Navigation Links
Adjuvant chemotherapy increases markers of molecular aging in the blood of BC survivors
Date:3/28/2014

Adjuvant chemotherapy for breast cancer is "gerontogenic", accelerating the pace of physiologic aging, according to a new study published March 28 in the Journal of the National Cancer Institute.

Loss of organ function, characterized by an increase in cellular senescence, is one physiological part of aging. Studies have identified leukocyte telomere length, expression of senescence-associated cytokines including interleukin-6, and expression of p16INK4aand ARF in peripheral blood T lymphocytes (PBTLs) as markers of cellular senescence. The authors previously showed p16INK4a is a marker of accelerated molecular age in PBTLs associated with smoking, physical inactivity, and chronic human immunodeficiency virus infection. To date, the long term effect of cytotoxic chemotherapy given with curative intent on molecular aging has not been reported.

Hanna K. Sanoff, M.D., Norman E. Sharpless, M.D., and Hyman B. Muss, M.D., and their colleagues prospectively collected blood and clinical data from 33 women with stage I-III breast cancer before, immediately after, 3 months after, and 12 months after anthracycline-based chemotherapy. Blood was analyzed for markers of cellular senescence. They observed increased expression of the senescence markers p16INK4a and ARF in PBLTs immediately after chemotherapy, and which remained elevated for at least a year after treatment. In an independent cohort of 176 breast cancer survivors, prior chemotherapy was associated with a persistent increase in p16INK4a at an average of 3.4y after treatment. These results suggest the age-promoting effects of chemotherapy last for several years after treatment, and may be permanent.

The authors conclude, "We have shown that cytotoxic chemotherapy potently induces the expression of markers of cellular senescence in the hematologic compartment in vivo, comparable with the effects of 10 to 15 years of chronologic aging in independent cohorts of healthy donors." Further studies are underway.


'/>"/>

Contact: Zachary Rathner
Zachary.Rathner@oup.com
919-677-2697
Oxford University Press USA
Source:Eurekalert

Related medicine news :

1. Breast cancer patients who lack RB gene respond better to neoadjuvant chemotherapy
2. Prospective study finds many children with retinoblastoma can safely forego adjuvant chemotherapy
3. EORTC study identifies patients with anaplastic oligodendroglioma that benefit from adjuvant PCV
4. Crop Protection Chemicals Market (Herbicides, Fungicides, Insecticides, Bio-Pesticides and Adjuvants) Worth $66,527.8 Million by 2018 - New Report by MarketsandMarkets
5. Adjuvants Market (Type, Utility, Application) Worth $2,963.2 Million by 2018 - New Report by MarketsandMarkets
6. Adjuvants Market (Surfactants, Oils, Ammonium Fertilizer) Worth $2,963.2 Million by 2018 - New Report by MarketsandMarkets
7. Safety and immunogenicity of 2 doses of the HPV-16/18 AS04 adjuvanted vaccine Cervarix
8. Chemotherapy proves life-saving for some leukemia patients who fail induction therapy
9. Adding drug to standard chemotherapy provides no survival benefit for older lung cancer patients
10. Genetic predictor of breast cancer response to chemotherapy
11. Chemotherapys effect on overall survival seems to increase based on tumor size
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... ... ... Cheryl Bowker of Bowker Insurance Group has been presented with one of ... McKenna ran one of Allstate’s most successful agencies for 48 years, but it was ... The award named for him is not given every year, but only when an ...
(Date:5/25/2016)... (PRWEB) , ... May 25, 2016 , ... ... solutions to industries ranging from medical and pharmaceutical, to food and HVAC facilities. ... well as on-site training. , For medical applications, Afrimesure offers a variety ...
(Date:5/25/2016)... ... May 25, 2016 , ... Conrad Siegel Actuaries, delivering comprehensive ... Prescription Drug survey , an employee benefits survey measuring how Central ... December 2015, indicates that employers are turning to consumer directed health care and ...
(Date:5/25/2016)... ... ... than fifty years, we've suffered whiplash as each new scientific study seemed to contradict the ... advice – advice that was supposed to keep us healthy and slim. And what happened? ... considered to be overweight and more than 1 in 3 adults are considered to be ...
(Date:5/25/2016)... ... May 25, 2016 , ... BeniComp ... a significant spike in their clients' employee participation for their wellness initiatives. ... by implementing a high-deductible health plan with outcome-based deductible incentives. As a result, ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... , May 24, 2016 ... doble terapia del mundo, introduce catéteres para la ... OrbusNeich, una compañía global especializada en el ... ha expandido su cartera incluyendo productos para tratar ... y Scoreflex™ PTA son los dispositivos de primera ...
(Date:5/23/2016)... May 23, 2016 According ... Equipment Market by Product (Wheelchair, Scooters, Medical Beds, ... Care, Critical Care, Wound), Accessories (Lifting, Transfer) & ... 2021", published by MarketsandMarkets, the patient handling equipment ... by 2021 at a CAGR of 10.5% during ...
(Date:5/23/2016)... 2016 Clarifying Vision - Prospects ... and Vision Care What can be expected ... to grow at the fastest rates? This visiongain ... data, trends, opportunities and prospects. ,Our ... the most lucrative areas in the industry and the ...
Breaking Medicine Technology: