bureau of Canada (IAB Canada), StarSVCS, and ... are delighted to welcome each new client to the ...
Breaking Medicine News(10 mins):Health News:The Today Show Features ETY•Kids® Safe-Listening Earphones by Etymotic 2Health News:Mice study shows efficacy of new gene therapy approach for toxin exposures 2Health News:Infectious Disease Testing Universe Examined in New VPG Research Report Available at MarketPublishers.com 2Health News:Infectious Disease Testing Universe Examined in New VPG Research Report Available at MarketPublishers.com 3Health News:Faced With Prostate Cancer, It Helps to Know the Enemy 2Health News:Edvance360 Continues to Experience Growth in Corporate, K-12, Health, and Non-Profit Sectors 2
... - Nearly 500 kindergarten schools on the island ... , from the eastern Malaysian state of Sarawak// succumbed to ... reports from the official news agency today. ,Health ... ordered immediate closure of 488 schools for two weeks, with ...
... Wales have discovered that temporary injury to the ... lead to chronic fatigue syndrome (CFS). ,More ... the brain that play a critical role in the ... infection could damage the above-mentioned regions of the brain. ...
... centres have been blamed for interfering in the approach ... the where and when// of patient surgery, serve as ... the British Medical Association feel that the inference lead ... referral management centres are currently being managed by staff ...
... virtual reality simulation tools are making dentists hone their ... Cenk Cavusoglu has his // way, then this method ... delicate surgeries in a risk-free manner. ,"Simulation ... learning time and allows students to learn independently," said ...
... scientists in Victoria have claimed that they have developed ... ,These two viruses in question can easily kill humans ... charge sheet against the viruses is that Hendra virus ... Rail and 16 horses in Brisbane. Thereafter the trainer ...
... German study has now proved that acupuncture, even sham acupuncture ... treating migraine//. A comparable level of treatment efficacy has been ... obtained with respect to reduction in migraine days. ... included for the study. The study participants who had two ...
Cached Medicine News:Health News:Brain Injury, A Consequence Of Glandular Fever Could Trigger Fatigue Syndrome 2Health News:Referral Schemes Blamed By GPs For Treatment Delay 2
(Date:8/29/2014)... -- Research and Markets has announced the ... 2014-2017" report to their offering. ... reimbursement for medical expenses, the Chinese orthopedic instrument market ... a CAGR of 19.2% during 2009-2013. Trauma products, spine ... orthopedic instruments in China , of ...
(Date:8/29/2014)... 2014 Research and Markets  has announced the ... 2014" report to their offering. The ... of the largest segments of pharmaceuticals industry. The numbers of ... available therapies were unable to meet the market requirements. There ... CNS disorder, especially over the past two decades. The market ...
(Date:8/29/2014)... -- Does your doctor know what you,re smoking?  Chances are, ... to the over 112,000 currently registered patients under ... other roughly 20,300+ active physicians listed with the Colorado Dept ... even though a poll in February 2014 showed 51% of ... it. "With marijuana legalization underway, every doctor ...
Breaking Medicine Technology:China Orthopedic Instrument Industry Report, 2014-2017 2US CNS Disorders Drug Pipeline Insight 2014 2Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 2Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 3Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 4
... SAN DIEGO, Oct. 2 Pharmatek Laboratories, Inc., a ... industry, announced that it is the first CRO on ... the company,s preclinical and early phase clinical GMP supply ... move our customers, drug candidates into the clinic more ...
... The next major personalized medicine advances will create therapies that ... health care industry to gain access, the inventor of the ... Medical Center,s Personalized Health Care National Conference ... for Systems Biology, said personalized medicine,s first "killer apps" - ...
Cached Medicine Technology:Pharmatek Laboratories Announces Acquisition of the First Xcelodose(R) 600S System on the West Coast 2Personalized Medicine 'Killer Apps' Will Transform Care Model 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: