Navigation Links
Adult survivors of childhood cancer at risk of becoming frail at an early age
Date:11/18/2013

Young adults who survived childhood cancer are more likely than their peers to be frail, according to a St. Jude Children's Research Hospital study, which reported the condition is more common among female survivors than women decades older. The research appears in the November 18 online edition of the Journal of Clinical Oncology.

Researchers also found that frail health was associated with a greater risk for adult childhood cancer survivors of death and chronic disease. Being frail was defined by the presence of at least three of the following weakness, self-reported exhaustion, physical inactivity, low muscle mass and slow walking speed. In the general population, it is most commonly associated with advancing age.

In this study of 1,922 childhood cancer survivors, 13.1 percent of women and 2.7 percent of men qualified as frail despite having an average age of less than 34 years old. In a comparison group of 341 young adults with an average age of 29 years old and no history of childhood cancer, none qualified as frail. Nationally, an estimated 9.6 percent of women age 65 and older and 5.2 percent of men in the same age group meet the definition. The unexpectedly high prevalence of frailty among childhood cancer survivors suggests accelerated aging, researchers said.

After adjusting for existing chronic health problems, researchers calculated that frail childhood cancer survivors were 2.6 times more likely to die than their non-frail counterparts. The risk was highest for frail male survivors, who were at a six-fold increased risk of death compared to male survivors who were not frail. Frail survivors were also more than twice as likely as survivors who were not frail to develop additional chronic health problems.

"There are steps survivors can take to reduce their risk and improve their fitness," said the study's first and corresponding author Kirsten Ness, Ph.D., an associate member of the St. Jude Department of Epidemiology and Cancer Control. Exercise can reverse frailty in the elderly, and Ness said this study reinforces the need for survivors to work with their health care providers to become more fit.

Ness said quantifying the extent of frailty among childhood cancer survivors will help the medical community recognize and respond to the unique health needs of this growing population, which includes more than 400,000 U.S. residents. St. Jude is working on strategies to prevent or address the condition in this at-risk group.

These results are just the latest findings from the St. Jude Lifetime Cohort Study (St. Jude LIFE). St. Jude LIFE brings the hospital's pediatric cancer survivors back to campus for two to three days of medical testing and assessments. The goal is to better understand and address the challenges facing childhood cancer survivors as they age.

The survivors in this study were treated at St. Jude between 1962 and 2003. At least 10 years had passed since their cancer diagnosis when they joined St. Jude LIFE.

This study found frailty was more common among male survivors who smoked, were underweight and whose pediatric cancer treatment included abdominal or pelvic irradiation. In contrast, lifestyle was not associated with frailty risk in female survivors.

Cranial irradiation was associated with a greater likelihood of frailty in men and women. St. Jude is a pioneer in reducing radiation in treatment of childhood cancer, particularly the most common childhood cancer, acute lymphoblastic leukemia (ALL). Rates of frailty were highest among survivors of central nervous system tumors and other solid tumors, including soft-tissue sarcomas.

Work is underway to better understand frailty in childhood cancer survivors, including how it mirrors or differs from age-related frailty.

For example, in the elderly, muscle weakness appears to precede loss of muscle mass. That differs from childhood cancer survivors, who commonly have less lean muscle mass than Americans of the same age, sex and race. Lean muscle is the skeletal muscle that is the basis of strength and function. Patients experience cancer-related muscle wasting during treatment when nutrition and exercise are also a struggle. The late effects of treatment, including hormonal abnormalities and physical disability, may make it difficult for some survivors to fully recover.


'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert  

Related medicine news :

1. Teens who drink alone more likely to develop alcohol problems as young adults
2. Water is the Top Adult Daily Beverage Choice, But Not So Much for Kids and Teens, Reports NPD
3. Effect of lowering of body temperature for adults with cardiac arrest prior to hospital arrival
4. Regenstrief and IU study: Older adults with severe mental illness challenge healthcare system
5. Home Care Assistance of Vancouver Unveils New and Informative Website Targeting Older Adults is Shaking up the Online Health and Wellness Scene
6. Researchers call for health-care changes to help adults with developmental disabilities
7. Center for Autism and Related Disorders Launches Unique Program to Give Adults with Autism Greater Quality of Life
8. The Becca Foundation Seeks All Teen and Young Adults with Cancer Nonprofits for a Website Link
9. San Antonio Alcohol Rehab Presents New Video Regarding Its Services and Consultations for Adults, Adolescents
10. Avoiding the Hazards of Winter for Older Adults
11. Learning ZoneXpress (LZX) Launches New Product Line Aimed at Educating the Older Adult Market About Health Topics
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Adult survivors of childhood cancer at risk of becoming frail at an early age
(Date:3/24/2017)... Oakland, CA (PRWEB) , ... March 24, 2017 ... ... present on two panels at the Advanced ERISA Benefit Claims Litigation seminar in ... and Creating the Administrative Record, The majority of cases litigated under ERISA involve ...
(Date:3/24/2017)... , ... March 24, 2017 , ... ... first Certified Medical Reiki™ Master in Frederick, MD. Judy says, “I am passionate ... during what is often a very difficult and challenging time.” , A Certified ...
(Date:3/24/2017)... ... March 24, 2017 , ... “The Adventures of Joey, The Dog Who Barks ... lives his life to the fullest, as God intended. “The Adventures of Joey, The ... mother and grandmother pursuing her passion for writing, especially about truth and human behavior. ...
(Date:3/23/2017)... ... March 23, 2017 , ... Texas Physical Therapy Specialists (TexPTS) ... Gruene Road in Building 2. The clinic is the group’s second in New Braunfels ... opening the company’s second New Braunfels location brings things full circle for the group, ...
(Date:3/23/2017)... ... March 23, 2017 , ... Dilger-Maxwell ... of the Norwalk and Vermillion areas, celebrates the newest charity campaign in ... nonprofit, community-based substance abuse prevention and peer recovery support organization providing vital ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... HICKORY, N.C. , March 23, 2017  Transportation ... accolades as an end-to-end supply chain management firm with ... of Consumer Product Solutions Rick Zaffarano was ... Star of the Supply Chain by the only publication ... the global food supply chain. "Rick has ...
(Date:3/23/2017)... 2017 Summary ... pipeline guide Primary Hyperoxaluria - Pipeline Review, H1 ... (Genito Urinary System And Sex Hormones) pipeline landscape. ... by recurrent kidney and bladder stones. It results ... Symptoms include blood in the urine, pain when ...
(Date:3/23/2017)... 23, 2017 Research and Markets has announced ... report to their offering. ... The global oxygen therapy devices market to grow ... The report, Global Oxygen Therapy Devices Market 2017-2021, has been ... experts. The report covers the market landscape and its growth prospects ...
Breaking Medicine Technology: