Navigation Links
Adjunctive rufinamide reduces refractory partial-onset seizures
Date:9/30/2010

Researchers from the Arkansas Epilepsy Program found treatment with rufinamide results in a significant reduction in seizure frequency compared with placebo, for patients with uncontrolled partial-onset seizures (POS). Details of this study are now available online in Epilepsia, a journal published by Wiley-Blackwell on behalf of the International League Against Epilepsy.

Epilepsy affects up to 2% of the worldwide population according to the Centers for Disease Control and Prevention. More than half of these patients experience POS, or focal seizures, which are initiated in one part of the brain. Despite an expanding number of antiepileptic drugs (AEDs) available to treat partial-onset epilepsy, about one-third of epilepsy patients remain resistant to available treatments and many more experience intolerable side effects, driving the search for therapeutic alternatives. The current study evaluated rufinamide, an AED with a novel triazole-derivative structure, to confirm its efficacy and safety at a dose of 1,600 mg twice daily as adjunctive treatment for refractory POS.

Eligible patients were male or female, aged 12-80 years, with POS with or without secondarily generalized seizures. Patients' seizures were inadequately controlled on stable doses of up to three concomitantly administered AEDs, with no evidence of AED treatment noncompliance. All medication taken regularly by patients, including AEDs, remained unchanged for at least 1 month prior to study start and throughout the study. Patients were enrolled at 61 centers in the U.S. and at four centers in Canada between February 2006 and March 2009. In total, 357 patients were randomly assigned to receive rufinamide (n = 176) or placebo (n = 181) and entered the titration phase, and 139 and 156 patients, respectively, completed the study. This study comprised a 56-day baseline phase (BP), 12-day titration phase, and 84-day maintenance phase (MP).

The researchers found that
'/>"/>

Contact: Dawn Peters
healthnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

Page: 1 2

Related medicine news :

