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Adult Sickle Cell Drug May Benefit Kids, Too
Date:12/12/2011

s the paradigm from chronic palliation to an attempt to give the medication that now has a demonstrated track record of efficacy before damage is done."

A second study, also to be presented Sunday at the meeting, looked at the potential for a side effect from hydroxyurea called genotoxicity. A drug with genotoxic effects has the potential to damage DNA. Some laboratory tests had suggested that this could be possible with hydroxyurea.

Researchers from the Baylor College of Medicine in Houston and elsewhere looked for evidence of DNA damage in the babies and toddlers enrolled in the Baby Hug study. They found no significant differences in signs indicating DNA damage between kids on the drug and kids on a placebo, suggesting that any potential for genotoxicity is low.

Research presented at medical meetings should be considered preliminary until published in a peer-reviewed journal.

More information

To learn more about hydroxyurea, visit the U.S. National Library of Medicine.

SOURCES: Zora Rogers, M.D., professor of pediatrics, University of Texas Southwestern Medical Center at Dallas, and clinical director, bone marrow failure and general hematology program, Children's Medical Center in Dallas; Lakshmanan Krishnamurti, M.D., director, hematology and hemoglobinopathy, Children's Hospital of Pittsburgh, and associate professor of pediatrics, University of Pittsburgh School of Medicine; Dec. 11, 2011, presentations, American Society of Hematology annual meeting, San Diego


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