Navigation Links
Adult stem cell changes underlie rare genetic disease associated with accelerated aging
Date:3/2/2008

Adult stem cells may provide an explanation for the cause of a Hutchinson-Gilford Progeria Syndrome (HGPS), a rare disease that causes premature aging in children, according to researchers at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH). These findings, the first to indicate a biological basis for the clinical features of HGPS, also known as progeria, may also provide new insights into the biological mechanisms of normal aging. The results were published in the March, 2008, issue of Nature Cell Biology.

Studies like this of the biology of HGPS hold the potential to benefit children suffering this terrible illness and enlighten us as to the medical changes we all experience as we grow older. said NCI Director John E. Niederhuber, M.D. As our population ages, we have an increasing need for greater understanding of the biology of aging and age-related illness, such as cancer.

HGPS is an extremely rare hereditary genetic disease of children characterized by signs of premature aging. Children with HGPS generally experience the first symptoms by the age of one, and on average succumb around the age of 15, almost exclusively from premature, progressive heart disease. HGPS occurs in one out of four to eight million births; only 100 patients have been documented in the medical literature. Because its striking cardiovascular effects and other clinical features are so closely associated with the normal aging process, HGPS holds great interest for researchers studying age-related biological changes and disease.

The cause of HGPS, a mutated protein called progerin, was identified in 2003. However, the mechanism by which progerin causes the widespread clinical effects of HGPS has been unclear. To forge this link between molecular biology and medical outcome, Tom Misteli, Ph.D., head of the Cell Biology of Genomes Group at NCIs Center for Cancer Research (CCR), and CCR staff scientist Paola Scaffidi, Ph.D., e
'/>"/>

Contact: NCI Press Officers
ncipressofficers@mail.nih.gov
301-496-6641
NIH/National Cancer Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. YMCA of the USA and McNeil Consumer Healthcare Partner to Promote Health for Older Adults
2. Adult Stem Cells Help Those With Immune Disorders, Heart Disease
3. A rare diagnosis in the operation room: Kidney atrophy due to duplicated colon in an adult
4. Cognitive Impairment Declining in Older Adults
5. CME LLC Offers Education to Help Medical Professionals Better Recognize Adult ADHD
6. Hand-held computers prod older adults to exercise more, Stanford study shows
7. JDRF partners with Plureon to explore generating insulin-producing cells from adult stem cells
8. Modified Atkins diet can cut epileptic seizures in adults
9. Anti-Inflammatory Drug Improves Glycemia, Lowers Inflammation in Obese, Young Adults
10. Teens, Young Adults Missing Out on Latest Cancer Advances
11. Turning on adult stem cells may help repair bone
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... 2014 Natural Clear Vision , a ... his own vision from legally blind to perfect 20/20 vision ... review. , “There is a huge portion of the ... function, and most people just think that’s the way it ... that can be pretty risky at times,” reports Michaels. “This ...
(Date:8/22/2014)... deletion in advanced non-small cell lung cancer (NSCLC) ... in epidermal growth factor receptor (EGFR) tyrosine kinase ... BIM deletion independently predicts overall survival (OS) of ... activate the programmed cell death also known as ... been detected in 12.8% of the Asian population ...
(Date:8/22/2014)... (RA), a complex autoimmune disease that affects 1 ... not only cope with pain, disability and joint ... work, family life and marital functioning. While many ... and disability is common. In addition, some patients ... or side effects. Because of this, there is ...
(Date:8/22/2014)... London, UK (PRWEB) August 22, 2014 ... more magnetic for some clinical applications due to ... of the emerging innovations in ultrasound, such as ... imaging, are expected to keep the market moving ... as increasing mobility can enhance not only the ...
(Date:8/22/2014)... Wisconsin (PRWEB) August 22, 2014 Mueller ... for Plantar Fasciitis, an exciting new product that provides ... you to stay active while you heal. The package ... is truly a new technology – it is not ... , FasciaDerm® PFTape™ System for Plantar Fasciitis ...
Breaking Medicine News(10 mins):Health News:Natural Clear Vision: Review Exposes Kevin Richardson’s Program for Restoring Vision Naturally 2Health News:Deletion predicts survival in advanced non-small cell lung cancer 2Health News:Study shows cognitive-behavioral coping skills training has positive effects on rheumatoid arthritis 2Health News:Global Top Ultrasound Market Suppliers Assessed in New VPG Research Report Available at MarketPublishers.com 2Health News:Global Top Ultrasound Market Suppliers Assessed in New VPG Research Report Available at MarketPublishers.com 3Health News:Mueller Introduces FasciaDerm® PFTape™ System for Plantar Fasciitis 2
... BASKING RIDGE, N.J., Oct. 19 Hooper Holmes,Inc. ... a proven, standard,method for acquiring the additional health ... applicants. Mature Assessment reflects the trend of ... increased willingness to insure them.,To address these customers, ...
... Skin Treatment to Treat All ... BARRINGTON, Ill., Oct. 19 Steroids have been in ... must be reasons why,people use steroid products on a regular ... of the human body, and it needs to stay healthy. ...
... Host Conference Call and Webcast Same Afternoon, DENVER, ... of functional foods, beverages and nutritional,supplements, today announced that ... the three and nine months, ended September 30,2007, on ... a teleconference the same afternoon beginning at,4:15 PM Eastern ...
... XI,AN, China, Oct. 19 /Xinhua-PRNewswire-FirstCall/ -- Mr. Weibing ... (OTC,Bulletin Board: SKBI) ("Skystar") will be featured in ... 24, 2007, at 10:30 a.m.,EST. The interview will ... p.m. EST on,October 24. The interview will ...
... drug is given just once per month, experts say , ... treating anemia in patients with severe kidney disease could help ... , Compared with conventional therapy, giving patients an anti-anemia drug ... concluded Dr. Nathan Levin, of the Renal Research Institute in ...
... ... at TCT 2007 ... Oct. 19 Stereotaxis, Inc. (Nasdaq:,STXS) announced today that it will ... at the,Transcatheter Cardiovascular Therapeutics (TCT) symposium in Washington,D.C., October 20 to ...
Cached Medicine News:Health News:Hooper Holmes Introduces Mature Assessment 2Health News:Steroids Are Abused for Skin, Not Just Muscles 2Health News:XELR8 Holdings to Announce 2007 Third Quarter Results on Wednesday, October 31, 2007 2Health News:XELR8 Holdings to Announce 2007 Third Quarter Results on Wednesday, October 31, 2007 3Health News:Skystar Bio-Pharmaceutical Announces Upcoming Interview With WallSt.net ( www.wallst.net ) 2Health News:Simpler Anemia Treatment May Help Kidney Patients 2Health News:Stereotaxis Showcases Interventional Cardiology Capabilities of Niobe Magnetic Navigation System 2Health News:Stereotaxis Showcases Interventional Cardiology Capabilities of Niobe Magnetic Navigation System 3Health News:Stereotaxis Showcases Interventional Cardiology Capabilities of Niobe Magnetic Navigation System 4
(Date:8/21/2014)... 2014   Memorial Hermann Health System and ... announced a new partnership to provide a new level of ... centers in the greater Houston area. ... the exclusive provider of professional breast radiology services for five ... City, The Woodlands , Northeast, Southwest and ...
(Date:8/21/2014)... Aug. 21, 2014 Nektar Therapeutics (NASDAQ: ... today announced positive results from its Phase 3 ... extended half-life recombinant factor VIII (rFVIII) treatment for ... which met its primary endpoint in reducing annualized ... to the on-demand arm. Top-line results ...
(Date:8/21/2014)... , Aug. 21, 2014 The spinal column ... the human body. Signals carried to and from the brain ... skills and nervous system. Injury or ailment here can be ... with a loss of control over their body. Though back ... a person,s life, there are more options available to make ...
Breaking Medicine Technology:Memorial Hermann, MD Anderson join forces to provide enhanced breast imaging services throughout the Greater Houston Region 2Memorial Hermann, MD Anderson join forces to provide enhanced breast imaging services throughout the Greater Houston Region 3Memorial Hermann, MD Anderson join forces to provide enhanced breast imaging services throughout the Greater Houston Region 4Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 2Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 3Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 4Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 5Don't Live in Pain: Four Life Improving Benefits of Back Surgery 2
... CHAPEL HILL, N.C., Sept. 24 As the bio-pharmaceutical ... area of Oncology are tailoring their market education strategies ... their therapeutic area. Leading organizations have found that a ... product launch as KOLs, physicians, and payers in the ...
... WASHINGTON, Sept. 24 OrbusNeich today announced at the ... of patient enrollment in the randomized clinical trial of ... 183 patients included at sites in Asia, Australia, Europe ... this study represents a significant milestone as we look ...
Cached Medicine Technology:Effectively Educating the Marketplace to Support a Successful New Oncology Product Launch 2Patient Enrollment Completed in First Randomized Clinical Study of OrbusNeich's Combo™ Bio-engineered Sirolimus Eluting Stent 2Patient Enrollment Completed in First Randomized Clinical Study of OrbusNeich's Combo™ Bio-engineered Sirolimus Eluting Stent 3
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: