Navigation Links
Adult Stem Cells Help Those With Immune Disorders, Heart Disease
Date:2/26/2008

Analysis of studies finds modest benefit with both conditions

TUESDAY, Feb. 26 (HealthDay News) -- Treatment with adult stem cells harvested from blood or bone marrow may benefit some patients with certain kinds of cardiovascular disorders and autoimmune diseases, a new U.S. analysis shows.

There are two types of stem cells, according to background information in the study. Embryonic stem cells are harvested from embryos four to five days after fertilization. Adult stem cells are located in tissues throughout the body and provide a reservoir for replacement of damaged or aging cells.

While stem cell therapy shows great promise, "clinical application has lagged due to ethical concerns [over embryonic stem cells] or difficulties harvesting or safely and efficiently expanding sufficient quantities," the review authors noted. "In contrast, clinical indications for blood-derived [from peripheral or umbilical cord blood] and bone marrow-derived stem cells, which can be easily and safely harvested, are rapidly increasing."

Dr. Richard K. Burt, of the Northwestern University Feinberg School of Medicine, and colleagues examined hundreds of studies of blood- or bone-marrow derived stem cells that were conducted between January 1997 and December 2007 -- 323 assessed feasibility and toxicity, and 69 looked at patient outcomes.

The review found that in 26 studies involving a total of 854 patients with autoimmune diseases there was a treatment-related death rate of: less than 1 percent (two of 220 patients) for nonmyeloablative (not causing bone marrow suppression); less than 2 percent (three of 197 patients) for dose-reduced myeloablative; and 13 percent (13 of 100 patients) for intense myeloablative regimens -- those including total body irradiation or high-dose busulfan, a drug used to treat some forms of chronic leukemia.

"While all trials performed during the inflammatory stage of autoimmune disease suggested that the transplantation of hematopoietic [formation of blood or blood cells] stem cells [HSCs] may have a potent disease-remitting effect, remission duration remains unclear, and no randomized trials have been published," the review authors wrote.

In 17 studies of 1,002 heart attack patients, 16 studies of 493 patients with chronic coronary artery disease, and three meta-analyses, there was evidence suggesting that adult stem cell transplantation may help lead to modest improvements in cardiac function among people with coronary artery disease.

More clinical trials are needed to determine the most appropriate stem cell type, dose, method, timing of delivery -- as well as adverse effects -- to treat cardiovascular and immune diseases and other disorders, the review authors concluded.

The study is published in the Feb. 27 issue of the Journal of the American Medical Association.

More information

The U.S. National Institutes of Health has more about stem cells.



-- Robert Preidt



SOURCE: Journal of the American Medical Association, news release, Feb. 26, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. A rare diagnosis in the operation room: Kidney atrophy due to duplicated colon in an adult
2. Cognitive Impairment Declining in Older Adults
3. CME LLC Offers Education to Help Medical Professionals Better Recognize Adult ADHD
4. Hand-held computers prod older adults to exercise more, Stanford study shows
5. JDRF partners with Plureon to explore generating insulin-producing cells from adult stem cells
6. Modified Atkins diet can cut epileptic seizures in adults
7. Anti-Inflammatory Drug Improves Glycemia, Lowers Inflammation in Obese, Young Adults
8. Teens, Young Adults Missing Out on Latest Cancer Advances
9. Turning on adult stem cells may help repair bone
10. Adult stem cell application effective in treatment of peripheric vascular disease
11. Governor Rendell Offers Coverage to 29,000 on AdultBasic Waiting List; Unveils New Policy to Improve Quality of Care for the Low-Income and Pennsylvanians With Disabilities
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Adult Stem Cells Help Those With Immune Disorders, Heart Disease
(Date:6/25/2017)... ... ... June is Men’s Health Month and the focus is on prostate cancer. Second ... U.S. and the third most common cause of cancer related death today; lung cancer remains ... be diagnosed with prostate cancer during his lifetime. Those at highest risk are ...
(Date:6/24/2017)... ... 2017 , ... The weather is heating up and the days are getting ... be aware that the summer months provide more than warmer temperatures that are perfect ... be negatively affected from direct exposure to the sun. When it comes to the ...
(Date:6/23/2017)... ... ... By scoring 100% for fiscal management and accountability, the Arthritis National Research ... Charity Navigator, validating ANRF's work as a top charity in America. , This achievement ... earns ANRF a spot on their “ 10 Charities Worth Watching ” list as ...
(Date:6/23/2017)... ... 2017 , ... Dr. Ran Y. Rubinstein , a ... offering three new minimally invasive procedures to patients who want a younger and ... Rubinstein is excited to bring microneedling, microneedling facials, and platelet rich plasma (PRP) ...
(Date:6/23/2017)... ... June 23, 2017 , ... The Aesthetic Channel has recently highlighted Dr. ... come up with a proprietary technique that he calls the AuraLyft Facelift. ... For all ages, patients can expect to look refreshed, rejuvenated, and revitalized. , ...
Breaking Medicine News(10 mins):
(Date:6/14/2017)... -- ivWatch LLC, a medical device company focused on improving ... pleased to announce it was the Bronze Winner last ... Equipment at the 2017 Medical Design Excellence Awards (MDEAs), ... award was presented by Medical Device and Diagnostics Industry ... New York during MD&M East, the ...
(Date:6/13/2017)... 13, 2017 Zimmer Biomet Holdings, Inc. (NYSE and ... that the U.S. Food and Drug Administration (FDA) has notified ... relating to its Zhejiang, China manufacturing ... "The successful clearance of the Warning Letter related to ... is a measure of the progress we have made in ...
(Date:6/10/2017)... , June 9, 2017  Shane K. Burchfield, DPM, is recognized ... excellence as a Podiatrist in Alabama . ... Family First Foot Care. He brings over 20 years of experience, ... management and healthcare, to his role. ... Care, PC is pleased to welcome you to his ...
Breaking Medicine Technology: