Patient selection was restricted to people with mild to moderate dementia, measuring 14 to 26 on the mini mental status examination scale and one to two on the clinical dementia rating scale.
In the healthy controls, previous ADHD symptoms were assessed using information from the subjects and direct informants. In patients with cognitive impairment, the assessment was based on symptoms described by direct informants who had known the patient for at least 10 years and had information obtained from a close relative who knew the patient in childhood.
Two neurologists, who were unaware of the objectives of the study, were independently asked to assess all the patients for adult ADHD using:
This produced agreement levels of 98 per cent in the DLB group, 96 per cent in the Alzheimer's group and 97.5 per cent in the control group.
A third neurologist provided their judgement in the small number of cases where the first two disagreed and a diagnosis of ADHD was recorded if two out of the three neurologists agreed. The results were then checked by a fourth neurologist fully informed about the objectives of the study.
These results provided an overall diagnosis of previous adult ADHD for the two dementia groups and the control. They also showed that impulsivity and hyperactivity, which are major symptoms of ADHD, were significantly higher in the DLB group than the Alzheimer's group and the control group (measuring 14.7, 5.9 and 6.4 respectively on the Wender Utah
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