Navigation Links
Adult Stem Cells Help Those With Immune Disorders, Heart Disease
Date:2/26/2008

Analysis of studies finds modest benefit with both conditions

TUESDAY, Feb. 26 (HealthDay News) -- Treatment with adult stem cells harvested from blood or bone marrow may benefit some patients with certain kinds of cardiovascular disorders and autoimmune diseases, a new U.S. analysis shows.

There are two types of stem cells, according to background information in the study. Embryonic stem cells are harvested from embryos four to five days after fertilization. Adult stem cells are located in tissues throughout the body and provide a reservoir for replacement of damaged or aging cells.

While stem cell therapy shows great promise, "clinical application has lagged due to ethical concerns [over embryonic stem cells] or difficulties harvesting or safely and efficiently expanding sufficient quantities," the review authors noted. "In contrast, clinical indications for blood-derived [from peripheral or umbilical cord blood] and bone marrow-derived stem cells, which can be easily and safely harvested, are rapidly increasing."

Dr. Richard K. Burt, of the Northwestern University Feinberg School of Medicine, and colleagues examined hundreds of studies of blood- or bone-marrow derived stem cells that were conducted between January 1997 and December 2007 -- 323 assessed feasibility and toxicity, and 69 looked at patient outcomes.

The review found that in 26 studies involving a total of 854 patients with autoimmune diseases there was a treatment-related death rate of: less than 1 percent (two of 220 patients) for nonmyeloablative (not causing bone marrow suppression); less than 2 percent (three of 197 patients) for dose-reduced myeloablative; and 13 percent (13 of 100 patients) for intense myeloablative regimens -- those including total body irradiation or high-dose busulfan, a drug used to treat some forms of chronic leukemia.

"While all trials performed during the inflammatory stage of autoimmune disease suggested that the transplantation of hematopoietic [formation of blood or blood cells] stem cells [HSCs] may have a potent disease-remitting effect, remission duration remains unclear, and no randomized trials have been published," the review authors wrote.

In 17 studies of 1,002 heart attack patients, 16 studies of 493 patients with chronic coronary artery disease, and three meta-analyses, there was evidence suggesting that adult stem cell transplantation may help lead to modest improvements in cardiac function among people with coronary artery disease.

More clinical trials are needed to determine the most appropriate stem cell type, dose, method, timing of delivery -- as well as adverse effects -- to treat cardiovascular and immune diseases and other disorders, the review authors concluded.

The study is published in the Feb. 27 issue of the Journal of the American Medical Association.

More information

The U.S. National Institutes of Health has more about stem cells.



-- Robert Preidt



SOURCE: Journal of the American Medical Association, news release, Feb. 26, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. A rare diagnosis in the operation room: Kidney atrophy due to duplicated colon in an adult
2. Cognitive Impairment Declining in Older Adults
3. CME LLC Offers Education to Help Medical Professionals Better Recognize Adult ADHD
4. Hand-held computers prod older adults to exercise more, Stanford study shows
5. JDRF partners with Plureon to explore generating insulin-producing cells from adult stem cells
6. Modified Atkins diet can cut epileptic seizures in adults
7. Anti-Inflammatory Drug Improves Glycemia, Lowers Inflammation in Obese, Young Adults
8. Teens, Young Adults Missing Out on Latest Cancer Advances
9. Turning on adult stem cells may help repair bone
10. Adult stem cell application effective in treatment of peripheric vascular disease
11. Governor Rendell Offers Coverage to 29,000 on AdultBasic Waiting List; Unveils New Policy to Improve Quality of Care for the Low-Income and Pennsylvanians With Disabilities
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Adult Stem Cells Help Those With Immune Disorders, Heart Disease
(Date:8/22/2017)... (PRWEB) , ... August 22, 2017 , ... “Wilderness Voices”: ... of world travel. “Wilderness Voices” is the creation of published author, Martha McKown, ... Martha McKown was inspired as a very young child when her older sisters studied ...
(Date:8/22/2017)... , ... August 22, 2017 , ... ... Stewart is the Founder and Managing Member for t4 Leadership Development & Consulting. ... critical to his definition of “success”: physician leadership development, servant leadership, data driven ...
(Date:8/21/2017)... (PRWEB) , ... August 22, 2017 , ... PracticeMatch, a ... to help healthcare employers connect with physicians and advanced practitioners like nurse practitioners ... career fairs in August through November of this year. The online career fairs ...
(Date:8/21/2017)... , ... August 21, 2017 , ... FCPX LUT Monochromatic ... Editors can quickly and easily add washed color grades to footage. A LUT is ... changes every pixel’s color to the corresponding color indicated by the table. This pack ...
(Date:8/21/2017)... ... August 21, 2017 , ... Duncan Insurance Agency ... the people of Michigan. The new initiative fundraises for the Kalamazoo Humane Society ... forefront of animal protection and welfare by addressing the root causes of pet ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... 7, 2017 Zimmer Biomet Holdings, Inc. (NYSE and ... that its Board of Directors has approved the payment of ... of 2017. The cash ... about October 27, 2017 to stockholders of record as of ... of dividends are subject to approval of the Board of ...
(Date:8/4/2017)... The search for test results that can ... has long been the goal of healthcare providers and ... the largest meeting of lab professionals and IVD firms ... firm Kalorama Information.  The firm said scores of companies ... supplies and software were at the American Association for ...
(Date:8/2/2017)... BENTON, Ky. , Aug. 2, 2017   Marshall County Hospital ... services (ES) team to proactively reduce the risk of hospital-acquired infections (HAIs). The new addition, ... that uses UVC light energy to kill deadly pathogens such as C. diff , ... Tru-D SmartUVC ... Tru-D in action in a patient ...
Breaking Medicine Technology: