Navigation Links
Adult offspring of parents with PTSD have lower cortisol levels
Date:9/3/2007

A small study suggests that adults whose parents are Holocaust survivors with post-traumatic stress disorder (PTSD) appear to have lower average levels of the stress hormone cortisol than the adult offspring of parents without PTSD, according to a report in the September issue of Archives of General Psychiatry, one of the JAMA/Archives journals.

Biological differences seen in individuals with PTSD, including low cortisol levels, could either result from exposure to a traumatic event or could be present before such an event and predispose patients to the condition, according to background information in the article. Once identified, such risk factors may prove to be useful as predictors of who will develop PTSD after exposure to trauma, or they may even identify potential new targets for prophylaxis [preventive therapy] and treatment, the authors write.

Rachel Yehuda, Ph.D., of the Mount Sinai School of Medicine and James J. Peters Veterans Affairs Medical Center, Bronx, New York, and colleagues studied 33 individuals whose parents had survived the Holocaust. These study participants were further divided into groups based on whether at least one parent met criteria for PTSD according to a questionnaire completed by the offspring. Twenty-three of the offspring had parents with PTSD, and 10 had parents without PTSD. The researchers measured the participants blood cortisol levels every 30 minutes for a 24-hour period, then compared them with the levels of 16 individuals whose parents were not Holocaust survivors. None of the participants had PTSD at the time of the study.

Individuals whose parents had PTSD displayed lower average cortisol levels over the 24-hour period than did those whose parents did not have PTSD or were not exposed to traumatic events. This decrease seemed specifically related to having a mother with PTSD.

Offspring with parental PTSD also demonstrated changes in some chronobiological parameters previously identified as altered in trauma survivors with PTSD despite that no subject had PTSD at assessment, the authors write. However, the overall pattern of alterations observed in the offspring with parental PTSD did not follow that reported for PTSD, allowing differentiation between parameters associated with risk vs. those associated with PTSD pathogenesis [development].

Although the implications for PTSD prophylaxis cannot be specified from these results, they have clear clinical applications, including assessment of parental PTSD in patients with PTSD and evaluation of stressful events during pregnancy and early childhood, the authors conclude. Indeed, the data suggest that examination of epigenetic [environmental or other effect that does not change DNA] or in utero phenomena should be added to the search for genetic polymorphisms that may underlie individual differences that increase vulnerability to this disorder.


'/>"/>

Contact: Jim Connell
718-584-9000 x6620
JAMA and Archives Journals
Source:Eurekalert

Related medicine news :

1. Overweight children Dont Necessarily Become overweight adults
2. Enzyme stimulates growth of adult stem cells
3. Baby Talk Better Than Adult Speech
4. A question on study of Adult Stem Cell
5. Obesity risk for immobilized adults
6. Adult COPD or asthma could be effectively treated with Xopenex
7. Unfavourable Lipid-Lipoprotein profiles in older adults has been linked to abdominal visceral fat
8. Adult stem cells in treatment for Multiple sclerosis (MS)
9. The Key To Prevention Of Heart Disease In Adults
10. The Harmful Effects Of Stress in Young Adults
11. Abuse in Childhood Could Result In Heart Disease in Adulthood
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... The American Board of Family ... next President and Chief Executive Officer, succeeding Dr. James C. Puffer upon his retirement. ... 1, 2018 until Dr. Puffer’s retirement at the end of 2018. Upon assuming the ...
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton ... staged a mock evacuation of the facility as part of a disaster drill on ... Echo Hose EMS and Shelton City Emergency Manager, as well as the Connecticut ...
(Date:10/13/2017)... ... , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has ... least understood books in the Holy Scriptures, Revelation. The Book of Revelation paints a ... centuries. Many have tossed it off as mere rubbish, but Yisrayl Hawkins says that ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance ... management, will showcase a range of technology and learning solutions at the 68th ... and Expo to be held October 14–18, 2017 at the Mandalay Bay Resort ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical Informatics (ACMI) ... FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s ... Morris F. Collen, a pioneer in the field of medical informatics, this prestigious award ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... -- Halo Labs announces the European launch of their new low ... MIBio 2017 in Cambridge, U.K on October ... biopharmaceutical samples with unprecedented speed and sensitivity while using far less ... Imaging. ... analysis system ...
(Date:9/27/2017)... -- Commended for their devotion to personalized service, SMP Pharmacy Solutions ... in the South Florida Business Journal,s 50 Fastest-Growing Companies, and ... the national specialty pharmacy has found its niche.  To that ... be honored by SFBJ as the 2017 Power Leader in ... receive his award in October, Bardisa said of the three ...
(Date:9/23/2017)... Sept. 22, 2017 Janssen Biotech, Inc. (Janssen) ... letter from the U.S. Food and Drug Administration (FDA) ... sirukumab for the treatment of moderately to severely active ... clinical data are needed to further evaluate the safety ... active RA. ...
Breaking Medicine Technology: