Navigation Links
Adjuvant chemotherapy increases markers of molecular aging in the blood of BC survivors
Date:3/28/2014

Adjuvant chemotherapy for breast cancer is "gerontogenic", accelerating the pace of physiologic aging, according to a new study published March 28 in the Journal of the National Cancer Institute.

Loss of organ function, characterized by an increase in cellular senescence, is one physiological part of aging. Studies have identified leukocyte telomere length, expression of senescence-associated cytokines including interleukin-6, and expression of p16INK4aand ARF in peripheral blood T lymphocytes (PBTLs) as markers of cellular senescence. The authors previously showed p16INK4a is a marker of accelerated molecular age in PBTLs associated with smoking, physical inactivity, and chronic human immunodeficiency virus infection. To date, the long term effect of cytotoxic chemotherapy given with curative intent on molecular aging has not been reported.

Hanna K. Sanoff, M.D., Norman E. Sharpless, M.D., and Hyman B. Muss, M.D., and their colleagues prospectively collected blood and clinical data from 33 women with stage I-III breast cancer before, immediately after, 3 months after, and 12 months after anthracycline-based chemotherapy. Blood was analyzed for markers of cellular senescence. They observed increased expression of the senescence markers p16INK4a and ARF in PBLTs immediately after chemotherapy, and which remained elevated for at least a year after treatment. In an independent cohort of 176 breast cancer survivors, prior chemotherapy was associated with a persistent increase in p16INK4a at an average of 3.4y after treatment. These results suggest the age-promoting effects of chemotherapy last for several years after treatment, and may be permanent.

The authors conclude, "We have shown that cytotoxic chemotherapy potently induces the expression of markers of cellular senescence in the hematologic compartment in vivo, comparable with the effects of 10 to 15 years of chronologic aging in independent cohorts of healthy donors." Fur
'/>"/>

Contact: Zachary Rathner
Zachary.Rathner@oup.com
919-677-2697
Oxford University Press USA
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Breast cancer patients who lack RB gene respond better to neoadjuvant chemotherapy
2. Prospective study finds many children with retinoblastoma can safely forego adjuvant chemotherapy
3. EORTC study identifies patients with anaplastic oligodendroglioma that benefit from adjuvant PCV
4. Crop Protection Chemicals Market (Herbicides, Fungicides, Insecticides, Bio-Pesticides and Adjuvants) Worth $66,527.8 Million by 2018 - New Report by MarketsandMarkets
5. Adjuvants Market (Type, Utility, Application) Worth $2,963.2 Million by 2018 - New Report by MarketsandMarkets
6. Adjuvants Market (Surfactants, Oils, Ammonium Fertilizer) Worth $2,963.2 Million by 2018 - New Report by MarketsandMarkets
7. Safety and immunogenicity of 2 doses of the HPV-16/18 AS04 adjuvanted vaccine Cervarix
8. Chemotherapy proves life-saving for some leukemia patients who fail induction therapy
9. Adding drug to standard chemotherapy provides no survival benefit for older lung cancer patients
10. Genetic predictor of breast cancer response to chemotherapy
11. Chemotherapys effect on overall survival seems to increase based on tumor size
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... July 23, 2014 PartnerTech Inc. ... in Lawrenceville, Georgia, welcomed Andreas von Uexkull to their ... of the U.S. von Uexkull, a top trade official ... tour of the U.S. to bring awareness and insight ... and Investment Partnership (TTIP). , As an expert ...
(Date:7/23/2014)... Picnic Lunches, Residents of The Clare can now enjoy the ... still dining on the fabulous cuisine of Chef Hagop Hagopian. ... to the beach or museum and we love to make ... said Brian Hughes, director of dining services for The Clare. ... , Hagopian, the executive chef of The Clare is trained ...
(Date:7/22/2014)... 22, 2014 Men and women who ... a portion of their disposable income each year on ... promoting its best anti aging products guide to help ... products guide is now released and accessible from any ... Known retailers were selected and inserted into the guide ...
(Date:7/22/2014)... Recently, iFitDress.com, a popular supplier of wedding dresses and special ... white party dresses to its product category. Additionally, ... available on its website. As a special offer, all customers ... get a discounted rate, up to 54% off. , A ... so its marketing specialist believes the new white party dresses ...
(Date:7/22/2014)... 23, 2014 Marietta, Georgia and surrounding areas ... In an efforts to lower population of needy pets; ... the Tigg Neuter Project have joined forces. Local businesses ... All proceeds will be presented to the Tigg Neuter Project. ... clinic family are excited to attend and host the event. ...
Breaking Medicine News(10 mins):Health News:Swedish Official Tours PartnerTech’s U.S. Facility 2Health News:Swedish Official Tours PartnerTech’s U.S. Facility 3Health News:Chicago’s The Clare Retirement Community Announces New Summertime Culinary Programs 2Health News:Best Anti Aging Products Guide Launched for Natural Product Buyers Online at News Portal 2Health News:Elegant White Party Dresses Now Provided by Distinguished Company iFitDress.com 2Health News:Marietta Vet Clinic Hosts 2014 Dog Days of Summer Pet Rescue Event 2
... orders to protect their skin from the sun. In the ... Jung and their research group have found skin cancer rates ... off for women. This comes at a time when American ... Metelitsa and Jung analyzed data collected over a 20-year period ...
... without symptoms, screening mammography may be inappropriate, researchers say , ... the age of 40 result in many return visits for ... new study finds. , Almost 30 percent of U.S. ... mammograms, although they,re not generally recommended until age 40. ...
... Rise-N-Shine, LLC,s "Go Away Gray” ... Sparta, NJ (Vocus) May 3, ... get rid of it. Women and men routinely spend a fortune on coloring those grays, but now ... , , , ,Beth Skelly of Ft. Lauderdale, Florida was going gray and tried all kinds of ...
... consider age when evaluating risks, study suggests , MONDAY, May ... pelvic CT scans are twice as high for younger patients ... risks associated with ionizing radiation is complex," study author Dr. ... in a news release. "Many variables such as patient size, ...
... While timely care can reduce stress among breast cancer ... compromise other factors important to care, such as safety, effectiveness, ... the April issue of the Journal of the American ... cancer diagnosis and one in eight women will receive ...
... A simple salad spinner will save lives this summer, if ... The spinner has been turned, so to speak, into ... use to separate blood without electricity. Rice sophomore ... Centrifuge abroad for nearly two months this summer as part ...
Cached Medicine News:Health News:New Pill Promises to Stop Gray Hair 2Health News:New Pill Promises to Stop Gray Hair 3Health News:Radiation Risks Nearly Double for Younger CT Scan Patients 2Health News:Study evaluates importance of timeliness of care in breast cancer diagnosis and treatment 2Health News:Study evaluates importance of timeliness of care in breast cancer diagnosis and treatment 3Health News:Revolution with a salad spinner 2
(Date:7/22/2014)... 2014 Research and Markets has ... by Equipment, by Reagent, by Application - Global Forecast ... http://photos.prnewswire.com/prnh/20130307/600769 Biopharmaceuticals are ... one of the most important and widely used techniques ... segment of the cell culture market in 2013. Growth ...
(Date:7/22/2014)... 22, 2014 Legislation backed by the ... Local Pharmacies Act of 2014") championing so-called "any ... undermine the availability of lower cost preferred pharmacy ... over the next 10 years, according to new ... Pharmaceutical Care Management Association (PCMA). The ...
(Date:7/22/2014)... 22, 2014 According to ... Spectroscopy Market (Technology Types - Near infrared (NIR) spectroscopy, Raman ... Industry Analysis, Size, Share, Growth, Trends and Forecast, 2013 - ... 2012 and is expected to grow at a CAGR of ... America was the largest contributor to global process ...
Breaking Medicine Technology:Global Cell Culture (Bioreactor, Incubator, Centrifuge) Market - Forecast to 2018 2Global Cell Culture (Bioreactor, Incubator, Centrifuge) Market - Forecast to 2018 3New Study: H.R. 4577 to Cost $21 Billion over 10 Years 2New Study: H.R. 4577 to Cost $21 Billion over 10 Years 3Process Spectroscopy Market Expected to Reach USD 1,179.6 Million in 2019: Transparency Market Research 2Process Spectroscopy Market Expected to Reach USD 1,179.6 Million in 2019: Transparency Market Research 3Process Spectroscopy Market Expected to Reach USD 1,179.6 Million in 2019: Transparency Market Research 4
... 2012 Accuray Incorporated (Nasdaq: ARAY ), the ... scheduled to present at the Needham Growth Conference in New ... EST/5:40 a.m. PST.  A live webcast of ... page of the Company,s website at http://www.accuray.com .  The ...
... today announced that the U. S. District Court in ... Synvisc-One ® (hylan G-F 20) competitor ... a restricted launch of Seikagaku,s product prior to a ... selling their product below the current average sales price ...
Cached Medicine Technology:Sanofi Announces Court Ruling Granting Preliminary Injunction Against Synvisc-One® Competitor Product 2
... the typical patient, right for the not-so-typical ... you have the ability to address the ... least expect themeven after implant. St. Jude ... to be prepared in almost any situation, ...
... The R4Mplus offers global companies a ... meet RFID compliance initiatives. With die-cast ... variety of connectivity options, and complex ... a super value. Plus, the fully ...
... combines enhanced memory, processing capacity, ... reliable all-metal construction. Proven platform ... print speed make it the ... value reliability, productivity, consistent print ...
... companies a cost-effective and dependable performer ... With die-cast metal construction, centralized printer/encoder ... and complex multi-language font support, the ... the fully integrated RFID reader/encoder supports ...
Medicine Products: