Navigation Links
Adolescent body mass index can predict young adulthood diabetes and heart disease
Date:4/6/2011

BEER-SHEVA, ISRAEL - April 7, 2011 A large cohort study following 37,000 teenagers for 17 years found that an elevated, yet normal range Body Mass Index (BMI) constitutes a substantial risk factor for obesity-related disorders in young adults (age 30-40).

The study showed that elevated BMI in adolescence has distinctive relationships with type 2 diabetes and coronary heart disease in young adulthood.

Researchers showed that diabetes is influenced mainly by recent BMI and weight gain. However, for coronary heart disease, both elevated BMI in adolescence and recent BMI are independent risk factors. The natural progression of coronary heart disease is probably the consequence of gradually increasing atherosclerosis during adolescence and early adulthood. It is important to note that these results were derived with BMI from well within the range defined as normal.

The study, published in the New England Journal of Medicine, assessed the occurrence of both diseases in young adulthood, an age group that has been rarely studied, but has experienced an increase in the incidence of these diseases in recent decades. It may help redefine what constitutes a "normal" or "healthy" BMI in adolescence and to highlight the role of elevated BMI at different ages in the diagnosis of different diseases.

The joint research team was led by Dr. Amir Tirosh (Sheba Tel-Hashomer Hospital's Talpiot program and Brigham and Women's Hospital and Harvard Medical School) and Profs. Iris Shai and Assaf Rudich from Ben-Gurion University of the Negev. Additional researchers from the Israel Defense Forces (IDF) Medical Corps and Tel Hashomer Hospital were also involved. The team followed IDF career personnel beginning at age 17.

The IDF recorded BMI of personnel (BMI, the weight in kilograms divided by the squared height in meters) at baseline and again every few years. During a mean follow-up period of 17 years, the average BMI of the participants rose at a rate of 0.2 to 0.3 units per year, reaching an average weight gain of approximately 15 Kg. (~30 lbs) between ages 17 and 30. The researchers were able to control for multiple risk factors for both diseases, including age, fasting blood glucose, blood lipids, blood pressure, smoking, exercise habits and family history.

The researchers found that it was possible to predict the increased risk for developing both diabetes and coronary heart disease even if the BMI was within the normal range (<25 Kg/m2) . A BMI of 25 or more is considered overweight while 30 BMI or higher is considered obese.

According to the study, every rise in one unit of BMI was associated with ~10 percent increased risk for type 2 diabetes in early adulthood, and a 12 percent increase in the risk for heart disease. Remarkably, this elevated risk was significant at a BMI at age 17 of 23.4 Kg/m2 or higher for diabetes and 20.9 Kg/m2 or higher for heart disease.

For diabetes, BMI at age 17 predicted the risk mainly since it associated with BMI later in life. However, for heart disease, both BMI at adolescence, as well as BMI at adulthood independently of each other predicted the risk of the disease. During the 17 year study period, 1,173 new cases of diabetes and 327 new cases of heart disease were diagnosed.

According to Dr. Tirosh, "Our results suggest that the obesity problem in children and teens is likely just the tip of an iceberg for increased risk for the occurrence of type 2 diabetes and heart disease in your 30s and 40s. While this is an observational study, it does suggest that an adolescent with a relatively high BMI, who grows up to become a lean adult, practically eliminated the added risk of developing diabetes attributed to his BMI at adolescence.

"Conversely, the risk of that person for heart disease will remain elevated compared to the lean teen who became a lean adult, though still will be lower than that of the heavier teen who became an obese adult. Therefore, for effective prevention of early occurrence of heart disease in adulthood, very early intervention to promote healthy lifestyle habits seems essential, even during childhood."

According to Prof. Iris Shai of BGU's Department of Epidemiology, Faculty of Health Sciences (FOHS), "Heart disease appears to have a longer 'memory' for BMI than diabetes, so the history of a person's BMI should be part of medical risk assessment. We have options, not necessarily pharmacological, to offer patients to decrease their risk for heart disease."

BGU recently published a series of intervention studies that showed that nutritional habits modification cannot only halt, but even reverse the progression of atherosclerosis, the underlying process of heart disease.

"Previous studies did not unequivocally confirm the association between pre-adulthood BMI and diseases in early adulthood, although extreme obese children are indeed more likely to become obese adults who are at elevated risk of diabetes and heart disease," explains Prof. Assaf Rudich, a researcher in the BGU FOHS and the National Institute for Biotechnology in the Negev.

"This study is significant because it demonstrates that the association exists well within the currently considered normal values for BMI, having distinct effect on two diseases occurring specifically in early adulthood an age group that is frequently neglected," says Rudich.


'/>"/>

Contact: Andrew Lavin
alc@alavin.com
516-353-2505
American Associates, Ben-Gurion University of the Negev
Source:Eurekalert

Related medicine news :

1. Sleep problems and sleepiness increase the risk of motor vehicle accidents in adolescents
2. Hey, thats my shirt! Sibling conflict harms trust and communication between adolescent siblings
3. Adolescent drinking adds to risk of breast disease, breast cancer
4. New Research Demonstrates Gains in Emergent Reading Skills for Adolescents with Autism and Intellectual Disabilities
5. Playing a video game before bedtime has only a mild effect on adolescent sleep
6. Less sleep may add up to more pounds in adolescents
7. Physical activity reduces the effect of the obesity gene in adolescents
8. Adolescent brains biologically wired to engage in risky behavior, study finds
9. Study Seeks Effective Treatment for Adolescent Low Back Pain
10. Adolescent cyberbullies and their victims may have physical, mental health problems
11. New study challenges stereotypes of adolescent sex offenders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2017)... ... July 21, 2017 , ... ... selected to renovate and improve the Ramsey County Medical Examiners Facility located in ... Hospital, the $2.5 million project is scheduled to start in late 2017/early 2018. ...
(Date:7/21/2017)... ... 21, 2017 , ... Bernard R. Bach, Jr., MD, orthopaedic surgeon at Rush ... Society of Sports Medicine (AOSSM) , received the 2017 Robert E. Leach Sports Medicine ... Canada. This prestigious award is given annually to honor those who have made a ...
(Date:7/21/2017)... (PRWEB) , ... July 21, 2017 , ... ... 4th-year medical students improve their chances of acceptance to a residency in a ... who have earned degrees outside the U.S. , According to data released by ...
(Date:7/21/2017)... TORONTO, ONTARIO, CANADA (PRWEB) , ... July 21, ... ... with over 80% follow-up at 10 years, researchers from the Multicenter Orthopaedics Outcome ... knee-related quality of life a decade after surgery, though activity levels decline over ...
(Date:7/20/2017)... (PRWEB) , ... July 20, 2017 , ... ChenMed ... MD, has joined JenCare Senior Medical Center as Richmond Chief Medical Officer. ... School of Medicine, and Associate Chief Medical Officer of Ambulatory Services for the UVA ...
Breaking Medicine News(10 mins):
(Date:7/13/2017)... 2017  New York City-based market research firm Kalorama Information ... aware of.  From new products to new costs, to the ... recently completed study, Potential Pipeline Disruptors . ... 1.  Age-Driven Growth - True Impact Moment Arriving ... the impact the growing population and, to a more extreme ...
(Date:7/11/2017)... , July 11, 2017  The global market ... revenues of approximately $394.1 million in 2016.  Although in ... of solid growth, in particular as a result of ... practice, and the recent introduction of a significant number ... for less-invasive testing of tumor biomarkers to guide treatment ...
(Date:7/10/2017)... Md. , July 10, 2017 The ... non-animal test methods, is the recipient of a VITROCELL® ... the PETA International Science Consortium. The device, which is ... used to expose human lung cells to airborne test ... IIVS will use the VITROCELL® system for testing combustible ...
Breaking Medicine Technology: