Navigation Links
Adult antiviral drug effective in suppressing hepatitis B in teens
Date:12/5/2012

A recent clinical trial found that the adult antiviral drug, tenofovir disoproxil fumarate (tenofovir DF), is safe and effective in treating adolescents with hepatitis B virus (HBV). Trial results published in the December issue of Hepatology, a journal of the American Association for the Study of Liver Diseases (AASLD), show that tenofovir DF suppressed HBV in 89% of pediatric participants.

Chronic HBV is a major health burden that studies estimate affects 350 million people worldwide, with 600,000 deaths attributed to this chronic disease. The Centers for Disease Control and Prevention (CDC) estimate that more than one million Americans have chronic HBV, with most patients infected during childhood. Medical evidence suggests that 90% of patients infected as infants, and up to 50% infected between one and four years of age develop chronic HBV; 25% of adults who become chronically infected in childhood develop cirrhosis or liver cancer.

"Children chronically infected with HBV are at great risk of developing severe liver disease and possible death due to complications from the disease," said Dr. Karen Murray, Chief of the Division of Gastroenterology and Hepatology at Seattle Children's Hospital in Washington and lead researcher of the clinical trial. "Tenofovir DF is highly effective in treating adults with chronic HBV and our trial evaluated safety and efficacy of the drug in adolescents."

This double-blind, placebo-controlled trial was conducted in 101 adolescents aged 12 to 17 years. Participants were randomized with 52 receiving a daily 300 mg dose of tenofovir DF and 54 taking a placebo for 72 weeks. A virologic responseability of the antiviral medication to suppress the virus in participantswas the main outcome of this clinical trial. At the onset of the trial 91% of participants tested positive for the hepatitis B e-antigen and 85% received prior HBV therapy.

Researchers observed a virologic response in 89%
'/>"/>

Contact: Dawn Peters
sciencenewsroom@wiley.com
781-388-8408
Wiley
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Infection Might Raise Blood Clot Risk for Older Adults: Study
2. EKG Heart Test May Predict Risk in Older Adults
3. Unique approach needed to accurately assess health of young adult cancer survivors
4. Out-of-hand tree nut consumption associated with better diet quality in children and adults
5. Symptomatic behaviour in childhood strongly predicts psychiatric treatment as a young adult
6. Gay Adults Rejected by Parents Have Worse Health, Study Finds
7. Feelings of immaturity accompany alcohol misuse into adulthood; discovery could improve treatments
8. Callahan honored for improving older adults health in their doctors offices
9. Anti-tobacco TV ads help adults stop smoking, study finds
10. Childhood Obesity May Raise Odds of Adult Liver Cancer
11. Better health in adulthood starts with early prevention in childhood
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... Photodynamic therapy (PDT, which uses topical agents and light ... (AKs, a common skin lesion caused by sun damage) ... liquid nitrogen to freeze lesions). , Author: ... Davis Medical Center, in Sacramento, and colleagues. , ... skin typically found on individuals with fair complexions who ...
(Date:8/27/2014)... play a key role in inflaming blood vessels and ... study at UCLA demonstrates that they may also contribute ... the small blood vessels in the lungs. , Using ... mimicking part of the main protein in high-density lipoprotein ... production of oxidized lipids in pulmonary hypertension. They also ...
(Date:8/27/2014)... August 27, 2014 The federal judge ... ) has extended the deadline for plaintiffs to enroll ... 2014 Order issued by U.S. District Judge David Katz ... enroll in the DePuy ASR Settlement Program must do ... Inc. ASR Hip Implant Products Liability Litigation – MDL ...
(Date:8/27/2014)... August 27, 2014 Ticket Down is a ... at Sun Life Stadium in Miami. The Brazilian national ... on September 5 at Sun Life Stadium in Miami Gardens, ... a rematch of the World Cup earlier this year when ... to injury. The Brazilian Soccer Federation announced earlier this week ...
(Date:8/27/2014)... 27, 2014 Connor Sports has ... World Cup in Spain at the Barcelona, Bilbao, Gran ... FIBA Equipment & Venue Centre Partner since 1994 and Official ... six courts will bear the Connor Sports logo and tagline ... globe on the ESPN broadcasts of the FIBA World Cup. ...
Breaking Medicine News(10 mins):Health News:Photodynamic therapy vs. cryotherapy for actinic keratoses 2Health News:Protein in 'good cholesterol' may be a key to treating pulmonary hypertension 2Health News:DePuy ASR Settlement Enrollment Deadline Extended Until September 30, 2014, Bernstein Liebhard LLP Reports 2Health News:DePuy ASR Settlement Enrollment Deadline Extended Until September 30, 2014, Bernstein Liebhard LLP Reports 3Health News:Brazil vs. Colombia Tickets in Miami, FL: Ticket Down Cuts Ticket Prices on World Cup Rematch of Colombia vs. Brazil at Sun Life Stadium in Miami on Sept. 5th 2Health News:Brazil vs. Colombia Tickets in Miami, FL: Ticket Down Cuts Ticket Prices on World Cup Rematch of Colombia vs. Brazil at Sun Life Stadium in Miami on Sept. 5th 3Health News:Connor Sports® Provides Six Custom Courts for 2014 FIBA World Cup - Time-Lapse Video of FIBA Courts Production Released 2Health News:Connor Sports® Provides Six Custom Courts for 2014 FIBA World Cup - Time-Lapse Video of FIBA Courts Production Released 3
... potent antioxidant , FRIDAY, Nov. 13 (HealthDay News) -- ... yellow curry ingredient curcumin, which is being tested in ... and Alzheimer,s disease. , Curcumin, the active ingredient in ... juices in the gastrointestinal tract quickly destroy curcumin, which ...
... one than age, study finds , FRIDAY, Nov. 13 (HealthDay News) ... than in 50-year-old women, according to a study that found that ... The analysis of data from the Million Women Study of 1.3 ... women aged 50 to 54, the risk of hip fracture of ...
... 13 A surprisingly easy and low-cost system of ... with Crohn,s disease and ulcerative colitis, a study released ... an online information network, allowing caregivers to systematically collect ... and their effectiveness. Creation and use of this ...
... Inc. (Nasdaq: BMRN ) announced today that Genzyme ... detected foreign particles in some products filled at the ... not exposed to foreign particles during product administration, Genzyme ... treating patients with enzyme replacement products that it markets, ...
... Nov. 13 Americans may realize that they have a ... underestimate the cost of care, believe government programs cover more ... deal with their own potential care. A national survey of ... of LTC Awareness Month (November) and John Hancock,s "Know Your ...
... for hepatitis and more , FRIDAY, Nov. 13 (HealthDay ... an extensive database about proteins produced by genes in ... the foundation for new treatments for liver disease. , ... kind for any organ, the researchers examined 10 liver-tissue ...
Cached Medicine News:Health News:'Global Bulletin Board' Shows Promise in Child Health 2Health News:'Global Bulletin Board' Shows Promise in Child Health 3Health News:'Global Bulletin Board' Shows Promise in Child Health 4Health News:Particles Detected in Vials from Genzyme's Plant Not Expected to Impact Aldurazyme or Naglazyme 2Health News:Particles Detected in Vials from Genzyme's Plant Not Expected to Impact Aldurazyme or Naglazyme 3Health News:LTC Awareness Month Finds Americans Still in Dark about Long-Term Care 2Health News:LTC Awareness Month Finds Americans Still in Dark about Long-Term Care 3Health News:LTC Awareness Month Finds Americans Still in Dark about Long-Term Care 4Health News:LTC Awareness Month Finds Americans Still in Dark about Long-Term Care 5Health News:LTC Awareness Month Finds Americans Still in Dark about Long-Term Care 6
(Date:8/27/2014)... BOSTON , Aug. 27, 2014  Columbia Laboratories, ... Company"), a provider of pharmaceutical development, clinical trial manufacturing, ... industry, today announced that it will participate at the ... Investment Conference, to be held in New ... conference at 11:15am on September 9, 2014 at the ...
(Date:8/27/2014)... and NINGBO, China , ... the Ningbo Menovo Pharmaceutical Co., Ltd, ("Menovo") today announced ... development of generic pharmaceuticals, primarily targeting the ... the agreement, Amerigen and Menovo will jointly develop products ... States . Menovo will be responsible for manufacturing ...
(Date:8/27/2014)... 2014 /CNW/ - Covalon Technologies Ltd. (the "Company" or "Covalon") ... financial results for its third quarter of fiscal 2014: ... , Revenue of $1,291,378, a 13% decrease over the ... for the quarter of $240,156 compared to net income of ... For the nine months ended June 30, 2014: ...
Breaking Medicine Technology:Amerigen Pharmaceuticals Limited and the Ningbo Menovo Pharmaceutical Co., Ltd, today announced they had entered into a collaboration agreement regarding the development of generic pharmaceuticals, primarily targeting the United States market 2Covalon Announces Third Quarter Results 2Covalon Announces Third Quarter Results 3
... Designs ROM post-operative knee braces are designed ... rehabilitation. , ,Adjustable and versatile, ROM ... for health care professionals. The braces are ... feature quick dial combination hinges that allow ...
... Neuroprene™ soft supports are a convenient, ... proprioceptive taping for common orthopedic conditions/instabilities. ... provide specific compression and lateral to ... (proprioceptors) in the skin and soft ...
... The Deluxe Heavy Duty Drop Lock Post Operative ... pin hinge with a spring loaded drop lock ... arms and contoured plates prevent the brace from ... a tibial offset for anatomical alignment that controls ...
... might just be the world's most versatile ... support, post-op/rehab support, or both, Flex is ... Accutrac™ ROM hinges control flexion and extension ... durability while being heat-moldable to accommodate changes ...
Medicine Products: