Navigation Links
Adult Survivors of Childhood Cancer at Risk of Becoming Frail at an Early Age

Memphis, Tenn. (PRWEB) November 18, 2013

Young adults who survived childhood cancer are more likely than their peers to be frail, according to a St. Jude Children’s Research Hospital study, which reported the condition is more common among female survivors than women decades older. The research appears in the November 18 online edition of the Journal of Clinical Oncology.

Researchers also found that frail health was associated with a greater risk for adult childhood cancer survivors of death and chronic disease. Being frail was defined by the presence of at least three of the following – weakness, self-reported exhaustion, physical inactivity, low muscle mass and slow walking speed. In the general population, it is most commonly associated with advancing age.

In this study of 1,922 childhood cancer survivors, 13.1 percent of women and 2.7 percent of men qualified as frail despite having an average age of less than 34 years old. In a comparison group of 341 young adults with an average age of 29 years old and no history of childhood cancer, none qualified as frail. Nationally, an estimated 9.6 percent of women age 65 and older and 5.2 percent of men in the same age group meet the definition. The unexpectedly high prevalence of frailty among childhood cancer survivors suggests accelerated aging, researchers said.

After adjusting for existing chronic health problems, researchers calculated that frail childhood cancer survivors were 2.6 times more likely to die than their non-frail counterparts. The risk was highest for frail male survivors, who were at a six-fold increased risk of death compared to male survivors who were not frail. Frail survivors were also more than twice as likely as survivors who were not frail to develop additional chronic health problems.

“There are steps survivors can take to reduce their risk and improve their fitness,” said the study’s first and corresponding author Kirsten Ness, Ph.D., an associate member of the St. Jude Department of Epidemiology and Cancer Control. Exercise can reverse frailty in the elderly, and Ness said this study reinforces the need for survivors to work with their health care providers to become more fit.

Ness said quantifying the extent of frailty among childhood cancer survivors will help the medical community recognize and respond to the unique health needs of this growing population, which includes more than 400,000 U.S. residents. St. Jude is working on strategies to prevent or address the condition in this at-risk group.

These results are just the latest findings from the St. Jude Lifetime Cohort Study (St. Jude LIFE). St. Jude LIFE brings the hospital’s pediatric cancer survivors back to campus for two to three days of medical testing and assessments. The goal is to better understand and address the challenges facing childhood cancer survivors as they age.

The survivors in this study were treated at St. Jude between 1962 and 2003. At least 10 years had passed since their cancer diagnosis when they joined St. Jude LIFE.

This study found frailty was more common among male survivors who smoked, were underweight and whose pediatric cancer treatment included abdominal or pelvic irradiation. In contrast, lifestyle was not associated with frailty risk in female survivors.

Cranial irradiation was associated with a greater likelihood of frailty in men and women. St. Jude is a pioneer in reducing radiation in treatment of childhood cancer, particularly the most common childhood cancer, acute lymphoblastic leukemia (ALL). Rates of frailty were highest among survivors of central nervous system tumors and other solid tumors, including soft-tissue sarcomas.

Work is underway to better understand frailty in childhood cancer survivors, including how it mirrors or differs from age-related frailty.

For example, in the elderly, muscle weakness appears to precede loss of muscle mass. That differs from childhood cancer survivors, who commonly have less lean muscle mass than Americans of the same age, sex and race. Lean muscle is the skeletal muscle that is the basis of strength and function. Patients experience cancer-related muscle wasting during treatment when nutrition and exercise are also a struggle. The late effects of treatment, including hormonal abnormalities and physical disability, may make it difficult for some survivors to fully recover.

The paper’s senior author is Melissa Hudson, M.D., a member of the St. Jude Department of Oncology. The other authors are Kevin Krull, Kendra Jones, Daniel Mulrooney, Gregory Armstrong, Daniel Green, Wassim Chemaitilly, Carmen Wilson, Kyla Shelton, Deo Kumar Srivastava and Leslie Robison, all of St. Jude, Webb Smith and Sabeen Ali, both formerly of St. Jude; and Charles Sklar, of Memorial Sloan-Kettering Cancer Center, New York.

The research was funded in part by a grant (CA21765) from the National Cancer Institute at the National Institutes of Health and ALSAC.

Read the full story at

Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related medicine news :

1. Infection Might Raise Blood Clot Risk for Older Adults: Study
2. EKG Heart Test May Predict Risk in Older Adults
3. Unique approach needed to accurately assess health of young adult cancer survivors
4. Out-of-hand tree nut consumption associated with better diet quality in children and adults
5. Symptomatic behaviour in childhood strongly predicts psychiatric treatment as a young adult
6. Gay Adults Rejected by Parents Have Worse Health, Study Finds
7. Feelings of immaturity accompany alcohol misuse into adulthood; discovery could improve treatments
8. Callahan honored for improving older adults health in their doctors offices
9. Anti-tobacco TV ads help adults stop smoking, study finds
10. Childhood Obesity May Raise Odds of Adult Liver Cancer
11. Better health in adulthood starts with early prevention in childhood
Post Your Comments:
(Date:12/1/2015)... , ... December 01, 2015 , ... World Patent ... Multi Jar, a container patent that allows for easier packing and organizing of items ... is worth $90 billion," says Scott Cooper, CEO and Creative Director of World Patent ...
(Date:12/1/2015)... ... December 02, 2015 , ... ... events and association with initiation of treatment for osteoporosis ”. , As corresponding ... pharmacological treatment in patients diagnosed with osteoporosis. Based on a large US managed ...
(Date:12/1/2015)... ... December 01, 2015 , ... Integrated ... acquisition by Jordan Industries International, LLC (“JII”). , With support from JII, Integrated ... maintenance services to hospitals, surgery centers, clinics, research labs and medical facilities across ...
(Date:12/1/2015)... ... 2015 , ... According to an article published on November 16th ... the U.S. Department of Health and Human Services, claiming that any states which do ... the clause in the law prohibiting the denial of coverage for pre-existing conditions. The ...
(Date:12/1/2015)... ... December 01, 2015 , ... Baptist Medical Center ... and is the only hospital in the region providing what is known as ... transcatheter pacing patients were revealed recently at a medical conference and published in ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... , Dec. 1, 2015 As enforcement of ... Chain Security Act (DSCSA) approaches, InfiniTrak ... independent pharmacies comply with looming FDA regulations. ... is entering endorsement agreements with State Pharmacy Associations, ... administration organization (PSAO) to exclusively provide the InfiniTrak ...
(Date:12/1/2015)... ) ... "Spinal Muscular Atrophy Market - Pipeline Assessment, ... 2023" report to their offering. ... addition of the "Spinal Muscular Atrophy ... and Forecast 2015 - 2023" report ...
(Date:12/1/2015)... AMSTERDAM , Dec. 1, 2015 /PRNewswire/ -- ... announced SkyFlow , an X-ray imaging software that ... clinicians decide not to use a grid, at the ... (RSNA) 1 . SkyFlow is Philips, first digital ... for grid-less radiography, which improves clinician,s workflow and supports ...
Breaking Medicine Technology: