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Adrenaline Therapy for Cardiac Arrest Linked to Worse Outcomes
Date:3/20/2012

By Randy Dotinga
HealthDay Reporter

TUESDAY, March 20 (HealthDay News) -- The decades-old practice of treating cardiac arrest patients with epinephrine -- adrenaline -- might do more harm than good in the long run, suggests a new analysis of hundreds of thousands of cases.

Japanese researchers found that cardiac arrest patients given epinephrine were more likely to survive one month, compared with those who didn't get the treatment. But when the investigators adjusted their figures statistically so they wouldn't be thrown off by various factors, the patients who got epinephrine actually became less likely to survive a month.

And among those given epinephrine who did survive, only one-quarter of them were in good shape neurologically a month later, the study authors noted.

On the other hand, the patients who received the drug were more likely to have their pulses restored before they got to the hospital, according to the report published in the March 21 issue of the Journal of the American Medical Association.

Dr. Clifton Callaway, an executive vice chair of emergency medicine at the University of Pittsburgh who wrote an accompanying journal editorial, said the new findings raise questions about the routine use of the drug.

"We need to figure out why those patients aren't doing well," Callaway said. "It improves that likelihood that we'll get the heartbeat back, but it looks like we're paying a price."

Cardiac arrest occurs when the heart fails to beat properly. It's not the same as a heart attack, although a heart attack can lead to cardiac arrest.

Physicians and paramedics often use epinephrine in conjunction with cardioversion -- the shocking of the heart with electricity -- to restore the heart to its normal rhythm in patients with cardiac arrest.

Although the drug was once given directly to the heart through a long needle, that doesn't happen anymore, Callaway said. Th
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