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Adult stem cell application effective in treatment of peripheric vascular disease
Date:1/24/2008

Multipotent adult progenitor stem cells extracted from bone marrow, and known as MAPCs, have proved to be effective in the regeneration of blood vessel tissue and also in muscle tissue when treating peripheric vascular disease. This was the result of research undertaken with mouse models by two research groups, one by the University Hospital of Navarra jointly with the Centre for Applied Medical Research (CIMA), also of the University of Navarra, and the other by the Centre for Molecular and Vascular Biology atthe Catholic University of Leuven (Belgium).

The results of the study have been recently published as an article in The Journal of Clinical Investigation the main author of which is doctor in Biology at the University Hospital of the University of Navarra and CIMA, Xabier Lpez Aranguren. The study was part of a line of research for his PhD thesis. The directors of the current research are doctors Felipe Prsper, for the University Hospital of Navarra and CIMA and Aernout Luttun and Catherine M. Verfaille for the Catholic University of Leuven.

Aim of research

Acute peripheric vascular disease involves the obstruction of the blood circulation in a determined area of the organism, as a consequence of the occlusion of the artery supplying blood to it, with the consequent reduction in blood flow. If it is not treated in time, the ischemia can cause various complications; the worst scenario being tissue necrosis, gangrene, or even the loss of an affected limb. In any case, the basic effect of peripheric ischemia is an important loss of vascularisation in the affected area, as well as in the musculature.

The research work published in The Journal of Clinical Investigation analysed the role and potential of two different types of cell-based treatments for peripheric vascular disease. It was based on the use of experimental mice models that were treated for this blood vessel ailment using MAPC cells implant a
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Contact: Egoitz Etxebeste
egoitz@elhuyar.com
Elhuyar Fundazioa
Source:Eurekalert

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