1. After traumatic event, early intervention reduces odds of PTSD in children by 73 percent
2. Nonstick coating of a protein found in semen reduces HIV infection
3. Smoked cannabis reduces chronic pain
4. Reminding health-care staff to remove catheters reduces infections by half
5. New drug reduces tumor size in women with advanced hereditary ovarian or breast cancer
6. Brain study shows that thinking about God reduces distress -- but only for believers
7. Teenage physical activity reduces risk of cognitive impairment in later life
8. Filtering donor blood reduces heart, lung complications
9. Lifestyle intervention reduces preschoolers body fat, improves fitness
10. Breast Milk Reduces Infections in Babies
11. Hopes Dashed That Vitamin D Reduces Cancer Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... Kansas City, MO (PRWEB) July 30, 2014 ... care practices have recently been awarded the Patient-Centered ... bestowed by the National Committee for Quality Assurance. ... has achieved NCQA Level I, Level 2, or ... doctors who participate in Patient-Centered Medical Home report ...
(Date:7/29/2014)... 2014 1Heart Caregiver Services’ advocacy ... focus on Brain Fitness Education brings great acceptance ... Fitness Program Director Tee Barr delivered an exceptional ... unit and the Assisted Living section of Aegis ... Director Christy Rozsa and Aegis Life Neighborhood Director ...
(Date:7/29/2014)... 2014 VogueQueen.com, a well-known online supplier, ... newest trends in garment fashion by providing graceful and ... selling an all-inclusive array of sexy dresses , ... a lot of customers take price into consideration. Worry ... makes the purchase more affordable for all clients. ...
(Date:7/29/2014)... 29, 2014 Daily Gossip indicates that ... all other disturbing symptoms that hemorrhoids commonly causes. The ... and natural medicine expert. , The author of ... the elimination of symptoms such as itching, burning, pain ... more about the H Miracle by visiting the official ...
(Date:7/29/2014)... (EA) a form of acupuncture where a ... acupuncture needles produces significant improvements in fatigue, ... weeks for early stage breast cancer patients experiencing ... inhibitors (AIs) to treat breast cancer. The results ... led by researchers at the Perelman School of ...
Breaking Medicine News(10 mins):Health News:Saint Luke’s Medical Group Awarded Patient-Centered Medical Home 2011 Level 3 Recognition 2Health News:1Heart Caregiver Services Conducts Brain Fitness Education and Brings Tee Barr to Aegis Ventura 2Health News:1Heart Caregiver Services Conducts Brain Fitness Education and Brings Tee Barr to Aegis Ventura 3Health News:1Heart Caregiver Services Conducts Brain Fitness Education and Brings Tee Barr to Aegis Ventura 4Health News:VogueQueen.com Now Provides Graceful And Sexy Lingerie Collection For August 2Health News:H Miracle Review Exposes Natural Method to Cure Hemorrhoids 2Health News:Acupuncture improves quality of life for breast cancer patients using aromatase inhibitors 2Health News:Acupuncture improves quality of life for breast cancer patients using aromatase inhibitors 3
... New research shows a link between use of two ... used either pesticide developed Parkinson,s disease approximately 2.5 times ... a collaborative effort conducted by researchers at the National ... of the National Institutes of Health, and the Parkinson,s ...
... Reinberg HealthDay Reporter , SUNDAY, Feb. 13 ... antioxidants called flavonoids, especially berries, may be protecting themselves ... In addition to berries, flavonoids are found in a ... fruits. These compounds have been touted as protective against ...
... 12 (HealthDay News) -- Winter couch potatoes who decide to ... injury if they don,t take the proper steps to safely ... an exercise program or new sport, you need to get ... fitness, advised Dr. Anders Cohen, chief of neurosurgery and spine ...
... HealthDay Reporter , FRIDAY, Feb. 11 (HealthDay ... regularly, their ability to think, to plan and even ... In addition, exercise was linked to increased activity in ... and self-control, according to brain imaging scans analyzed by ...
... 11 (HealthDay News) -- In addition to the ... one dermatologist cautions that players may be sharing ... "Outbreaks of ringworm, herpes and methicillin-resistant Staphylococcus aureus ... and professional level throughout the world," dermatologist Dr. ...
... the enzyme that gives fireflies their glow, enables researchers ... thereby track the progression of infectious diseases or cancerous ... shave their fur. Developed by researchers with the Lawrence ... California (UC) Berkeley, this new bioluminescent probe has already ...
Cached Medicine News:Health News:NIH study finds 2 pesticides associated with Parkinson's disease 2Health News:Berries May Offer Sweet Protection Against Parkinson's Disease 2Health News:Berries May Offer Sweet Protection Against Parkinson's Disease 3Health News:Get Into Shape Before Spring Activities, Doctor Advises 2Health News:Overweight Kids Who Exercise Improve Thinking, Math Skills: Study 2Health News:Overweight Kids Who Exercise Improve Thinking, Math Skills: Study 3Health News:Skin Infections Can Spread Easily Among Athletes 2Health News:Skin Infections Can Spread Easily Among Athletes 3Health News:Firefly glow: Berkeley Lab scientists develop a hydrogen peroxide probe based on firefly luciferin 2Health News:Firefly glow: Berkeley Lab scientists develop a hydrogen peroxide probe based on firefly luciferin 3
(Date:7/29/2014)... , July 29, 2014  Landauer, Inc. (NYSE: ... and environmental radiation measurement and monitoring, outsourced medical physics ... financial results for the fiscal third quarter 2014 after ... The Company will host a conference call ... a.m. Central Time (10 a.m. Eastern Time). Investors may ...
(Date:7/29/2014)... WASHINGTON , July 29, 2014 New ... in Medicare Part D by a projected $2.9 to ... by the actuarial firm Milliman released today by the ... Part D premiums could increase by as much as ... hepatitis C drugs, including Sovaldi and Olysio. ...
(Date:7/29/2014)... July 29, 2014 Numotion,s Board of Directors has ... will be the company,s new Chief Executive Officer. ... career at GE where he worked primarily for GE Healthcare ... to over $5 billion. His most recent position was as ... "I am thrilled to join Numotion," said Mike ...
Breaking Medicine Technology:Landauer, Inc. Sets Date and Time for Announcement of Fiscal Third Quarter 2014 Results 2New Milliman Study: Hepatitis C Drugs Could Increase Medicare Part D Spending by $2.9 to $5.8 Billion in 2015 2Numotion Names Mike Swinford CEO 2
... 3, 2011 Nonin Medical, Inc., the inventor of ... a leader in noninvasive physiological monitoring, announced the worldwide ... Pulse Oximeter for medical monitoring manufacturers. ... wired pulse oximeter will provide a new level of ...
... Optimer Pharmaceuticals, Inc. (NASDAQ: OPTR ) ... Senior Vice President of Research and Development, Cynthia Schwalm ... M.D., as Senior Vice President of Pharmacovigilance. These newly ... the Company prepares for the potential launch of its ...
Cached Medicine Technology:Nonin Medical Launches Low Power Xpod®, Model 3012LP, OEM Pulse Oximeter Globally 2Optimer Pharmaceuticals Expands Senior Management Team 2Optimer Pharmaceuticals Expands Senior Management Team 3Optimer Pharmaceuticals Expands Senior Management Team 4Optimer Pharmaceuticals Expands Senior Management Team 5
Molt periosteal elevator #9, 18.5 cm, 7-1/4"....
Periosteal elevator #9, 18 cm, 7"....
Full curve periosteal elevator - cervical - sharp, round tip, length 184 mm (7 1/4")....
... The Frontier Anterior Deformity System ... Kass, Moss Miami, and Isola ... thoracoscopic procedures to deliver unsurpassed versatility, ... the highest level of versatility for ...
Medicine Products: