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Adult stem cell application effective in treatment of peripheric vascular disease
Date:1/24/2008

direct improvement of the muscle and a direct enhancement of the vessels.

On the other hand, the study also showed that, although the mononucleate cells are capable of regenerating in the short or medium term, the vascularisation of the mice damaged by the ischemia may have a negative effect in the long term. This is because transplanting mononucleate cells into the limbs of mice generate greater fibrosis with time. This conclusion has given rise to a certain degree of controversy as regards a number of current clinical studies that propose the use of mononucleate cells from bone marrow.

Human MAPCs and those of the mouse

The study was carried out on both cell populations from mice as well as humans. During the research the team from the University Hospital at the University of Navarra and CIMA was responsible for the experiments with human cells, while the University of Leuven team was in charge of the tests with mice cells.

Analysing the results from both models, the same degree of efficacy was observed, to such an extent that the experiments undertaken with MAPCs from mice and those from humans overlap, i.e. they both achieve identical benefits.


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Contact: Egoitz Etxebeste
egoitz@elhuyar.com
Elhuyar Fundazioa
Source:Eurekalert

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